Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity
CLADER, John W, BILLARD, William, LIU, Charles, MCCOMBIE, Stuart W, VICE, Susan, GOWEI ZHOU, GREENLEE, William J, BINCH, Herbert III, CHEN, Lian-Yong, CROSBY, Gordon JR, DUFFY, Ruth A, FORD, Jennifer, KOZLOWSKI, Joseph A, LACHOWICZ, Jean E, SHENGJIAN LI
Published in Bioorganic & medicinal chemistry (15.01.2004)
Published in Bioorganic & medicinal chemistry (15.01.2004)
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Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
KOZLOWSKI, Joseph A, LOWE, Derek B, BINCH, Herbert III, LACHOWICZ, Jean E, GUZIK, Henry S, GUOWEI ZHOU, RUPERTO, Vilma B, DUFFY, Ruth A, MCQUADE, Robert, CROSBY, Gordon JR, TAYLOR, Lisa A, BILLARD, William
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Diphenylsulfone muscarinic antagonists: Piperidine derivatives with high M2 selectivity and improved potency
BILLARD, William, BINCH, Herbert III, RUPERTO, Vilma B, TAYLOR, Lisa A, CLADER, John W, BRATZLER, Kristen, CHEN, Lian-Yong, CROSBY, Gordon JR, DUFFY, Ruth A, DUGAR, Sundeep, LACHOWICZ, Jean, MCQUADE, Robert, PUSHPAVANAM, Pradeep
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
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Design and synthesis of piperidinyl piperidine analogues as potent and selective M 2 muscarinic receptor antagonists
Wang, Yuguang, Chackalamannil, Samuel, Hu, Zhiyong, Clader, John W, Greenlee, William, Billard, William, Binch, Herbert, Crosby, Gordon, Ruperto, Vilma, Duffy, Ruth A, McQuade, Robert, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists
YUGUANG WANG, CHACKALAMANNIL, Samuel, MCQUADE, Robert, LACHOWICZ, Jean E, ZHIYONG HU, CLADER, John W, GREENLEE, William, BILLARD, William, BINCH, Herbert III, CROSBY, Gordon, RUPERTO, Vilma, DUFFY, Ruth A
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals
CAREY, Galen J, BILLARD, William, TEDESCO, Richard P, WATKINS, Robert W, COFFIN, Vicki L, BINCH, Herbert III, COHEN-WILLIAMS, Mary, CROSBY, Gordon, GRZELAK, Michael, GUZIK, Henry, KOZLOWSKI, Joseph A, LOWE, Derek B, POND, Annamarie J
Published in European journal of pharmacology (16.11.2001)
Published in European journal of pharmacology (16.11.2001)
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SCH 57790, a selective muscarinic M 2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals
Carey, Galen J., Billard, William, Binch, Herbert, Cohen-Williams, Mary, Crosby, Gordon, Grzelak, Michael, Guzik, Henry, Kozlowski, Joseph A., Lowe, Derek B., Pond, Annamarie J., Tedesco, Richard P., Watkins, Robert W., Coffin, Vicki L.
Published in European journal of pharmacology (16.11.2001)
Published in European journal of pharmacology (16.11.2001)
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Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum
Billard, W, Ruperto, V, Crosby, G, Iorio, L C, Barnett, A
Published in Life sciences (1973) (29.10.1984)
Published in Life sciences (1973) (29.10.1984)
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Facilitation of acetylcholine release and improvement in cognition by a selective M 2 muscarinic antagonist, SCH 72788
Lachowicz, Jean E., Duffy, Ruth A., Ruperto, Vilma, Kozlowski, Joseph, Zhou, Guowei, Clader, John, Billard, William, Binch, Herbert, Crosby, Gordon, Cohen-Williams, Mary, Strader, Catherine D., Coffin, Victoria
Published in Life sciences (1973) (27.04.2001)
Published in Life sciences (1973) (27.04.2001)
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Substituted 2-( R)-Methyl piperazines as muscarinic M 2 selective ligands
Kozlowski, Joseph A, Zhou, Guowei, Tagat, Jayaram R, Lin, Sue-Ing, McCombie, Stuart W, Ruperto, Vilma B, Duffy, Ruth A, McQuade, Robert A, Crosby, Gordon, Taylor, Lisa A, Billard, William, Binch, Herbert, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Improving the Oral Efficacy of CNS Drug Candidates: Discovery of Highly Orally Efficacious Piperidinyl Piperidine M2 Muscarinic Receptor Antagonists
