Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia
Berrien-Elliott, Melissa M., Cashen, Amanda F., Cubitt, Celia C., Neal, Carly C., Wong, Pamela, Wagner, Julia A., Foster, Mark, Schappe, Timothy, Desai, Sweta, McClain, Ethan, Becker-Hapak, Michelle, Foltz, Jennifer A., Cooper, Matthew L., Jaeger, Natalia, Srivatsan, Sridhar Nonavinkere, Gao, Feng, Romee, Rizwan, Abboud, Camille N., Uy, Geoffrey L., Westervelt, Peter, Jacoby, Meagan A., Pusic, Iskra, Stockerl-Goldstein, Keith E., Schroeder, Mark A., DiPersio, John, Fehniger, Todd A.
Published in Cancer discovery (01.12.2020)
Published in Cancer discovery (01.12.2020)
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Journal Article
Memory-like Differentiation Enhances NK Cell Responses to Melanoma
Marin, Nancy D, Krasnick, Bradley A, Becker-Hapak, Michelle, Conant, Leah, Goedegebuure, Simon P, Berrien-Elliott, Melissa M, Robbins, Keenan J, Foltz, Jennifer A, Foster, Mark, Wong, Pamela, Cubitt, Celia C, Tran, Jennifer, Wetzel, Christopher B, Jacobs, Miriam, Zhou, Alice Y, Russler-Germain, David, Marsala, Lynne, Schappe, Timothy, Fields, Ryan C, Fehniger, Todd A
Published in Clinical cancer research (01.09.2021)
Published in Clinical cancer research (01.09.2021)
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Journal Article
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
Berrien-Elliott, Melissa M, Foltz, Jennifer A, Russler-Germain, David A, Neal, Carly C, Tran, Jennifer, Gang, Margery, Wong, Pamela, Fisk, Bryan, Cubitt, Celia C, Marin, Nancy D, Zhou, Alice Y, Jacobs, Miriam T, Foster, Mark, Schappe, Timothy, McClain, Ethan, Kersting-Schadek, Samantha, Desai, Sweta, Pence, Patrick, Becker-Hapak, Michelle, Eisele, Jeremy, Mosior, Matthew, Marsala, Lynne, Griffith, Obi L, Griffith, Malachi, Khan, Saad M, Spencer, David H, DiPersio, John F, Romee, Rizwan, Uy, Geoffrey L, Abboud, Camille N, Ghobadi, Armin, Westervelt, Peter, Stockerl-Goldstein, Keith, Schroeder, Mark A, Wan, Fei, Lie, Wen-Rong, Soon-Shiong, Patrick, Petti, Allegra A, Cashen, Amanda F, Fehniger, Todd A
Published in Science translational medicine (23.02.2022)
Published in Science translational medicine (23.02.2022)
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Journal Article
T-BET and EOMES sustain mature human NK cell identity and antitumor function
Wong, Pamela, Foltz, Jennifer A, Chang, Lily, Neal, Carly C, Yao, Tony, Cubitt, Celia C, Tran, Jennifer, Kersting-Schadek, Samantha, Palakurty, Sathvik, Jaeger, Natalia, Russler-Germain, David A, Marin, Nancy D, Gang, Margery, Wagner, Julia A, Zhou, Alice Y, Jacobs, Miriam T, Foster, Mark, Schappe, Timothy, Marsala, Lynne, McClain, Ethan, Pence, Patrick, Becker-Hapak, Michelle, Fisk, Bryan, Petti, Allegra A, Griffith, Obi L, Griffith, Malachi, Berrien-Elliott, Melissa M, Fehniger, Todd A
Published in The Journal of clinical investigation (03.07.2023)
Published in The Journal of clinical investigation (03.07.2023)
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Journal Article
Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation
Cubitt, Celia C, Wong, Pamela, Dorando, Hannah K, Foltz, Jennifer A, Tran, Jennifer, Marsala, Lynne, Marin, Nancy D, Foster, Mark, Schappe, Timothy, Fatima, Hijab, Becker-Hapak, Michelle, Zhou, Alice Y, Hwang, Kimberly, Jacobs, Miriam T, Russler-Germain, David A, Mace, Emily M, Berrien-Elliott, Melissa M, Payton, Jacqueline E, Fehniger, Todd A
Published in The Journal of clinical investigation (01.08.2024)
Published in The Journal of clinical investigation (01.08.2024)
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Journal Article
