High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping
Czerniecki, Stefan M., Cruz, Nelly M., Harder, Jennifer L., Menon, Rajasree, Annis, James, Otto, Edgar A., Gulieva, Ramila E., Islas, Laura V., Kim, Yong Kyun, Tran, Linh M., Martins, Timothy J., Pippin, Jeffrey W., Fu, Hongxia, Kretzler, Matthias, Shankland, Stuart J., Himmelfarb, Jonathan, Moon, Randall T., Paragas, Neal, Freedman, Benjamin S.
Published in Cell stem cell (01.06.2018)
Published in Cell stem cell (01.06.2018)
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Journal Article
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease
Cruz, Nelly M., Song, Xuewen, Czerniecki, Stefan M., Gulieva, Ramila E., Churchill, Angela J., Kim, Yong Kyun, Winston, Kosuke, Tran, Linh M., Diaz, Marco A., Fu, Hongxia, Finn, Laura S., Pei, York, Himmelfarb, Jonathan, Freedman, Benjamin S.
Published in Nature materials (01.11.2017)
Published in Nature materials (01.11.2017)
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Journal Article
Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease
Li, Sienna R., Gulieva, Ramila E., Helms, Louisa, Cruz, Nelly M., Vincent, Thomas, Fu, Hongxia, Himmelfarb, Jonathan, Freedman, Benjamin S.
Published in Nature communications (23.12.2022)
Published in Nature communications (23.12.2022)
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Journal Article
Gene‐Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development
Kim, Yong Kyun, Refaeli, Ido, Brooks, Craig R., Jing, Peifeng, Gulieva, Ramila E., Hughes, Michael R., Cruz, Nelly M., Liu, Yannan, Churchill, Angela J., Wang, Yuliang, Fu, Hongxia, Pippin, Jeffrey W., Lin, Lih Y., Shankland, Stuart J., Vogl, A. Wayne, McNagny, Kelly M., Freedman, Benjamin S.
Published in Stem cells (Dayton, Ohio) (01.12.2017)
Published in Stem cells (Dayton, Ohio) (01.12.2017)
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Journal Article
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator
Sansam, Christopher L, Cruz, Nelly M, Danielian, Paul S, Amsterdam, Adam, Lau, Melissa L, Hopkins, Nancy, Lees, Jacqueline A
Published in Genes & development (15.01.2010)
Published in Genes & development (15.01.2010)
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Journal Article
Modifier genes as therapeutics: the nuclear hormone receptor Rev Erb alpha (Nr1d1) rescues Nr2e3 associated retinal disease
Cruz, Nelly M, Yuan, Yang, Leehy, Barrett D, Baid, Rinku, Kompella, Uday, DeAngelis, Margaret M, Escher, Pascal, Haider, Neena B
Published in PloS one (31.01.2014)
Published in PloS one (31.01.2014)
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Journal Article
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis
Gopalan, Janani, Omar, Mitchell H, Roy, Ankita, Cruz, Nelly M, Falcone, Jerome, Jones, Kiana N, Forbush, Katherine A, Himmelfarb, Jonathan, Freedman, Benjamin S, Scott, John D
Published in eLife (12.07.2021)
Published in eLife (12.07.2021)
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Journal Article
Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV
Grishchuk, Yulia, Stember, Katherine G, Matsunaga, Aya, Olivares, Ana M, Cruz, Nelly M, King, Victoria E, Humphrey, Daniel M, Wang, Shirley L, Muzikansky, Alona, Betensky, Rebecca A, Thoreson, Wallace B, Haider, Neena, Slaugenhaupt, Susan A
Published in The American journal of pathology (2016)
Published in The American journal of pathology (2016)
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Journal Article
Lessons on transparency from the glassfrog
Cruz, Nelly M, White, Richard M
Published in Science (American Association for the Advancement of Science) (23.12.2022)
Published in Science (American Association for the Advancement of Science) (23.12.2022)
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Journal Article
hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease
Fan, Yujie, Hackland, James, Baggiolini, Arianna, Hung, Lin Y., Zhao, Huiyong, Zumbo, Paul, Oberst, Polina, Minotti, Andrew P., Hergenreder, Emiliano, Najjar, Sarah, Huang, Zixing, Cruz, Nelly M., Zhong, Aaron, Sidharta, Mega, Zhou, Ting, de Stanchina, Elisa, Betel, Doron, White, Richard M., Gershon, Michael, Margolis, Kara Gross, Studer, Lorenz
