Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue
LEE, William A, HE, Gong-Xin, EISENBERG, Eugene, CIHLAR, Tomas, SWAMINATHAN, Swami, MULATO, Andrew, CUNDY, Kenneth C
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Published in Antimicrobial Agents and Chemotherapy (01.05.2005)
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Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin
Cundy, Kenneth C, Sastry, Srikonda, Luo, Wendy, Zou, Joan, Moors, Tristen L, Canafax, Daniel M
Published in Journal of clinical pharmacology (01.12.2008)
Published in Journal of clinical pharmacology (01.12.2008)
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Randomised clinical trial: arbaclofen placarbil in gastro‐oesophageal reflux disease – insights into study design for transient lower sphincter relaxation inhibitors
Vakil, N. B., Huff, F. J., Cundy, K. C.
Published in Alimentary pharmacology & therapeutics (01.07.2013)
Published in Alimentary pharmacology & therapeutics (01.07.2013)
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XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: II. Improved Oral Bioavailability, Dose Proportionality, and Colonic Absorption Compared with Gabapentin in Rats and Monkeys
Cundy, Kenneth C, Annamalai, Thamil, Bu, Lin, De Vera, Josephine, Estrela, Jenny, Luo, Wendy, Shirsat, Payal, Torneros, Allan, Yao, Fenmei, Zou, Joan, Barrett, Ronald W, Gallop, Mark A
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
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Population pharmacokinetics and pharmacodynamics of gabapentin after administration of gabapentin enacarbil
Lal, Ritu, Sukbuntherng, Juthamas, Luo, Wendy, Tovera, James, Lassauzet, Marie Liesse, Cundy, Kenneth C
Published in Journal of clinical pharmacology (01.01.2013)
Published in Journal of clinical pharmacology (01.01.2013)
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Arbaclofen Placarbil, a Novel R-Baclofen Prodrug: Improved Absorption, Distribution, Metabolism, and Elimination Properties Compared with R-Baclofen
Lal, Ritu, Sukbuntherng, Juthamas, Tai, Ezra H L, Upadhyay, Shubhra, Yao, Fenmei, Warren, Mark S, Luo, Wendy, Bu, Lin, Nguyen, Son, Zamora, Jeanelle, Peng, Ge, Dias, Tracy, Bao, Ying, Ludwikow, Maria, Phan, Thu, Scheuerman, Randall A, Yan, Hui, Gao, Mark, Wu, Quincey Q, Annamalai, Thamil, Raillard, Stephen P, Koller, Kerry, Gallop, Mark A, Cundy, Kenneth C
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters
Cundy, Kenneth C, Branch, Russell, Chernov-Rogan, Tania, Dias, Tracy, Estrada, Toño, Hold, Karin, Koller, Kerry, Liu, Xiaoli, Mann, Adam, Panuwat, Matt, Raillard, Stephen P, Upadhyay, Shubhra, Wu, Quincey Q, Xiang, Jia-Ning, Yan, Hui, Zerangue, Noa, Zhou, Cindy X, Barrett, Ronald W, Gallop, Mark A
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2004)
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Clinical Pharmacokinetics of Gabapentin After Administration of Gabapentin Enacarbil Extended-Release Tablets in Patients With Varying Degrees of Renal Function Using Data From an Open-Label, Single-Dose Pharmacokinetic Study
Lal, Ritu, PhD, Sukbuntherng, Juthamas, PhD, Luo, Wendy, MS, Chen, Dan, MD, PhD, Blumenthal, Robin, PhD, Ho, Judy, BS, Cundy, Kenneth C., PhD
Published in Clinical therapeutics (2012)
Published in Clinical therapeutics (2012)
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Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
WEIXING LI, ESCARPE, P. A, KIM, C. U, BISCHOFBERGER, N, CHEN, M. S, MENDEL, D. B, EISENBERG, E. J, CUNDY, K. C, SWEET, C, JAKEMAN, K. J, MERSON, J, LEW, W, WILLIAMS, M, LIJUN ZHANG
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
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Pharmacokinetics and tolerability of single escalating doses of gabapentin enacarbil: A randomized-sequence, double-blind, placebo-controlled crossover study in healthy volunteers
Lal, Ritu, PhD, Sukbuntherng, Juthamas, PhD, Luo, Wendy, MS, Chen, Dan, MD, PhD, Vu, Amanda, MS, Tovera, James, BS, Cundy, Kenneth C., PhD
Published in Clinical therapeutics (01.08.2009)
Published in Clinical therapeutics (01.08.2009)
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Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults
DEEKS, S. G, BARDITCH-CROVO, P, LIETMAN, P. S, HWANG, F, CUNDY, K. C, ROONEY, J. F, HELLMANN, N. S, SAFRIN, S, KAHN, J. O
Published in Antimicrobial Agents and Chemotherapy (01.09.1998)
Published in Antimicrobial Agents and Chemotherapy (01.09.1998)
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A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome
Lal, Ritu, Ellenbogen, Aaron, Chen, Dan, Zomorodi, Katie, Atluri, Harisha, Luo, Wendy, Tovera, James, Hurt, Janet, Bonzo, Daniel, Lassauzet, Marie-Liesse, Vu, Amanda, Cundy, Kenneth C
Published in Clinical neuropharmacology (01.07.2012)
Published in Clinical neuropharmacology (01.07.2012)
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Anti-Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-Infected Patients
Barditch-Crovo, P., Toole, J., Hendrix, C. W., Cundy, K. C., Ebeling, D., Jaffe, H. S., Lietman, P. S.
Published in The Journal of infectious diseases (01.08.1997)
Published in The Journal of infectious diseases (01.08.1997)
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Antiviral Efficacy and Pharmacokinetics of Oral Adefovir Dipivoxil in Chronically Woodchuck Hepatitis Virus-Infected Woodchucks
CULLEN, John M, LI, Daniel H, BROWN, Cynthia, EISENBERG, Eugene J, CUNDY, Kenneth C, WOLFE, Julie, TOOLE, J. A. Y, GIBBS, Craig
Published in Antimicrobial Agents and Chemotherapy (01.10.2001)
Published in Antimicrobial Agents and Chemotherapy (01.10.2001)
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