Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens
Cumming, John G., Kreis, Lukas, Kühne, Holger, Wermuth, Roger, Vercruysse, Maarten, Kramer, Christian, Rudolph, Markus G., Xu, Zhiheng
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Journal Article
Chemical predictive modelling to improve compound quality
Cumming, John G, Davis, Andrew M, Muresan, Sorel, Haeberlein, Markus, Chen, Hongming
Published in Nature reviews. Drug discovery (01.12.2013)
Published in Nature reviews. Drug discovery (01.12.2013)
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Journal Article
From mundane to surprising nonadditivity: drivers and impact on ML models
Guasch, Laura, Maeder, Niels, Cumming, John G., Kramer, Christian
Published in Journal of computer-aided molecular design (01.12.2024)
Published in Journal of computer-aided molecular design (01.12.2024)
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Journal Article
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase
CUMMING, John G, MCKENZIE, Caroline L, BOWDEN, Stuart G, CAMPBELL, Douglas, MASTERS, David J, BREED, Jason, JEWSBURY, Philip J
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Journal Article
Novel Indane-Containing NBTIs with Potent Anti-Gram-Negative Activity and Minimal hERG Inhibition
Cumming, John G., Kreis, Lukas, Kühne, Holger, Wermuth, Roger, Vercruysse, Maarten, Cantrill, Carina, Bissantz, Caterina, Qiu, Hongxia, Kramer, Christian, Andreotti, Daniele, Fossati, Giacomo
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Journal Article
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides
Cumming, John G., Cooper, Anne E., Grime, Ken, Logan, Chris J., McLaughlin, Sharon, Oldfield, John, Shaw, John S., Tucker, Howard, Winter, Jon, Whittaker, David
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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Journal Article
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis
Cumming, John G., Tucker, Howard, Oldfield, John, Fielding, Colin, Highton, Adrian, Faull, Alan, Wild, Martin, Brown, Dearg, Wells, Stuart, Shaw, John
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Automated QSAR with a Hierarchy of Global and Local Models
Wood, David J., Buttar, David, Cumming, John G., Davis, Andrew M., Norinder, Ulf, Rodgers, Sarah L.
Published in Molecular informatics (01.12.2011)
Published in Molecular informatics (01.12.2011)
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Journal Article
Discovery and Characterization of MAPK-activated Protein Kinase‑2 Prevention of Activation Inhibitors
Cumming, John G., Debreczeni, Judit É., Edfeldt, Fredrik, Evertsson, Emma, Harrison, Martin, Holdgate, Geoffrey A., James, Michael J., Lamont, Scott G., Oldham, Keith, Sullivan, Jane E., Wells, Stuart L.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Journal Article
Beyond the Scope of Free-Wilson Analysis. 2: Can Distance Encoded R‑Group Fingerprints Provide Interpretable Nonlinear Models?
Eriksson, Mats, Chen, Hongming, Carlsson, Lars, Nissink, J. Willem M, Cumming, John G, Nilsson, Ingemar
Published in Journal of chemical information and modeling (28.04.2014)
Published in Journal of chemical information and modeling (28.04.2014)
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Journal Article
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
Brown, Dearg S., Cumming, John G., Bethel, Paul, Finlayson, Jonathan, Gerhardt, Stefan, Nash, Ian, Pauptit, Richard A., Pike, Kurt G., Reid, Alan, Snelson, Wendy, Swallow, Steve, Thompson, Caroline
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Journal Article
Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis
De Savi, Chris, Pape, Andrew, Sawyer, Yvonne, Milne, David, Davies, Chris, Cumming, John G., Ting, Attilla, Lamont, Scott, Smith, Peter D., Tart, Jonathon, Page, Ken, Moore, Peter
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
De Savi, Chris, Pape, Andrew, Cumming, John G., Ting, Attilla, Smith, Peter D., Burrows, Jeremy N., Mills, Mark, Davies, Chris, Lamont, Scott, Milne, David, Cook, Calum, Moore, Peter, Sawyer, Yvonne, Gerhardt, Stefan
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
Total Synthesis of Swinholide A and Hemiswinholide A
Paterson, Ian, Yeung, Kap-Sun, Ward, Richard A, Cumming, John G, Smith, Julian D
Published in Journal of the American Chemical Society (01.10.1994)
Published in Journal of the American Chemical Society (01.10.1994)
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Journal Article
Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas
Burrows, Jeremy N., Cumming, John G., Fillery, Shaun M., Hamlin, Gordon A., Hudson, Julian A., Jackson, Ruth J., McLaughlin, Sharon, Shaw, John S.
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Journal Article
Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides
Cumming, John G., Brown, Simon J., Cooper, Anne E., Faull, Alan W., Flynn, Anthony P., Grime, Ken, Oldfield, John, Shaw, John S., Shepherd, Emma, Tucker, Howard, Whittaker, David
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Dynamically resolved peri-substituted 2-formyl naphthamides: a new class of atropisomeric chiral auxiliary
Clayden, Jonathan, McCarthy, Catherine, Cumming, John G
Published in Tetrahedron letters (29.04.2000)
Published in Tetrahedron letters (29.04.2000)
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Journal Article