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Published in The FEBS journal (01.12.2021)
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Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses
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Modified Hypoxia-Inducible Factor Expression in CD8 + T Cells Increases Antitumor Efficacy
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A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
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Published in eLife (2024)
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Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha, Pedro P, Minogue, Eleanor, Krause, Lena C M, Hess, Rita M, Bargiela, David, Wadsworth, Brennan J, Barbieri, Laura, Brombach, Carolin, Foskolou, Iosifina P, Bogeski, Ivan, Velica, Pedro, Johnson, Randall S
Published in eLife (11.05.2023)
Published in eLife (11.05.2023)
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Lactate exposure shapes the metabolic and transcriptomic profile of CD8+ T cells
Barbieri, Laura, Veliça, Pedro, Gameiro, Paulo A, Cunha, Pedro P, Foskolou, Iosifina P, Rullman, Eric, Bargiela, David, Johnson, Randall S, Rundqvist, Helene
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
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Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation
Gojkovic, Milos, Cunha, Pedro P, Darmasaputra, Gabriella S, Barbieri, Laura, Rundqvist, Helene, Veliça, Pedro, Johnson, Randall S
Published in Frontiers in immunology (12.05.2021)
Published in Frontiers in immunology (12.05.2021)
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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou, Iosifina P., Cunha, Pedro P., Sánchez-López, Elena, Minogue, Eleanor A., Nicolet, Benoît P., Guislain, Aurélie, Jorgensen, Christian, Kostidis, Sarantos, Zandhuis, Nordin D., Barbieri, Laura, Bargiela, David, Nathanael, Demitris, Tyrakis, Petros A., Palazon, Asis, Giera, Martin, Wolkers, Monika C., Johnson, Randall S.
Published in Cell reports (Cambridge) (26.09.2023)
Published in Cell reports (Cambridge) (26.09.2023)
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A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth, Brennan J, Leiwe, Marina, Minogue, Eleanor A, Cunha, Pedro P, Engman, Viktor, Brombach, Carolin, Asvestis, Christos, Sah-Teli, Shiv K, Marklund, Emilia, Koivunen, Peppi, Ruas, Jorge L, Rundqvist, Helene, Lanner, Johanna T, Johnson, Randall S
Published in eLife (03.09.2024)
Published in eLife (03.09.2024)
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The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
Bargiela, David, Cunha, Pedro P, Veliça, Pedro, Krause, Lena C M, Brice, Madara, Barbieri, Laura, Gojkovic, Milos, Foskolou, Iosifina P, Rundqvist, Helene, Johnson, Randall S
Published in Frontiers in immunology (2024)
Published in Frontiers in immunology (2024)
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Infiltration of Tumors Is Regulated by T cell-Intrinsic Nitric Oxide Synthesis
Cunha, Pedro P, Bargiela, David, Minogue, Eleanor, Krause, Lena C M, Barbieri, Laura, Brombach, Carolin, Gojkovic, Milos, Marklund, Emilia, Pietsch, Sandra, Foskolou, Iosifina, Branco, Cristina M, Veliça, Pedro, Johnson, Randall S
Published in Cancer immunology research (01.03.2023)
Published in Cancer immunology research (01.03.2023)
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The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome
Foskolou, Iosifina P., Barbieri, Laura, Vernet, Aude, Bargiela, David, Cunha, Pedro P., Velica, Pedro, Suh, Eunyeong, Pietsch, Sandra, Matuleviciute, Rugile, Rundqvist, Helene, McIntyre, Dominick, Smith, Ken G.C., Johnson, Randall S.
Published in Blood advances (22.09.2020)
Published in Blood advances (22.09.2020)
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Glutarate regulates T cell metabolism and anti-tumour immunity
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Published in Nature metabolism (2023)
Published in Nature metabolism (2023)
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