Wang, Yuguang, Chackalamannil, Samuel, Hu, Zhiyong, Greenlee, William J, Clader, John, Boyle, Craig D, Kaminski, James J, Billard, William, Binch, Crosby, Gordon, Ruperto, Vilma, Duffy, Ruth A, Cohen-Williams, Mary, Coffin, Vicki L, Cox, Kathleen A, Grotz, Diane E, Lachowicz, Jean E
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Improving the oral efficacy of CNS drug candidates: Discovery of highly orally efficacious piperidinyl piperidine M-2 muscarinic receptor antagonists
Wang, YG, Chackalamannil, S, Hu, ZY, Greenlee, WJ, Clader, J, Boyle, CD, Kaminski, JJ, Billard, W, Binch, H, Crosby, G, Ruperto, Duffy, RA, Cohen-Williams, M, Coffin, VL, Cox, KA, Grotz, DE, Lachowicz, JE
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification
BOYLE, Craig D, VICE, Susan F, COFFIN, Vicki L, COX, Kathleen A, GROTZ, Diane E, DUFFY, Ruth A, RUPERTO, Vilma, LACHOWICZ, Jean E, CAMPION, Jennifer, CHACKALAMANNIL, Samuel, LANKIN, Claire M, MCCOMBIE, Stuart W, BILLARD, William, BINCH, Herbert III, CROSBY, Gordon, WILLIAMS, Mary-Cohen
Published in Bioorganic & medicinal chemistry letters (01.12.2002)
Published in Bioorganic & medicinal chemistry letters (01.12.2002)
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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M 2 muscarinic receptor antagonists via benzamide modification
Boyle, Craig D., Vice, Susan F., Campion, Jennifer, Chackalamannil, Samuel, Lankin, Claire M., McCombie, Stuart W., Billard, William, Binch, III, Herbert, Crosby, Gordon, Williams, Mary-Cohen, Coffin, Vicki L., Cox, Kathleen A., Grotz, Diane E., Duffy, Ruth A., Ruperto, Vilma, Lachowicz, Jean E.
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Diphenylsulfone muscarinic antagonists: piperidine derivatives with high m 2 selectivity and improved potency
Billard, William, Binch, Herbert, Bratzler, Kristen, Chen, Lian-Yong, Crosby, Gordon, Duffy, Ruth A, Dugar, Sundeep, Lachowicz, Jean, McQuade, Robert, Pushpavanam, Pradeep, Ruperto, Vilma B, Taylor, Lisa A, Clader, John W
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
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Journal Article
Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands
Kozlowski, Joseph A, Zhou, Guowei, Tagat, Jayaram R, Lin, Sue Ing, McCombie, Stuart W, Ruperto, Vilma B, Duffy, Ruth A, McQuade, Robert A, Crosby, Gordon, Taylor, Lisa A, Billard, William, Binch, Herbert, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution
BOYLE, Craig D, CHACKALAMANNIL, Samuel, YUGUANG WANG, GUOWEI ZHOU, BILLARD, William, BINCH, Herbert III, CROSBY, Gordon, COHEN-WILLIAMS, Mary, COFFIN, Vicki L, COX, Kathleen A, GROTZ, Diane E, DUFFY, Ruth A, CLADER, John W, RUPERTO, Vilma, LACHOWICZ, Jean E, GREENLEE, William J, JOSIEN, Hubert B, KAMINSKI, James J, KOZLOWSKI, Joseph A, MCCOMBIE, Stuart W, NAZARENO, Dennis V, TAGAT, Jayaram R
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Journal Article
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification
Boyle, Craig D, Vice, Susan F, Campion, Jennifer, Chackalamannil, Samuel, Lankin, Claire M, McCombie, Stuart W, Billard, William, Binch, 3rd, Herbert, Crosby, Gordon, Williams, Mary-Cohen, Coffin, Vicki L, Cox, Kathleen A, Grotz, Diane E, Duffy, Ruth A, Ruperto, Vilma, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Benzylidene ketal derivatives as M 2 muscarinic receptor antagonists
Boyle, Craig D, Chackalamannil, Samuel, Chen, Lian-Yong, Dugar, Sundeep, Pushpavanam, Pradeep, Billard, William, Binch, Herbert, Crosby, Gordon, Cohen-Williams, Mary, Coffin, Vicki L, Duffy, Ruth A, Ruperto, Vilma, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (18.12.2000)
Published in Bioorganic & medicinal chemistry letters (18.12.2000)
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