Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
Beshore, Douglas C., Liverton, Nigel J., McIntyre, Charles J., Claiborne, Christopher F., Libby, Brian, Culberson, J. Christopher, Salata, Joseph J., Regan, Christopher P., Lynch, Joseph J., Kiss, Laszlo, Spencer, Robert H., Kane, Stephanie A., White, Rebecca B., Yeh, Suzie, Hartman, George D., Dinsmore, Christopher J.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles
Sanders, John M, Beshore, Douglas C, Culberson, J Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine
Crowley, Brendan M., Stump, Craig A., Nguyen, Diem N., Potteiger, Craig M., McWherter, Melody A., Paone, Daniel V., Quigley, Amy G., Bruno, Joseph G., Cui, Dan, Culberson, J. Christopher, Danziger, Andrew, Fandozzi, Christine, Gauvreau, Danny, Kemmerer, Amanda L., Menzel, Karsten, Moore, Eric L., Mosser, Scott D., Reddy, Vijay, White, Rebecca B., Salvatore, Christopher A., Kane, Stefanie A., Bell, Ian M., Selnick, Harold G., Fraley, Mark E., Burgey, Christopher S.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel
Karczewski, Jerzy, Wang, Jixin, Kane, Stefanie A., Kiss, Laszlo, Koblan, Kenneth S., Culberson, J. Christopher, Spencer, Robert H.
Published in Biochemical pharmacology (15.05.2009)
Published in Biochemical pharmacology (15.05.2009)
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Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score
Pertusi, Dante A., O’Donnell, Gregory, Homsher, Michelle F., Solly, Kelli, Patel, Amita, Stahler, Shannon L., Riley, Daniel, Finley, Michael F., Finger, Eleftheria N., Adam, Gregory C., Meng, Juncai, Bell, David J., Zuck, Paul D., Hudak, Edward M., Weber, Michael J., Nothstein, Jennifer E., Locco, Louis, Quinn, Carissa, Amoss, Adam, Squadroni, Brian, Hartnett, Michelle, Heo, Mee Ra, White, Tara, May, S. Alex, Boots, Evelyn, Roberts, Kenneth, Cocchiarella, Patrick, Wolicki, Alex, Kreamer, Anthony, Kutchukian, Peter S., Wassermann, Anne Mai, Uebele, Victor N., Glick, Meir, Rusinko, Andrew, Culberson, J. Christopher
Published in SLAS discovery (01.09.2017)
Published in SLAS discovery (01.09.2017)
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Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328
Harrison, Scott T, Mulhearn, James, Wolkenberg, Scott E, Miller, Patricia J, O’Malley, Stacey S, Zeng, Zhizhen, Williams, David L, Hostetler, Eric D, Sanabria-Bohórquez, Sandra, Gammage, Linda, Fan, Hong, Sur, Cyrille, Culberson, J. Christopher, Hargreaves, Richard J, Cook, Jacquelynn J, Hartman, George D, Barrow, James C
Published in ACS medicinal chemistry letters (14.07.2011)
Published in ACS medicinal chemistry letters (14.07.2011)
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Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases
Bell, Ian M, Stirdivant, Steven M, Ahern, Janet, Culberson, J. Christopher, Darke, Paul L, Dinsmore, Christopher J, Drakas, Robert A, Gallicchio, Steven N, Graham, Samuel L, Heimbrook, David C, Hall, Dawn L, Hua, Jin, Kett, Nathan R, Kim, Annette S, Kornienko, Maria, Kuo, Lawrence C, Munshi, Sanjeev K, Quigley, Amy G, Reid, John C, Trotter, B. Wesley, Waxman, Lloyd H, Williams, Theresa M, Zartman, C. Blair
Published in Biochemistry (Easton) (12.07.2005)
Published in Biochemistry (Easton) (12.07.2005)
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Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase
Dinsmore, Christopher J, Bogusky, Michael J, Culberson, J. Christopher, Bergman, Jeffrey M, Homnick, Carl F, Zartman, C. Blair, Mosser, Scott D, Schaber, Michael D, Robinson, Ronald G, Koblan, Kenneth S, Huber, Hans E, Graham, Samuel L, Hartman, George D, Huff, Joel R, Williams, Theresa M
Published in Journal of the American Chemical Society (07.03.2001)
Published in Journal of the American Chemical Society (07.03.2001)
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Reagent Selector: Using Synthon Analysis to Visualize Reagent Properties and Assist in Combinatorial Library Design
Mosley, Ralph T, Culberson, J. Christopher, Kraker, Bryan, Feuston, Bradley P, Sheridan, Robert P, Conway, John F, Forbes, Joseph K, Chakravorty, Subhas J, Kearsley, Simon K
Published in Journal of chemical information and modeling (01.09.2005)
Published in Journal of chemical information and modeling (01.09.2005)
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Web enabling technology for the design, enumeration, optimization and tracking of compound libraries
Feuston, Bradley P, Chakravorty, Subhas J, Conway, John F, Culberson, J Christopher, Forbes, Joseph, Kraker, Bryan, Lennon, Patricia A, Lindsley, Craig, McGaughey, Georgia B, Mosley, Ralph, Sheridan, Robert P, Valenciano, Mario, Kearsley, Simon K
Published in Current topics in medicinal chemistry (01.01.2005)
Published in Current topics in medicinal chemistry (01.01.2005)
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Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Dinsmore, Christopher J, Zartman, C.Blair, Bergman, Jeffrey M, Abrams, Marc T, Buser, Carolyn A, Culberson, J.Christopher, Davide, Joseph P, Ellis-Hutchings, Michelle, Fernandes, Christine, Graham, Samuel L, Hartman, George D, Huber, Hans E, Lobell, Robert B, Mosser, Scott D, Robinson, Ronald G, Williams, Theresa M
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Comparison of Knowledge-Based and Distance Geometry Approaches for Generation of Molecular Conformations
Feuston, Bradley P, Miller, Michael D, Culberson, J. Christopher, Nachbar, Robert B, Kearsley, Simon K
Published in Journal of Chemical Information and Computer Sciences (01.05.2001)
Published in Journal of Chemical Information and Computer Sciences (01.05.2001)
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Journal Article
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles: Miniperspective
Sanders, John M, Beshore, Douglas C, Culberson, J. Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency
Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beese, Lorena S, Beshore, Douglas C, Bhimnathwala, Hema, Bogusky, Michael J, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hamilton, Kelly A, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huber, Hans E, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Robinson, Ronald, Rodrigues, A. David, Taylor, Jeffrey S, Walsh, Eileen S, Williams, Theresa M, Zartman, C. Blair
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Journal Article
Molecular Model of the αIIbβ3 Integrin
Feuston, Bradley P, Culberson, J. Christopher, Hartman, George D
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Molecular Model of the α IIb β 3 Integrin
Feuston, Bradley P., Culberson, J. Christopher, Hartman, George D.
Published in Journal of medicinal chemistry (01.12.2003)
Published in Journal of medicinal chemistry (01.12.2003)
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Molecular model of the alpha(IIb)beta(3) integrin
Feuston, Bradley P, Culberson, J Christopher, Hartman, George D
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Journal Article
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
Dinsmore, Christopher J., Williams, Theresa M., O'Neill, Timothy J., Liu, Dongming, Rands, Elaine, Culberson, J.Christopher, Lobell, Robert B., Koblan, Kenneth S., Kohl, Nancy E., Gibbs, Jackson B., Oliff, Allen I., Graham, Samuel L., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
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