Published in Cell stem cell (02.03.2023)
Published in Cell stem cell (02.03.2023)
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Journal Article
Optical tweezers system for live stem cell organization at the single-cell level
Jing, Peifeng, Liu, Yannan, Keeler, Ethan G, Cruz, Nelly M, Freedman, Benjamin S, Lin, Lih Y
Published in Biomedical optics express (01.02.2018)
Published in Biomedical optics express (01.02.2018)
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Journal Article
GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Tagore, Mohita, Hergenreder, Emiliano, Perlee, Sarah C, Cruz, Nelly M, Menocal, Laura, Suresh, Shruthy, Chan, Eric, Baron, Maayan, Melendez, Stephanie, Dave, Asim, Chatila, Walid K, Nsengimana, Jeremie, Koche, Richard P, Hollmann, Travis J, Ideker, Trey, Studer, Lorenz, Schietinger, Andrea, White, Richard M
Published in Cancer discovery (05.10.2023)
Published in Cancer discovery (05.10.2023)
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Journal Article
Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Suresh, Shruthy, Rabbie, Roy, Garg, Manik, Lumaquin, Dianne, Huang, Ting-Hsiang, Montal, Emily, Ma, Yilun, Cruz, Nelly M, Tang, Xinran, Nsengimana, Jérémie, Newton-Bishop, Julia, Hunter, Miranda V, Zhu, Yuxin, Chen, Kevin, de Stanchina, Elisa, Adams, David J, White, Richard M
Published in Cancer discovery (09.01.2023)
Published in Cancer discovery (09.01.2023)
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Journal Article
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia
Cruz, Nelly M., Reddy, Raghava, McFaline-Figueroa, José L., Tran, Christine, Fu, Hongxia, Freedman, Benjamin S.
Published in Nature biomedical engineering (01.04.2022)
Published in Nature biomedical engineering (01.04.2022)
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Journal Article
Author Correction: Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia
Cruz, Nelly M., Reddy, Raghava, McFaline-Figueroa, José L., Tran, Christine, Fu, Hongxia, Freedman, Benjamin S.
Published in Nature biomedical engineering (01.09.2022)
Published in Nature biomedical engineering (01.09.2022)
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Journal Article
Anatomic position determines oncogenic specificity in melanoma
Weiss, Joshua M., Hunter, Miranda V., Cruz, Nelly M., Baggiolini, Arianna, Tagore, Mohita, Ma, Yilun, Misale, Sandra, Marasco, Michelangelo, Simon-Vermot, Theresa, Campbell, Nathaniel R., Newell, Felicity, Wilmott, James S., Johansson, Peter A., Thompson, John F., Long, Georgina V., Pearson, John V., Mann, Graham J., Scolyer, Richard A., Waddell, Nicola, Montal, Emily D., Huang, Ting-Hsiang, Jonsson, Philip, Donoghue, Mark T. A., Harris, Christopher C., Taylor, Barry S., Xu, Tianhao, Chaligné, Ronan, Shliaha, Pavel V., Hendrickson, Ronald, Jungbluth, Achim A., Lezcano, Cecilia, Koche, Richard, Studer, Lorenz, Ariyan, Charlotte E., Solit, David B., Wolchok, Jedd D., Merghoub, Taha, Rosen, Neal, Hayward, Nicholas K., White, Richard M.
Published in Nature (London) (14.04.2022)
Published in Nature (London) (14.04.2022)
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Journal Article
Biobank of Urinary Cells and Human Kidney Organoids Reveals Nephropathic Cystinosis Phenotypes and Gene Therapy Strategy: PO1597
Helms, Louisa, Gomez, Ivan G., David, Dries, Cruz, Nelly M., Levtchenko, Elena N., Gijsbers, Rik, Freedman, Benjamin S.
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Journal Article
High-throughput automation enhances kidney organoid differentiation from human pluripotent stem cells and enables multidimensional phenotypic screening
Czerniecki, Stefan M., Cruz, Nelly M., Harder, Jennifer L., Menon, Rajasree, Annis, James, Otto, Edgar A., Gulieva, Ramila E., Islas, Laura V., Kim, Yong Kyun, Tran, Linh M., Martins, Timothy J., Pippin, Jeffrey W., Fu, Hongxia, Kretzler, Matthias, Shankland, Stuart J., Himmelfarb, Jonathan, Moon, Randall T., Paragas, Neal A., Freedman, Benjamin S.
Published in Cell stem cell (17.05.2018)
Published in Cell stem cell (17.05.2018)
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