TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
Cignarella, Francesca, Filipello, Fabia, Bollman, Bryan, Cantoni, Claudia, Locca, Alberto, Mikesell, Robert, Manis, Melissa, Ibrahim, Adiljan, Deng, Li, Benitez, Bruno A., Cruchaga, Carlos, Licastro, Danilo, Mihindukulasuriya, Kathie, Harari, Oscar, Buckland, Michael, Holtzman, David M., Rosenthal, Arnon, Schwabe, Tina, Tassi, Ilaria, Piccio, Laura
Published in Acta neuropathologica (01.10.2020)
Published in Acta neuropathologica (01.10.2020)
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Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Yang, Chengran, Farias, Fabiana H. G., Ibanez, Laura, Suhy, Adam, Sadler, Brooke, Fernandez, Maria Victoria, Wang, Fengxian, Bradley, Joseph L., Eiffert, Brett, Bahena, Jorge A., Budde, John P., Li, Zeran, Dube, Umber, Sung, Yun Ju, Mihindukulasuriya, Kathie A., Morris, John C., Fagan, Anne M., Perrin, Richard J., Benitez, Bruno A., Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos
Published in Nature neuroscience (01.09.2021)
Published in Nature neuroscience (01.09.2021)
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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
Kober, Daniel L, Alexander-Brett, Jennifer M, Karch, Celeste M, Cruchaga, Carlos, Colonna, Marco, Holtzman, Michael J, Brett, Thomas J
Published in eLife (20.12.2016)
Published in eLife (20.12.2016)
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Journal Article
Assessment of Racial Disparities in Biomarkers for Alzheimer Disease
Morris, John C, Schindler, Suzanne E, McCue, Lena M, Moulder, Krista L, Benzinger, Tammie L S, Cruchaga, Carlos, Fagan, Anne M, Grant, Elizabeth, Gordon, Brian A, Holtzman, David M, Xiong, Chengjie
Published in Archives of neurology (Chicago) (01.03.2019)
Published in Archives of neurology (Chicago) (01.03.2019)
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Cell specific peripheral immune responses predict survival in critical COVID-19 patients
Amrute, Junedh M., Perry, Alexandra M., Anand, Gautam, Cruchaga, Carlos, Hock, Karl G., Farnsworth, Christopher W., Randolph, Gwendalyn J., Lavine, Kory J., Steed, Ashley L.
Published in Nature communications (15.02.2022)
Published in Nature communications (15.02.2022)
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Coding variants in TREM2 increase risk for Alzheimer's disease
Jin, Sheng Chih, Benitez, Bruno A, Karch, Celeste M, Cooper, Breanna, Skorupa, Tara, Carrell, David, Norton, Joanne B, Hsu, Simon, Harari, Oscar, Cai, Yefei, Bertelsen, Sarah, Goate, Alison M, Cruchaga, Carlos
Published in Human molecular genetics (01.11.2014)
Published in Human molecular genetics (01.11.2014)
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Journal Article
Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains
Karch, Celeste M, Jeng, Amanda T, Nowotny, Petra, Cady, Janet, Cruchaga, Carlos, Goate, Alison M
Published in PloS one (30.11.2012)
Published in PloS one (30.11.2012)
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Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis
Lananna, Brian V, McKee, Celia A, King, Melvin W, Del-Aguila, Jorge L, Dimitry, Julie M, Farias, Fabiana H G, Nadarajah, Collin J, Xiong, David D, Guo, Chun, Cammack, Alexander J, Elias, Jack A, Zhang, Jinsong, Cruchaga, Carlos, Musiek, Erik S
Published in Science translational medicine (16.12.2020)
Published in Science translational medicine (16.12.2020)
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Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Schlepckow, Kai, Araque Caballero, Miguel Ángel, Franzmeier, Nicolai, Capell, Anja, Fellerer, Katrin, Nuscher, Brigitte, Eren, Erden, Levin, Johannes, Deming, Yuetiva, Piccio, Laura, Karch, Celeste M, Cruchaga, Carlos, Shaw, Leslie M, Trojanowski, John Q, Weiner, Michael, Ewers, Michael, Haass, Christian
Published in Molecular neurodegeneration (10.01.2019)
Published in Molecular neurodegeneration (10.01.2019)
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Harmonization of CSF and imaging biomarkers in Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification
Timsina, Jigyasha, Ali, Muhammad, Do, Anh, Wang, Lihua, Western, Daniel, Sung, Yun Ju, Cruchaga, Carlos
Published in Neurobiology of disease (01.01.2024)
Published in Neurobiology of disease (01.01.2024)
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Journal Article
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
