Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
Bentham, James, Morris, David L, Cunninghame Graham, Deborah S, Pinder, Christopher L, Tombleson, Philip, Behrens, Timothy W, Martín, Javier, Fairfax, Benjamin P, Knight, Julian C, Chen, Lingyan, Replogle, Joseph, Syvänen, Ann-Christine, Rönnblom, Lars, Graham, Robert R, Wither, Joan E, Rioux, John D, Alarcón-Riquelme, Marta E, Vyse, Timothy J
Published in Nature genetics (01.12.2015)
Published in Nature genetics (01.12.2015)
Get full text
Journal Article
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
Odhams, Christopher A., Roberts, Amy L., Vester, Susan K., Duarte, Carolina S. T., Beales, Charlie T., Clarke, Alexander J., Lindinger, Sonja, Daffern, Samuel J., Zito, Antonino, Chen, Lingyan, Jones, Leonardo L., Boteva, Lora, Morris, David L., Small, Kerrin S., Fernando, Michelle M. A., Cunninghame Graham, Deborah S., Vyse, Timothy J.
Published in Nature communications (15.05.2019)
Published in Nature communications (15.05.2019)
Get full text
Journal Article
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
Morris, David L, Sheng, Yujun, Zhang, Yan, Wang, Yong-Fei, Zhu, Zhengwei, Tombleson, Philip, Chen, Lingyan, Cunninghame Graham, Deborah S, Bentham, James, Roberts, Amy L, Chen, Ruoyan, Zuo, Xianbo, Wang, Tingyou, Wen, Leilei, Yang, Chao, Liu, Lu, Yang, Lulu, Li, Feng, Huang, Yuanbo, Yin, Xianyong, Yang, Sen, Rönnblom, Lars, Fürnrohr, Barbara G, Voll, Reinhard E, Schett, Georg, Costedoat–Chalumeau, Nathalie, Gaffney, Patrick M, Lau, Yu Lung, Zhang, Xuejun, Yang, Wanling, Cui, Yong, Vyse, Timothy J
Published in Nature genetics (01.08.2016)
Published in Nature genetics (01.08.2016)
Get full text
Journal Article
COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection
Wang, Yuxuan, Guga, Suri, Wu, Kejia, Khaw, Zoe, Tzoumkas, Konstantinos, Tombleson, Phil, Comeau, Mary E, Langefeld, Carl D, Cunninghame Graham, Deborah S, Morris, David L, Vyse, Timothy J
Published in PLoS genetics (03.11.2022)
Published in PLoS genetics (03.11.2022)
Get full text
Journal Article
Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus
Vyse, Timothy J, Cunninghame Graham, Deborah S
Published in International journal of molecular sciences (09.11.2020)
Published in International journal of molecular sciences (09.11.2020)
Get full text
Journal Article
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus
Cunninghame Graham, Deborah S, Morris, David L, Bhangale, Tushar R, Criswell, Lindsey A, Syvänen, Ann-Christine, Rönnblom, Lars, Behrens, Timothy W, Graham, Robert R, Vyse, Timothy J
Published in PLoS genetics (01.10.2011)
Published in PLoS genetics (01.10.2011)
Get full text
Journal Article
The genetics of lupus: a functional perspective
Guerra, Sandra G, Vyse, Timothy J, Cunninghame Graham, Deborah S
Published in Arthritis research & therapy (01.01.2012)
Published in Arthritis research & therapy (01.01.2012)
Get full text
Journal Article
Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us
Karrar, Sarah, Cunninghame Graham, Deborah S
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2018)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2018)
Get full text
Journal Article
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation
Manjarrez-Orduño, Nataly, Marasco, Emiliano, Chung, Sharon A, Katz, Matthew S, Kiridly, Jenna F, Simpfendorfer, Kim R, Freudenberg, Jan, Ballard, David H, Nashi, Emil, Hopkins, Thomas J, Cunninghame Graham, Deborah S, Lee, Annette T, Coenen, Marieke J H, Franke, Barbara, Swinkels, Dorine W, Graham, Robert R, Kimberly, Robert P, Gaffney, Patrick M, Vyse, Timothy J, Behrens, Timothy W, Criswell, Lindsey A, Diamond, Betty, Gregersen, Peter K