MicroRNA-146a deficiency enhances host protection against murine cytomegalovirus
Wong, Pamela, Leong, Jeffrey W, Sohn, Hyogon, Chang, Lily, Keppel, Catherine R, Neal, Carly C, Cubitt, Celia C, Yao, Tony, Keppel, Molly P, Tran, Jennifer, Burdi, Allison, Hwang, Kimberly, Fogel, Leslie A, Schappe, Timothy, Marsala, Lynne, Berrien-Elliott, Melissa M, Wagner, Julia A, Schneider, Stephanie E, Sullivan, Ryan P, Pingel, Jeanette T, Cooper, Megan A, French, Anthony R, Fehniger, Todd A
Published in European journal of immunology (09.09.2024)
Published in European journal of immunology (09.09.2024)
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Journal Article
Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer
Jacobs, Miriam T, Wong, Pamela, Zhou, Alice Y, Becker-Hapak, Michelle, Marin, Nancy D, Marsala, Lynne, Foster, Mark, Foltz, Jennifer A, Cubitt, Celia C, Tran, Jennifer, Russler-Germain, David A, Neal, Carly, Kersting-Schadek, Samantha, Chang, Lily, Schappe, Timothy, Pence, Patrick, McClain, Ethan, Zevallos, Jose P, Rich, Jason T, Paniello, Randal C, Jackson, Ryan S, Pipkorn, Patrik, Adkins, Douglas R, DeSelm, Carl J, Berrien-Elliott, Melissa M, Puram, Sidharth V, Fehniger, Todd A
Published in Clinical cancer research (13.10.2023)
Published in Clinical cancer research (13.10.2023)
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Journal Article
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity
Wagner, Julia A., Wong, Pamela, Schappe, Timothy, Berrien-Elliott, Melissa M., Cubitt, Celia, Jaeger, Natalia, Lee, Madeline, Keppel, Cassie R., Marin, Nancy D., Foltz, Jennifer A., Marsala, Lynne, Neal, Carly C., Sullivan, Ryan P., Schneider, Stephanie E., Keppel, Molly P., Saucier, Nermina, Cooper, Megan A., Fehniger, Todd A.
Published in Cell reports (Cambridge) (02.06.2020)
Published in Cell reports (Cambridge) (02.06.2020)
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Journal Article
Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice
Shrestha, Niraj, Chaturvedi, Pallavi, Zhu, Xiaoyun, Dee, Michael J., George, Varghese, Janney, Christopher, Egan, Jack O., Liu, Bai, Foster, Mark, Marsala, Lynne, Wong, Pamela, Cubitt, Celia C., Foltz, Jennifer A., Tran, Jennifer, Schappe, Timothy, Hsiao, Karin, Leclerc, Gilles M., You, Lijing, Echeverri, Christian, Spanoudis, Catherine, Carvalho, Ana, Kanakaraj, Leah, Gilkes, Crystal, Encalada, Nicole, Kong, Lin, Wang, Meng, Fang, Byron, Wang, Zheng, Jiao, Jin‐an, Muniz, Gabriela J., Jeng, Emily K., Valdivieso, Nicole, Li, Liying, Deth, Richard, Berrien‐Elliott, Melissa M., Fehniger, Todd A., Rhode, Peter R., Wong, Hing C.
Published in Aging cell (01.05.2023)
Published in Aging cell (01.05.2023)
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Journal Article
Memory-like differentiation enhances NK cell responses against colorectal cancer
Marin, Nancy D, Becker-Hapak, Michelle, Song, Wilbur M, Alayo, Quazim A, Marsala, Lynne, Sonnek, Naomi, Berrien-Elliott, Melissa M, Foster, Mark, Foltz, Jennifer A, Tran, Jennifer, Wong, Pamela, Cubitt, Celia C, Pence, Patrick, Hwang, Kimberly, Zhou, Alice Y, Jacobs, Miriam T, Schappe, Timothy, Russler-Germain, David A, Fields, Ryan C, Ciorba, Matthew A, Fehniger, Todd A
Published in Oncoimmunology (2024)
Published in Oncoimmunology (2024)
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Journal Article
A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells
Cubitt, Celia C., McClain, Ethan, Becker-Hapak, Michelle, Foltz, Jennifer A., Wong, Pamela, Wagner, Julia A., Neal, Carly C., Marin, Nancy D., Marsala, Lynne, Foster, Mark, Schappe, Timothy, Soon-Shiong, Patrick, Lee, John, Berrien-Elliott, Melissa M., Fehniger, Todd A.
