Development and Mechanism of γ‑Secretase Modulators for Alzheimer’s Disease
Crump, Christina J, Johnson, Douglas S, Li, Yue-Ming
Published in Biochemistry (Easton) (14.05.2013)
Published in Biochemistry (Easton) (14.05.2013)
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Journal Article
γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin
Pozdnyakov, Nikolay, Murrey, Heather E., Crump, Christina J., Pettersson, Martin, Ballard, T.Eric, am Ende, Christopher W., Ahn, Kwangwook, Li, Yue-Ming, Bales, Kelly R., Johnson, Douglas S.
Published in The Journal of biological chemistry (05.04.2013)
Published in The Journal of biological chemistry (05.04.2013)
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Journal Article
Dual Role of α-Secretase Cleavage in the Regulation of γ-Secretase Activity for Amyloid Production
Tian, Yuan, Crump, Christina J., Li, Yue-Ming
Published in The Journal of biological chemistry (15.10.2010)
Published in The Journal of biological chemistry (15.10.2010)
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Journal Article
Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ‑Secretase
Crump, Christina J, Murrey, Heather E, Ballard, T. Eric, am Ende, Christopher W, Wu, Xianzhong, Gertsik, Natalya, Johnson, Douglas S, Li, Yue-Ming
Published in ACS chemical neuroscience (17.08.2016)
Published in ACS chemical neuroscience (17.08.2016)
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Journal Article
Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1
Crump, Christina J, Fish, Benjamin A, Castro, Suita V, Chau, De-Ming, Gertsik, Natalya, Ahn, Kwangwook, Stiff, Cory, Pozdnyakov, Nikolay, Bales, Kelly R, Johnson, Douglas S, Li, Yue-Ming
Published in ACS chemical neuroscience (21.12.2011)
Published in ACS chemical neuroscience (21.12.2011)
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Journal Article
Development of clickable active site-directed photoaffinity probes for γ-secretase
Crump, Christina J., am Ende, Christopher W., Eric Ballard, T., Pozdnyakov, Nikolay, Pettersson, Martin, Chau, De-Ming, Bales, Kelly R., Li, Yue-Ming, Johnson, Douglas S.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity
Crump, Christina J, Castro, Suita V, Wang, Feng, Pozdnyakov, Nikolay, Ballard, T. Eric, Sisodia, Sangram S, Bales, Kelly R, Johnson, Douglas S, Li, Yue-Ming
Published in Biochemistry (Easton) (18.09.2012)
Published in Biochemistry (Easton) (18.09.2012)
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Journal Article
Effect of the components of gamma-secretase on activity and specificity
Crump, Christina J, Sisodia, Sangram S, Li, Yue-Ming
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Development and Mechanism of γ-Secretase Modulators for Alzheimer Disease
Crump, Christina J., Johnson, Douglas S., Li, Yue-Ming
Published in Biochemistry (Easton) (02.05.2013)
Published in Biochemistry (Easton) (02.05.2013)
Get full text
Journal Article
Dual Role of a-Secretase Cleavage in the Regulation of g-Secretase Activity for Amyloid Production
Tian, Yuan, Crump, Christina J, Li, Yue-Ming
Published in The Journal of biological chemistry (01.10.2010)
Published in The Journal of biological chemistry (01.10.2010)
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Journal Article
P2‐270: Effect of the components of gamma‐secretase on activity and specificity
Crump, Christina J., Sisodia, Sangram S., Li, Yue-Ming
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Development of clickable active site-directed photoaffinity probes for I3-secretase
Crump, Christina J, am Ende, Christopher W, Eric Ballard, T, Pozdnyakov, Nikolay, Pettersson, Martin, Chau, De-Ming, Bales, Kelly R, Li, Yue-Ming, Johnson, Douglas S
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Development and Mechanism of -Secretase Modulators for Alzheimers Disease
Crump, Christina J, Johnson Douglas S.authorNeuroscience Medicinal Chemistry and Chemical Biology, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States, Li Yue-MingauthorMolecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United StatesDepartment of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, United States
Year of Publication 2015
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Year of Publication 2015
Journal Article
BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity
Crump, Christina J, Castro Suita V.authorDepartment of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, United States, Wang FengauthorDepartment of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, United States, Pozdnyakov NikolayauthorPfizer Worldwide Research and Development, 700 Main Street, Cambridge, Massachusetts 02139, United States, Ballard T. EricauthorPfizer Worldwide Research and Development, 700 Main Street, Cambridge, Massachusetts 02139, United States, Sisodia Sangram S.authorThe Center for Molecular Neurobiology, The University of Chicago, 947 East 58th Street, MC 0926, Chicago, Illinois 60637, United States, Bales Kelly R.authorPfizer Worldwide Research and Development, 700 Main Street, Cambridge, Massachusetts 02139, United States, Johnson Douglas S.authorPfizer Worldwide Research and Development, 700 Main Street, Cambridge, Massachusetts 02139, United States, Li Yue-MingauthorMolecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United StatesDepartment of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, United States
Year of Publication 2015
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Year of Publication 2015
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