Therapeutic Potential of Targeting PAK Signaling
Senapedis, William, Crochiere, Marsha, Baloglu, Erkan, Landesman, Yosef
Published in Anti-cancer agents in medicinal chemistry (01.01.2016)
Published in Anti-cancer agents in medicinal chemistry (01.01.2016)
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Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis
Machlus, Kellie R., Wu, Stephen K., Vijey, Prakrith, Soussou, Thomas S., Liu, Zhi-Jian, Shacham, Eran, Unger, T.J., Kashyap, Trinayan, Klebanov, Boris, Sola-Visner, Martha, Crochiere, Marsha, Italiano, Joseph E., Landesman, Yosef
Published in Blood (31.08.2017)
Published in Blood (31.08.2017)
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Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents
Kashyap, Trinayan, Argueta, Christian, Unger, Thaddeus, Klebanov, Boris, Debler, Sophia, Senapedis, William, Crochiere, Marsha L, Lee, Margaret S, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Published in Oncotarget (20.07.2018)
Published in Oncotarget (20.07.2018)
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The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors
Farren, Matthew R, Hennessey, Rebecca C, Shakya, Reena, Elnaggar, Omar, Young, Gregory, Kendra, Kari, Landesman, Yosef, Elloul, Sivan, Crochiere, Marsha, Klebanov, Boris, Kashyap, Trinayan, Burd, Christin E, Lesinski, Gregory B
Published in Molecular cancer therapeutics (01.03.2017)
Published in Molecular cancer therapeutics (01.03.2017)
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A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds
Crochiere, Marsha L, Baloglu, Erkan, Klebanov, Boris, Donovan, Scott, Del Alamo, Diego, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Published in Oncotarget (12.01.2016)
Published in Oncotarget (12.01.2016)
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XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose
Crochiere, Marsha L, Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Published in Oncotarget (15.12.2017)
Published in Oncotarget (15.12.2017)
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Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytes
Bandyopadhyay, Amitabha, Kubilus, James K., Crochiere, Marsha L., Linsenmayer, Thomas F., Tabin, Clifford J.
Published in Developmental biology (01.09.2008)
Published in Developmental biology (01.09.2008)
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762 A first-in-human phase 1 clinical study evaluating safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the EDB+FN targeting ADC PYX-201 in participants with advanced solid tumors
Wilks, Sharon, Carneiro, Benedito, Cote, Gregory, Henry, Jason, Sen, Shiraj, Spira, Alexander I, Tsai, Frank Yung-Chin, Wang, Judy S, Crochiere, Marsha, He, Shui, Smyrnios, Sondra, Unadkat, Dipali, Zhang, Bin, Tolcher, Anthony W
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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756 First-in-human, open-label, multicenter, phase 1 clinical study to evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of anti Siglec-15 PYX-106 in subjects with advanced solid tumors
Spira, Alexander I, Gordon, Michael S, Henry, Jason, Patel, Sandip P, Sehgal, Kartik, Sen, Shiraj, Sweis, Randy, Crochiere, Marsha, He, Shui, Smyrnios, Sondra, Unadkat, Dipali, Zhang, Bin, Tolcher, Anthony W
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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369 Clinical update of VT1021, a first-in-class CD36 and CD47 targeting immunomodulating agent, in subjects with pancreatic cancer and other solid tumors stratified by novel biomarkers
Mahalingam, Devalingam, Mulcahy, Mary, Juric, Dejan, Patel, Manish, Pant, Shubham, Ulahannan, Susanna, Dowlati, Afshin, Bullock, Andrea, Vaickus, Lou, Fyfe, Susanne, Vincent, Melanie, Wang, Suming, Chen, Jian, Crochiere, Marsha, Watnick, Randolph, Cieslewicz, Michael, Watnick, Jing
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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374 A first-in-human Phase 1/2 open label trial evaluating the safety, pharmacology, and preliminary efficacy of VT1021 in subjects with advanced solid tumors
Mahalingam, Devalingam, Harb, Wael, Patnaik, Amita, Ulahannan, Susanna, Mahdi, Haider, Ahluwalia, Manmeet, Patel, Manish, Dowlati, Afshin, Bullock, Andrea, Wen, Patrick, Pant, Shubham, Mulcahy, Mary, Guttendorf, Robert, Vaickus, Lou, Wang, Suming, Crochiere, Marsha, Vincent, Melanie, Cieslewicz, Michael, Watnick, Jing
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing
Neggers, Jasper E., Vercruysse, Thomas, Jacquemyn, Maarten, Vanstreels, Els, Baloglu, Erkan, Shacham, Sharon, Crochiere, Marsha, Landesman, Yosef, Daelemans, Dirk
Published in Chemistry & biology (22.01.2015)
Published in Chemistry & biology (22.01.2015)
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A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth
Rane, Chetan, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Crochiere, Marsha, Das-Gupta, Soumyasri, Minden, Audrey
Published in Scientific reports (15.02.2017)
Published in Scientific reports (15.02.2017)
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Multiple mechanisms of perichondrial regulation of cartilage growth
Di Nino, Dana L., Crochiere, Marsha L., Linsenmayer, Thomas F.
Published in Developmental dynamics (01.11.2002)
Published in Developmental dynamics (01.11.2002)
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Cloning and Mitochondrial Localization of Full-Length D-AKAP2, a Protein Kinase A Anchoring Protein
Wang, Lin, Sunahara, Roger K., Krumins, Andrejs, Perkins, Guy, Crochiere, Marsha L., Mackey, Mason, Bell, Sean, Ellisman, Mark H., Taylor, Susan S.
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2001)
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Abstract LB-B09: Application of Fluorescence Correlation Spectroscopy as a novel tool to quantify target occupancy in cells and tumor tissue
Becker, Frank, Hansen, Kerrin, Crochiere, Marsha, Landesmann, Yosef, Hannus, Stefan
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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