Published in Molecular therapy. Oncolytics (17.03.2022)
Published in Molecular therapy. Oncolytics (17.03.2022)
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Journal Article
Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation
Foltz, Jennifer A, Tran, Jennifer, Wong, Pamela, Fan, Changxu, Schmidt, Evelyn, Fisk, Bryan, Becker-Hapak, Michelle, Russler-Germain, David A, Johnson, Jeanette, Marin, Nancy D, Cubitt, Celia C, Pence, Patrick, Rueve, Joseph, Pureti, Sushanth, Hwang, Kimberly, Gao, Feng, Zhou, Alice Y, Foster, Mark, Schappe, Timothy, Marsala, Lynne, Berrien-Elliott, Melissa M, Cashen, Amanda F, Bednarski, Jeffrey J, Fertig, Elana, Griffith, Obi L, Griffith, Malachi, Wang, Ting, Petti, Allegra A, Fehniger, Todd A
Published in Science immunology (28.06.2024)
Published in Science immunology (28.06.2024)
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Journal Article
Combined IL-12, IL-15 and IL-18 activation induces epigenetic changes in human NK cells during the memory-like state transition
Tran, Jennifer, Wong, Pamela, Fan, Changxu, Russler-Germain, David, Cubitt, Celia C, Marin, Nancy D, Schappe, Timothy, Berrien-Elliott, Melissa, Wang, Ting, Foltz, Jennifer A, Fehniger, Todd A
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
CD8α identifies human NK cells with altered proliferation, metabolism, and IL-15 signaling
Cubitt, Celia, Wong, Pamela, Tran, Jennifer, Foltz, Jennifer Ann, Marin, Nancy D., Marsala, Lynne, Foster, Mark, Schappe, Timothy, Berrien-Elliott, Melissa M., Fehniger, Todd A
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
Induced CD8[alpha] identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation
Cubitt, Celia C, Wong, Pamela, Dorando, Hannah K, Foltz, Jennifer A, Tran, Jennifer, Marsala, Lynne, Marin, Nancy D, Foster, Mark, Schappe, Timothy, Fatima, Hijab, Becker-Hapak, Michelle, Zhou, Alice Y, Hwang, Kimberly, Jacobs, Miriam T, Russler-Germain, David A, Mace, Emily M, Berrien-Elliott, Melissa M, Payton, Jacqueline E, Fehniger, Todd A
Published in The Journal of clinical investigation (01.08.2024)
Published in The Journal of clinical investigation (01.08.2024)
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Journal Article
T-box transcription factors Eomes and T-bet regulate primary human NK cell IFNγ response and in vivo persistence
Wong, Pamela, Chang, Lily, Neal, Carly C, Wagner, Julia A, Berrien-Elliott, Melissa M, Cubitt, Celia C, Tran, Jennifer, Marsala, Lynne, Schappe, Timothy, Fehniger, Todd A
Published in The Journal of immunology (1950) (01.05.2021)
Published in The Journal of immunology (1950) (01.05.2021)
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Journal Article
Mechanisms of Cytokine-Induced NK Cell Therapy: IL-12/15/18 Induce a Unique Transcriptional, Epigenetic, and Functional Human NK Cell Memory Program
Tran, Jennifer, Foltz, Jennifer Ann, Wong, Pamela, Fan, Changxu, Becker-Hapak, Michelle, Marin, Nancy D, Cubitt, Celia C, Russler-Germain, David A, Foster, Mark, Schappe, Timothy, Marsala, Lynne, Rueve, Joseph, Hwang, Kimberly, Wang, Ting, Berrien-Elliott, Melissa M, Cashen, Amanda F, Bednarski, Jeffrey J., Griffith, Obi, Griffith, Malachi, Petti, Allegra, Fehniger, Todd A
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Eomes and T-Bet Expression Are Required By Mature Primary Human NK Cells for Anti-Leukemia Responses In Vivo
Wong, Pamela, Neal, Carly C., Chang, Lily, Wagner, Julia A, Berrien-Elliott, Melissa M., Cubitt, Celia C., Tran, Jennifer, Russler-Germain, David A., Marin, Nancy D., Foltz-Stringfellow, Jennifer A, Marsala, Lynne, Schappe, Timothy, Fehniger, Todd A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Brief IL-12, IL-15, IL-18 activation drives the acquisition of two distinct memory-like NK cell states
Foltz, Jennifer Ann, Tran, Jennifer, Fisk, Bryan, Wong, Pamela, Khan, Saad M., Berrien-Elliott, Melissa M., Becker-Hapak, Michelle, Russler-Germain, David A., Marsala, Lynne, Bednarski, Jeffrey J., Zimmerman, Clare, Cubitt, Celia C., Marin, Nancy D., Zhou, Alice Y., Jacobs, Miriam T., Foster, Mark, Schappe, Timothy, Pence, Patrick, Cashen, Amanda, Griffith, Obi L., Griffith, Malachi, Petti, Allegra A., Fehniger, Todd A
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
Cytokine-Induced Memory-like NK Cells Have a Distinct Single Cell Transcriptional Profile and Persist for Months in Adult and Pediatric Leukemia Patients after Adoptive Transfer
Foltz, Jennifer A., Berrien-Elliott, Melissa M., Russler-Germain, David A., Neal, Carly C., Tran, Jennifer, Gang, Margery, Wong, Pamela, Mosior, Matthew, Bednarski, Jeffrey J., Zimmerman, Clare, Cubitt, Celia C., Marin, Nancy D., Zhou, Alice Y., Jacobs, Miriam T., Foster, Mark, Schappe, Timothy, McClain, Ethan, Desai, Sweta, Pence, Patrick, Becker-Hapak, Michelle, Marsala, Lynne, Griffith, Obi L., Griffith, Malachi, Khan, Saad M., Fisk, Bryan, Cashen, Amanda F., Petti, Allegra A., Fehniger, Todd A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article