Ewers, Michael, Biechele, Gloria, Suárez‐Calvet, Marc, Sacher, Christian, Blume, Tanja, Morenas‐Rodriguez, Estrella, Deming, Yuetiva, Piccio, Laura, Cruchaga, Carlos, Kleinberger, Gernot, Shaw, Leslie, Trojanowski, John Q, Herms, Jochen, Dichgans, Martin, Brendel, Matthias, Haass, Christian, Franzmeier, Nicolai
Published in EMBO molecular medicine (07.09.2020)
Published in EMBO molecular medicine (07.09.2020)
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Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging
Yan, Qi, Nho, Kwangsik, Del-Aguila, Jorge L., Wang, Xingbin, Risacher, Shannon L., Fan, Kang-Hsien, Snitz, Beth E., Aizenstein, Howard J., Mathis, Chester A., Lopez, Oscar L., Demirci, F. Yesim, Feingold, Eleanor, Klunk, William E., Saykin, Andrew J., Cruchaga, Carlos, Kamboh, M. Ilyas
Published in Molecular psychiatry (01.01.2021)
Published in Molecular psychiatry (01.01.2021)
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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Del-Aguila, Jorge L, Li, Zeran, Dube, Umber, Mihindukulasuriya, Kathie A, Budde, John P, Fernandez, Maria Victoria, Ibanez, Laura, Bradley, Joseph, Wang, Fengxian, Bergmann, Kristy, Davenport, Richard, Morris, John C, Holtzman, David M, Perrin, Richard J, Benitez, Bruno A, Dougherty, Joseph, Cruchaga, Carlos, Harari, Oscar
Published in Alzheimer's research & therapy (09.08.2019)
Published in Alzheimer's research & therapy (09.08.2019)
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Journal Article
Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline
Del-Aguila, Jorge L, Fernández, Maria Victoria, Schindler, Suzanne, Ibanez, Laura, Deming, Yuetiva, Ma, Shengmei, Saef, Ben, Black, Kathleen, Budde, John, Norton, Joanne, Chasse, Rachel, Harari, Oscar, Goate, Alison, Xiong, Chengjie, Morris, John C, Cruchaga, Carlos
Published in Journal of Alzheimer's disease (01.01.2018)
Published in Journal of Alzheimer's disease (01.01.2018)
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity
Izzo, Nicholas J, Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A, Arancio, Ottavio, Mach, Robert H, Craven, Rolf, Head, Elizabeth, LeVine, 3rd, Harry, Spires-Jones, Tara L, Catalano, Susan M
Published in PloS one (12.11.2014)
Published in PloS one (12.11.2014)
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A missense variant in SLC39A8 is associated with severe idiopathic scoliosis
Haller, Gabe, McCall, Kevin, Jenkitkasemwong, Supak, Sadler, Brooke, Antunes, Lilian, Nikolov, Momchil, Whittle, Julia, Upshaw, Zachary, Shin, Jimann, Baschal, Erin, Cruchaga, Carlos, Harms, Matthew, Raggio, Cathleen, Morcuende, Jose A., Giampietro, Philip, Miller, Nancy H., Wise, Carol, Gray, Ryan S., Solnica-Krezel, Lila, Knutson, Mitchell, Dobbs, Matthew B., Gurnett, Christina A.
Published in Nature communications (09.10.2018)
Published in Nature communications (09.10.2018)
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Journal Article
Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Bitar, Lynn, Uphaus, Timo, Thalman, Carine, Muthuraman, Muthuraman, Gyr, Luzia, Ji, Haichao, Domingues, Micaela, Endle, Heiko, Groppa, Sergiu, Steffen, Falk, Koirala, Nabin, Fan, Wei, Ibanez, Laura, Heitsch, Laura, Cruchaga, Carlos, Lee, Jin-Moo, Kloss, Florian, Bittner, Stefan, Nitsch, Robert, Zipp, Frauke, Vogt, Johannes
Published in Science translational medicine (20.04.2022)
Published in Science translational medicine (20.04.2022)
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Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes
Yang, Chengran, Fagan, Anne M, Perrin, Richard J, Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos
Published in Genome medicine (12.12.2022)
Published in Genome medicine (12.12.2022)
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Journal Article
Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan
Luo, Jingqin, Agboola, Folasade, Grant, Elizabeth, Morris, John C, Masters, Colin L, Albert, Marilyn S, Johnson, Sterling C, McDade, Eric M, Fagan, Anne M, Benzinger, Tammie L S, Hassenstab, Jason, Bateman, Randall J, Perrin, Richard J, Wang, Guoqiao, Li, Yan, Gordon, Brian, Cruchaga, Carlos, Day, Gregory S, Levin, Johannes, Vöglein, Jonathan, Ikeuchi, Takeshi, Suzuki, Kazushi, Allegri, Ricardo F, Xiong, Chengjie
Published in Brain (London, England : 1878) (19.12.2022)
Published in Brain (London, England : 1878) (19.12.2022)
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