BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
Rodriguez, Diego A, Zamorano, Sebastian, Lisbona, Fernanda, Rojas‐Rivera, Diego, Urra, Hery, Cubillos‐Ruiz, Juan R, Armisen, Ricardo, Henriquez, Daniel R, Cheng, Emily H, Letek, Michal, Vaisar, Tomas, Irrazabal, Thergiory, Gonzalez‐Billault, Christian, Letai, Anthony, Pimentel‐Muiños, Felipe X, Kroemer, Guido, Hetz, Claudio
Published in The EMBO journal (15.09.2021)
Published in The EMBO journal (15.09.2021)
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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
Mandula, Jessica K., Chang, Shiun, Mohamed, Eslam, Jimenez, Rachel, Sierra-Mondragon, Rosa A., Chang, Darwin C., Obermayer, Alyssa N., Moran-Segura, Carlos M., Das, Satyajit, Vazquez-Martinez, Julio A., Prieto, Karol, Chen, Ann, Smalley, Keiran S.M., Czerniecki, Brian, Forsyth, Peter, Koya, Richard C., Ruffell, Brian, Cubillos-Ruiz, Juan R., Munn, David H., Shaw, Timothy I., Conejo-Garcia, Jose R., Rodriguez, Paulo C.
Published in Cancer cell (10.10.2022)
Published in Cancer cell (10.10.2022)
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Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer
Paffenholz, Stella V, Salvagno, Camilla, Ho, Yu-Jui, Limjoco, Matthew, Baslan, Timour, Tian, Sha, Kulick, Amanda, de Stanchina, Elisa, Wilkinson, John E, Barriga, Francisco M, Zamarin, Dmitriy, Cubillos-Ruiz, Juan R, Leibold, Josef, Lowe, Scott W
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2022)
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ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
Cao, Yu, Trillo-Tinoco, Jimena, Sierra, Rosa A., Anadon, Carmen, Dai, Wenjie, Mohamed, Eslam, Cen, Ling, Costich, Tara L., Magliocco, Anthony, Marchion, Douglas, Klar, Richard, Michel, Sven, Jaschinski, Frank, Reich, Richard R., Mehrotra, Shikhar, Cubillos-Ruiz, Juan R., Munn, David H., Conejo-Garcia, Jose R., Rodriguez, Paulo C.
Published in Nature communications (20.03.2019)
Published in Nature communications (20.03.2019)
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Ovarian cancer progression is controlled by phenotypic changes in dendritic cells
Scarlett, Uciane K, Rutkowski, Melanie R, Rauwerdink, Adam M, Fields, Jennifer, Escovar-Fadul, Ximena, Baird, Jason, Cubillos-Ruiz, Juan R, Jacobs, Ana C, Gonzalez, Jorge L, Weaver, John, Fiering, Steven, Conejo-Garcia, Jose R
Published in The Journal of experimental medicine (12.03.2012)
Published in The Journal of experimental medicine (12.03.2012)
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State-of-the-art of regulatory dendritic cells in cancer
Conejo-Garcia, Jose R, Rutkowski, Melanie R, Cubillos-Ruiz, Juan R
Published in Pharmacology & therapeutics (Oxford) (01.08.2016)
Published in Pharmacology & therapeutics (Oxford) (01.08.2016)
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Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer
Crowley, Michael J. P., Bhinder, Bhavneet, Markowitz, Geoffrey J., Martin, Mitchell, Verma, Akanksha, Sandoval, Tito A., Chae, Chang-Suk, Yomtoubian, Shira, Hu, Yang, Chopra, Sahil, Tavarez, Diamile A., Giovanelli, Paolo, Gao, Dingcheng, McGraw, Timothy E., Altorki, Nasser K., Elemento, Olivier, Cubillos-Ruiz, Juan R., Mittal, Vivek
Published in Nature communications (09.01.2023)
Published in Nature communications (09.01.2023)
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Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms
Morales, Diana K., Jacobs, Nicholas J., Rajamani, Sathish, Krishnamurthy, Malathy, Cubillos‐Ruiz, Juan R., Hogan, Deborah A.
