Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease
Forner, Stefania, Kawauchi, Shimako, Balderrama-Gutierrez, Gabriela, Kramár, Enikö A, Matheos, Dina P, Phan, Jimmy, Javonillo, Dominic I, Tran, Kristine M, Hingco, Edna, da Cunha, Celia, Rezaie, Narges, Alcantara, Joshua A, Baglietto-Vargas, David, Jansen, Camden, Neumann, Jonathan, Wood, Marcelo A, MacGregor, Grant R, Mortazavi, Ali, Tenner, Andrea J, LaFerla, Frank M, Green, Kim N
Published in Scientific data (15.10.2021)
Published in Scientific data (15.10.2021)
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Journal Article
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology
Baglietto-Vargas, David, Forner, Stefania, Cai, Lena, Martini, Alessandra C, Trujillo-Estrada, Laura, Swarup, Vivek, Nguyen, Marie Minh Thu, Do Huynh, Kelly, Javonillo, Dominic I, Tran, Kristine Minh, Phan, Jimmy, Jiang, Shan, Kramár, Enikö A, Nuñez-Diaz, Cristina, Balderrama-Gutierrez, Gabriela, Garcia, Franklin, Childs, Jessica, Rodriguez-Ortiz, Carlos J, Garcia-Leon, Juan Antonio, Kitazawa, Masashi, Shahnawaz, Mohammad, Matheos, Dina P, Ma, Xinyi, Da Cunha, Celia, Walls, Ken C, Ager, Rahasson R, Soto, Claudio, Gutierrez, Antonia, Moreno-Gonzalez, Ines, Mortazavi, Ali, Tenner, Andrea J, MacGregor, Grant R, Wood, Marcelo, Green, Kim N, LaFerla, Frank M
Published in Nature communications (23.04.2021)
Published in Nature communications (23.04.2021)
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Journal Article
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease
Javonillo, Dominic I, Tran, Kristine M, Phan, Jimmy, Hingco, Edna, Kramár, Enikö A, da Cunha, Celia, Forner, Stefania, Kawauchi, Shimako, Milinkeviciute, Giedre, Gomez-Arboledas, Angela, Neumann, Jonathan, Banh, Crystal E, Huynh, Michelle, Matheos, Dina P, Rezaie, Narges, Alcantara, Joshua A, Mortazavi, Ali, Wood, Marcelo A, Tenner, Andrea J, MacGregor, Grant R, Green, Kim N, LaFerla, Frank M
Published in Frontiers in neuroscience (24.01.2022)
Published in Frontiers in neuroscience (24.01.2022)
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Journal Article
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease
Trujillo-Estrada, Laura, Vanderklish, Peter W., Nguyen, Marie Minh Thu, Kuang, Run Rong, Nguyen, Caroline, Huynh, Eric, da Cunha, Celia, Javonillo, Dominic Ibarra, Forner, Stefania, Martini, Alessandra C., Sarraf, Stella T., Simmon, Vincent F., Baglietto-Vargas, David, LaFerla, Frank M.
Published in Neurotherapeutics (01.10.2021)
Published in Neurotherapeutics (01.10.2021)
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Journal Article
A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
Tran, Kristine M, Kawauchi, Shimako, Kramár, Enikö A, Rezaie, Narges, Liang, Heidi Yahan, Sakr, Jasmine S, Gomez-Arboledas, Angela, Arreola, Miguel A, Cunha, Celia da, Phan, Jimmy, Wang, Shuling, Collins, Sherilyn, Walker, Amber, Shi, Kai-Xuan, Neumann, Jonathan, Filimban, Ghassan, Shi, Zechuan, Milinkeviciute, Giedre, Javonillo, Dominic I, Tran, Katelynn, Gantuz, Magdalena, Forner, Stefania, Swarup, Vivek, Tenner, Andrea J, LaFerla, Frank M, Wood, Marcelo A, Mortazavi, Ali, MacGregor, Grant R, Green, Kim N
Published in Molecular neurodegeneration (17.02.2023)
Published in Molecular neurodegeneration (17.02.2023)
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Journal Article
VISCERAL ADIPOSE TISSUE TRIGGERS TAU PATHOGENESIS IN TRANSGENIC MICE TROUGH CDK5/P25 PATHWAY
Luque, Miriam Bettinetti, Trujillo-Estrada, Laura, Andreo-Lopez, Juana, Moreno, Cynthia Campos, Fatuarte-Juli, Ivan, Morales-Cabello, Mario, Da Cunha, Celia, Sanchez-Mejias, Elisabet, Laferla, Frank, Gutierrez, Antonia, Baglietto-Vargas, David
Published in IBRO neuroscience reports (01.10.2023)
Published in IBRO neuroscience reports (01.10.2023)
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Journal Article
HUMAN AND MOUSE SEEDS DIFFERENTIALLY AFFECT AΒ AGGREGATION BY MODULATING THE INFLAMMATORY RESPONSE
Andreo-Lopez, Juana, Cantero-Molina, Francisco, Bettinetti-Luque, Miriam, Huynh, Kelly, Nguyen, Marie, Cheung, Alwin, Tran, Janine, Da Cunha, Celia, Campos-Moreno, Cynthia, Morales-Cabello, Mario, Fatuarte-Juli, Ivan, Garcia-Leon, Juan Antonio, Trujillo-Estrada, Laura, Nuñez-Diaz, Cristina, Martini, Alessandra Cadete, Forner, Stefania, Laferla, Frank, Gutierrez, Antonia, Baglietto-Vargas, David
Published in IBRO neuroscience reports (01.10.2023)
Published in IBRO neuroscience reports (01.10.2023)
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Journal Article
Visceral adipose tissue triggers tau pathogenesis in transgenic mice
Bettinetti‐Luque, Miriam, Trujillo‐Estrada, Laura, Andreo‐Lopez, Juana, Cantero‐Molina, Francisco, Da Cunha, Celia, Sanchez‐Mejias, Elisabeth, LaFerla, Frank, Gutierrez, Antonia, Baglietto‐Vargas, David