Published in Nature genetics (01.11.2012)
Published in Nature genetics (01.11.2012)
Get full text
Journal Article
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Vyse, Timothy J, Graham, Deborah S Cunninghame, Graham, Robert R, Manku, Harinder, Wong, Andrew K, Whittaker, John C, Gaffney, Patrick M, Moser, Kathy L, Rioux, John D, Altshuler, David, Behrens, Timothy W
Published in Nature genetics (01.01.2008)
Published in Nature genetics (01.01.2008)
Get full text
Journal Article
Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity
Chen, Lingyan, Wang, Yong-Fei, Liu, Lu, Bielowka, Adrianna, Ahmed, Rahell, Zhang, Huoru, Tombleson, Phil, Roberts, Amy L, Odhams, Christopher A, Cunninghame Graham, Deborah S, Zhang, Xuejun, Yang, Wanling, Vyse, Timothy J, Morris, David L
Published in Human molecular genetics (27.06.2020)
Published in Human molecular genetics (27.06.2020)
Get full text
Journal Article
B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis
Cortini, Andrea, Ellinghaus, Ursula, Malik, Talat H, Cunninghame Graham, Deborah S, Botto, Marina, Vyse, Timothy James
Published in Annals of the rheumatic diseases (01.12.2017)
Published in Annals of the rheumatic diseases (01.12.2017)
Get full text
Journal Article
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
Günther, Claudia, Kind, Barbara, Reijns, Martin A M, Berndt, Nicole, Martinez-Bueno, Manuel, Wolf, Christine, Tüngler, Victoria, Chara, Osvaldo, Lee, Young Ae, Hübner, Norbert, Bicknell, Louise, Blum, Sophia, Krug, Claudia, Schmidt, Franziska, Kretschmer, Stefanie, Koss, Sarah, Astell, Katy R, Ramantani, Georgia, Bauerfeind, Anja, Morris, David L, Cunninghame Graham, Deborah S, Bubeck, Doryen, Leitch, Andrea, Ralston, Stuart H, Blackburn, Elizabeth A, Gahr, Manfred, Witte, Torsten, Vyse, Timothy J, Melchers, Inga, Mangold, Elisabeth, Nöthen, Markus M, Aringer, Martin, Kuhn, Annegret, Lüthke, Kirsten, Unger, Leonore, Bley, Annette, Lorenzi, Alice, Isaacs, John D, Alexopoulou, Dimitra, Conrad, Karsten, Dahl, Andreas, Roers, Axel, Alarcon-Riquelme, Marta E, Jackson, Andrew P, Lee-Kirsch, Min Ae
Published in The Journal of clinical investigation (01.01.2015)
Published in The Journal of clinical investigation (01.01.2015)
Get full text
Journal Article
Nucleolin acts as the receptor for C1QTNF4 and supports C1QTNF4-mediated innate immunity modulation
Vester, Susan K., Beavil, Rebecca L., Lynham, Steven, Beavil, Andrew J., Cunninghame Graham, Deborah S., McDonnell, James M., Vyse, Timothy J.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
Get full text
Journal Article
Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus
Odhams, Christopher A, Cortini, Andrea, Chen, Lingyan, Roberts, Amy L, Viñuela, Ana, Buil, Alfonso, Small, Kerrin S, Dermitzakis, Emmanouil T, Morris, David L, Vyse, Timothy J, Cunninghame Graham, Deborah S
Published in Human molecular genetics (01.03.2017)
Published in Human molecular genetics (01.03.2017)
Get full text
Journal Article
Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation
Graham, Deborah S. Cunninghame, Manku, Harinder, Wagner, Susanne, Reid, Julia, Timms, Kirsten, Gutin, Alexander, Lanchbury, Jerry S., Vyse, Tim J.
Published in Human molecular genetics (15.03.2007)
Published in Human molecular genetics (15.03.2007)
Get full text
Journal Article
Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus
Russell, Andrew I., Cunninghame Graham, Deborah S., Shepherd, Christopher, Roberton, Cheri A., Whittaker, John, Meeks, John, Powell, Richard J., Isenberg, David A., Walport, Mark J., Vyse, Timothy J.
Published in Human molecular genetics (01.01.2004)
Published in Human molecular genetics (01.01.2004)
Get full text
Journal Article