A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids
Dombach, Jamie L, Quintana, Joaquin L J, Nagy, Toni A, Wan, Chun, Crooks, Amy L, Yu, Haijia, Su, Chih-Chia, Yu, Edward W, Shen, Jingshi, Detweiler, Corrella S
Published in PLoS pathogens (01.12.2020)
Published in PLoS pathogens (01.12.2020)
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Journal Article
A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load
Reens, Abigail L, Crooks, Amy L, Su, Chih-Chia, Nagy, Toni A, Reens, David L, Podoll, Jessica D, Edwards, Madeline E, Yu, Edward W, Detweiler, Corrella S
Published in PLoS pathogens (01.06.2018)
Published in PLoS pathogens (01.06.2018)
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Journal Article
Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes
Villanueva, Joseph A, Crooks, Amy L, Nagy, Toni A, Quintana, Joaquin L J, Dalebroux, Zachary D, Detweiler, Corrella S
Published in mBio (26.10.2022)
Published in mBio (26.10.2022)
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Journal Article
Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment
Allgood, Samual C, Su, Chih-Chia, Crooks, Amy L, Meyer, Christian T, Zhou, Bojun, Betterton, Meredith D, Barbachyn, Michael R, Yu, Edward W, Detweiler, Corrella S
Published in mBio (19.12.2023)
Published in mBio (19.12.2023)
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Journal Article
Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy
Bumpers, Quinn A., Pipal, Robert W., Benz-Weeden, Anna M., Brewster, James T., Cook, Adam, Crooks, Amy L., Cruz, Cole, Dwulet, Natalie C., Gaudino, John J., Golec, Daniel, Harrison, Jacqueline A., Hartley, Dylan P., Hassanien, Sherif H., Hicken, Erik J., Kahn, Dean, Laird, Ellen R., Lemieux, Christine, Lewandowski, Nicholas, McCown, Joseph, McDonald, Matthew G., McNulty, Oren, Mou, Tung-Chung, Nguyen, Phong, Oko, Lauren, Opie, Lisa Pieti, Otten, Jennifer, Peck, Spencer C., Polites, Viktor C., Randall, Samuel D., Rosen, Rachel Z., Savechenkov, Pavel, Simpson, Helen, Singh, Anurag, Sparks, Drew, Wickersham, Kyle, Wollenberg, Lance, Wong, Christina E., Wong, Jim, Wu, Wen-I, Elsayed, Mohamed S. A., Hinklin, Ronald J., Tang, Tony P.
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice
Nagy, Toni A, Crooks, Amy L, Quintana, Joaquin L. J, Detweiler, Corrella S
Published in ACS infectious diseases (08.05.2020)
Published in ACS infectious diseases (08.05.2020)
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Journal Article
Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment
Allgood, Samual C, Su, Chih-Chia, Crooks, Amy L, Meyer, Christian T, Zhou, Bojun, Betterton, Meredith D, Barbachyn, Michael R, Yu, Edward W, Detweiler, Corrella S
Published in bioRxiv (20.09.2023)
Published in bioRxiv (20.09.2023)
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Journal Article
BACTERIAL EFFLUX PUMP INHIBITORS AND METHODS OF USE
DETWEILER, Corrella S, WONG, Christina, SUN, Xicheng, OCHSNER, Urs, CROOKS, Amy L, GRAHAM, James M
Year of Publication 12.06.2024
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Year of Publication 12.06.2024
Patent
BACTERIAL EFFLUX PUMP INHIBITORS AND METHODS OF USE
DETWEILER, Corrella S, WONG, Christina, SUN, Xicheng, OCHSNER, Urs, CROOKS, Amy L, GRAHAM, James M
Year of Publication 09.02.2023
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Year of Publication 09.02.2023
Patent
Bacterial efflux pump inhibitors and methods of use
GRAHAM, JIM, SUN, XICHENG, WONG, CHRISTINA, OCHSNER, URS, DETWEILER, CORELLA S, CROOKS, AMY L
Year of Publication 16.04.2023
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Year of Publication 16.04.2023
Patent