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
Fat and the brain: its connection and implication in AD pathogenesis
Bettinetti‐Luque, Miriam, Trujillo‐Estrada, Laura, Andreo‐Lopez, Juana, Cantero‐Molina, Francisco, Da Cunha, Celia, Sanchez‐Mejias, Elisabeth, LaFerla, Frank, Gutierrez, Antonia, Baglietto‐Vargas, David
Published in Alzheimer's & dementia (01.06.2023)
Published in Alzheimer's & dementia (01.06.2023)
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Journal Article
A CLU/APOJ GWAS AD risk variant suppresses the astrocytic response to plaques and reduces axonal and neuritic damage in 5xFAD mice
Milinkeviciute, Giedre, Tran, Katelynn, Da Cunha, Celia, Mendoza‐Arvilla, Adrian, Garcia‐Agudo, Laura Fernandez, Neumann, Jonathan, Walker, Amber, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Martini, Alessandra Cadete, Gomez-Arboledas, Angela, Forner, Stefania, Rodriguez-Ortiz, Carlos J., McQuade, Amanda, Danhash, Emma, Phan, Jimmy, Javonillo, Dominic, Ha, Jordan-Vu, Tram, Melanie, Trujillo-Estrada, Laura, da Cunha, Celia, Ager, Rahasson R., Davila, Jose C., Kitazawa, Masashi, Blurton-Jones, Mathew, Gutierrez, Antonia, Baglietto-Vargas, David, Medeiros, Rodrigo, LaFerla, Frank M.
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2019)
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Journal Article
Trem2 R47H NSS; 5xFAD mice display age/disease progression‐dependent changes in plaques and plaque‐associated microglia, and increased plasma neurofilament light chain
Tran, Kristine M, Kawauchi, Shimako, Javonillo, Dominic I, Da Cunha, Celia, Phan, Jimmy, Rezaie, Narges, Liang, Heidi Yahan, Milinkeviciute, Giedre, Gomez‐Arboledas, Angela, Forner, Stefania, Mortazavi, Ali, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Late‐onset AD risk mutation PICALM H458R prevents plaque generation in 5xFAD mice
Gomez‐Arboledas, Angela, Tran, Kristine M, Javonillo, Dominic I, Phan, Jimmy, Milinkeviciute, Giedre, Da Cunha, Celia, Forner, Stefania, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Late‐onset AD risk mutation PICALMH458R prevents plaque generation in 5xFAD mice
Gomez‐Arboledas, Angela, Tran, Kristine M, Javonillo, Dominic I, Phan, Jimmy, Milinkeviciute, Giedre, Da Cunha, Celia, Forner, Stefania, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
ABCA7V1599M variant in 5xFAD mice mediates differences in amyloid‐beta pathology and reactive gliosis
Butler, Claire Ann, Javonillo, Dominic I, Houchin, Lauren A, Kawauchi, Shimako, Phan, Jimmy, Da Cunha, Celia, Tran, Katelynn, Milinkeviciute, Giedre, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
The Clu‐rs2279590_h2kb variant increases axonal and neuritic damage in 5xFAD mice
Milinkeviciute, Giedre, Tran, Katelynn, Tran, Kristine M, Phan, Jimmy, Da Cunha, Celia, Javonillo, Dominic I, Neumann, Jonathan, Alcantara, Joshua A, Walker, Amber, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Human and mouse seeds differentially affect Aβ aggregation by modulating the inflammatory response
Andreo‐Lopez, Juana, Cantero‐Molina, Francisco, Bettinetti‐Luque, Miriam, Huynh, Kelly Do, Nguyen, Marie Minh Thu, Cheung, Alwin, Tran, Janine Pham, Da Cunha, Celia, Trujillo‐Estrada, Laura, Nuñez‐Diaz, Cristina, Martini, Alessandra Cadete, Forner, Stefania, Gutierrez, Antonia, LaFerla, Frank, Baglietto‐Vargas, David
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
Human amyloid seeds induce a more profound pathology than seeds from old 3x‐Tg‐AD mice
Andreo‐Lopez, Juana, Cantero‐Molina, Francisco, Bettinetti‐Luque, Miriam, Huynh, Kelly Do, Nguyen, Marie Minh Thu, Cheung, Alwin, Tran, Janine Pham, Da Cunha, Celia, Trujillo‐Estrada, Laura, Nuñez‐Diaz, Cristina, Martini, Alessandra Cadete, Forner, Stefania, Gutierrez, Antonia, LaFerla, Frank, Baglietto‐Vargas, David
Published in Alzheimer's & dementia (01.06.2023)
Published in Alzheimer's & dementia (01.06.2023)
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Journal Article
Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models
Trujillo‐Estrada, Laura, Nguyen, Cassidy, da Cunha, Celia, Cai, Lena, Forner, Stefania, Martini, Alessandra C., Ager, Rahasson R., Prieto, Gilberto Aleph, Cotman, Carl W., Baglietto‐Vargas, David, LaFerla, Frank M.
Published in Aging cell (01.06.2019)
Published in Aging cell (01.06.2019)
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Journal Article
Accumulation of periodic‐acid Schiff granules is increased in the presence of humanized amyloid beta
Forner, Stefania, Javonillo, Dominic I, Tran, Kristine M, Phan, Jimmy, Da Cunha, Celia, Baglietto‐Vargas, David, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Journal Article