Published in Molecular microbiology (01.12.2010)
Published in Molecular microbiology (01.12.2010)
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Reprogramming Tumor-Associated Dendritic Cells In Vivo Using miRNA Mimetics Triggers Protective Immunity against Ovarian Cancer
CUBILLOS-RUIZ, Juan R, BAIRD, Jason R, SEMPERE, Lorenzo F, CONEJO-GARCIA, Jose R, TESONE, Amelia J, RUTKOWSKI, Melanie R, SCARLETT, Uciane K, CAMPOSECO-JACOBS, Ana L, ANADON-ARNILLAS, Jorge, HARWOOD, Noah M, KORC, Murray, FIERING, Steven N
Published in Cancer research (Chicago, Ill.) (01.04.2012)
Published in Cancer research (Chicago, Ill.) (01.04.2012)
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Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis
Awasthi, Deepika, Chopra, Sahil, Cho, Byuri A, Emmanuelli, Alexander, Sandoval, Tito A, Hwang, Sung-Min, Chae, Chang-Suk, Salvagno, Camilla, Tan, Chen, Vasquez-Urbina, Liliana, Fernandez Rodriguez, Jose J, Santagostino, Sara F, Iwawaki, Takao, Romero-Sandoval, E Alfonso, Crespo, Mariano Sanchez, Morales, Diana K, Iliev, Iliyan D, Hohl, Tobias M, Cubillos-Ruiz, Juan R
Published in The Journal of clinical investigation (01.09.2023)
Published in The Journal of clinical investigation (01.09.2023)
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Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress
Ramos, Yusibeska, Sansone, Stephanie, Hwang, Sung-Min, Sandoval, Tito A, Zhu, Mengmeng, Zhang, Guoan, Cubillos-Ruiz, Juan R, Morales, Diana K
Published in mBio (20.12.2022)
Published in mBio (20.12.2022)
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High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils
Emmanuelli, Alexander, Salvagno, Camilla, Hwang, Sung-Min, Awasthi, Deepika, Sandoval, Tito A., Chae, Chang-Suk, Cheong, Jin-Gyu, Tan, Chen, Iwawaki, Takao, Cubillos-Ruiz, Juan R.
Published in Oncoimmunology (31.12.2024)
Published in Oncoimmunology (31.12.2024)
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Journal Article
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
Rodriguez, Diego A, Zamorano, Sebastian, Lisbona, Fernanda, Rojas-Rivera, Diego, Urra, Hery, Cubillos-Ruiz, Juan R, Armisen, Ricardo, Henriquez, Daniel R, H Cheng, Emily, Letek, Michal, Vaisar, Tomas, Irrazabal, Thergiory, Gonzalez-Billault, Christian, Letai, Anthony, Pimentel-Muiños, Felipe X, Kroemer, Guido, Hetz, Claudio
Published in The EMBO journal (16.05.2012)
Published in The EMBO journal (16.05.2012)
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Journal Article
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
Cubillos-Ruiz, Juan R, Engle, Xavier, Scarlett, Uciane K, Martinez, Diana, Barber, Amorette, Elgueta, Raul, Wang, Li, Nesbeth, Yolanda, Durant, Yvon, Gewirtz, Andrew T, Sentman, Charles L, Kedl, Ross, Conejo-Garcia, Jose R
Published in The Journal of clinical investigation (01.08.2009)
Published in The Journal of clinical investigation (01.08.2009)
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PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis
Ramos, Yusibeska, Rocha, Jorge, Hael, Ana L, van Gestel, Jordi, Vlamakis, Hera, Cywes-Bentley, Colette, Cubillos-Ruiz, Juan R, Pier, Gerald B, Gilmore, Michael S, Kolter, Roberto, Morales, Diana K
Published in PLoS pathogens (01.02.2019)
Published in PLoS pathogens (01.02.2019)
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ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis
Cubillos-Ruiz, Juan R., Silberman, Pedro C., Rutkowski, Melanie R., Chopra, Sahil, Perales-Puchalt, Alfredo, Song, Minkyung, Zhang, Sheng, Bettigole, Sarah E., Gupta, Divya, Holcomb, Kevin, Ellenson, Lora H., Caputo, Thomas, Lee, Ann-Hwee, Conejo-Garcia, Jose R., Glimcher, Laurie H.
Published in Cell (18.06.2015)
Published in Cell (18.06.2015)
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Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns
Márquez, Saioa, Fernández, José Javier, Mancebo, Cristina, Herrero-Sánchez, Carmen, Alonso, Sara, Sandoval, Tito A., Rodríguez Prados, Macarena, Cubillos-Ruiz, Juan R., Montero, Olimpio, Fernández, Nieves, Sánchez Crespo, Mariano
Published in Cell reports (Cambridge) (09.04.2019)
Published in Cell reports (Cambridge) (09.04.2019)
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