A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
Albulescu, Laura-Oana, Xie, Chunfang, Ainsworth, Stuart, Alsolaiss, Jaffer, Crittenden, Edouard, Dawson, Charlotte A, Softley, Rowan, Bartlett, Keirah E, Harrison, Robert A, Kool, Jeroen, Casewell, Nicholas R
Published in Nature communications (15.12.2020)
Published in Nature communications (15.12.2020)
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Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
Albulescu, Laura-Oana, Xie, Chunfang, Ainsworth, Stuart, Alsolaiss, Jaffer, Crittenden, Edouard, Dawson, Charlotte A., Softley, Rowan, Bartlett, Keirah E., Harrison, Robert A., Kool, Jeroen, Casewell, Nicholas R.
Published in Nature communications (24.06.2021)
Published in Nature communications (24.06.2021)
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Proteomics and histological assessment of an organotypic model of human skin following exposure to Naja nigricollis venom
Ahmadi, Shirin, Pachis, Spyridon T., Kalogeropoulos, Konstantinos, McGeoghan, Farrell, Canbay, Vahap, Hall, Steven R., Crittenden, Edouard P., Dawson, Charlotte A., Bartlett, Keirah E., Gutiérrez, José María, Casewell, Nicholas R., Keller, Ulrich auf dem, Laustsen, Andreas H.
Published in Toxicon (Oxford) (01.12.2022)
Published in Toxicon (Oxford) (01.12.2022)
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Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms
Alomran, Nessrin, Alsolaiss, Jaffer, Albulescu, Laura-Oana, Crittenden, Edouard, Harrison, Robert A, Ainsworth, Stuart, Casewell, Nicholas R
Published in PLoS neglected tropical diseases (02.06.2022)
Published in PLoS neglected tropical diseases (02.06.2022)
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Journal Article
Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms
Alomran, Nessrin, Alsolaiss, Jaffer, Albulescu, Laura-Oana, Crittenden, Edouard, Harrison, Robert A, Ainsworth, Stuart, Casewell, Nicholas R
Published in PLoS neglected tropical diseases (01.08.2021)
Published in PLoS neglected tropical diseases (01.08.2021)
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Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL
Laprade, William, Bartlett, Keirah E, Christensen, Charlotte R, Kazandjian, Taline D, Patel, Rohit N, Crittenden, Edouard, Dawson, Charlotte A, Mansourvar, Marjan, Wolff, Darian S, Fryer, Thomas, Laustsen, Andreas H, Casewell, Nicholas R, Gutiérrez, José María, Hall, Steven R, Jenkins, Timothy P
Published in Scientific reports (08.12.2023)
Published in Scientific reports (08.12.2023)
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Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition
Menzies, Stefanie K, Dawson, Charlotte A, Crittenden, Edouard, Edge, Rebecca J, Hall, Steven R, Alsolaiss, Jaffer, Wilkinson, Mark C, Casewell, Nicholas R, Harrison, Robert A, Ainsworth, Stuart
Published in Scientific reports (05.07.2022)
Published in Scientific reports (05.07.2022)
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Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing
Menzies, Stefanie K, Litschka-Koen, Thea, Edge, Rebecca J, Alsolaiss, Jaffer, Crittenden, Edouard, Hall, Steven R, Westhorpe, Adam, Thomas, Brent, Murray, James, Shongwe, Nondusimo, Padidar, Sara, Lalloo, David G, Casewell, Nicholas R, Pons, Jonathan, Harrison, Robert A
Published in PLoS neglected tropical diseases (01.09.2022)
Published in PLoS neglected tropical diseases (01.09.2022)
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Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms
Alomran, Nessrin, Blundell, Patricia, Alsolaiss, Jaffer, Crittenden, Edouard, Ainsworth, Stuart, Dawson, Charlotte A, Edge, Rebecca J, Hall, Steven R, Harrison, Robert A, Wilkinson, Mark C, Menzies, Stefanie K, Casewell, Nicholas R
Published in Toxins (29.06.2022)
Published in Toxins (29.06.2022)
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In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus
Menzies, Stefanie K., Clare, Rachel H., Xie, Chunfang, Westhorpe, Adam, Hall, Steven R., Edge, Rebecca J., Alsolaiss, Jaffer, Crittenden, Edouard, Marriott, Amy E., Harrison, Robert A., Kool, Jeroen, Casewell, Nicholas R.
Published in Toxicon X (01.06.2022)
Published in Toxicon X (01.06.2022)
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Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite
Albulescu, Laura-Oana, Hale, Melissa S, Ainsworth, Stuart, Alsolaiss, Jaffer, Crittenden, Edouard, Calvete, Juan J, Evans, Chloe, Wilkinson, Mark C, Harrison, Robert A, Kool, Jeroen, Casewell, Nicholas R
Published in Science translational medicine (06.05.2020)
Published in Science translational medicine (06.05.2020)
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Journal Article
Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms
Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A. Harrison, Stuart Ainsworth, Nicholas R. Casewell
Published in PLoS neglected tropical diseases (01.06.2022)
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Published in PLoS neglected tropical diseases (01.06.2022)
Journal Article
Unexpected lack of specialisation in the flow properties of spitting cobra venom
Avella, Ignazio, Barajas-Ledesma, Edgar, Casewell, Nicholas R, Harrison, Robert A, Rowley, Paul D, Crittenden, Edouard, Wüster, Wolfgang, Castiglia, Riccardo, Holland, Chris, van der Meijden, Arie
Published in Journal of experimental biology (01.04.2021)
Published in Journal of experimental biology (01.04.2021)
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Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming
Du, Tian Y, Hall, Steven R, Chung, Felicity, Kurdyukov, Sergey, Crittenden, Edouard, Patel, Karishma, Dawson, Charlotte A, Westhorpe, Adam P, Bartlett, Keirah E, Rasmussen, Sean A, Moreno, Cesar L, Denes, Christopher E, Albulescu, Laura-Oana, Marriott, Amy E, Mackay, Joel P, Wilkinson, Mark C, Gutiérrez, José María, Casewell, Nicholas R, Neely, G Gregory
Published in Science translational medicine (17.07.2024)
Published in Science translational medicine (17.07.2024)
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De novo designed proteins neutralize lethal snake venom toxins
Baker, David, Torres, Susana Vazquez, Valle, Melisa Benard, Mackessy, Stephen, Menzies, Stefanie, Casewell, Nicholas, Ahmadi, Shirin, Burlet, Nick, Muratspahić, Edin, Sappington, Isaac, Overath, Max, Rivera-de-Torre, Esperanza, Ledergerber, Jann, Laustsen, Andreas Hougaard, Boddum, Kim, Bera, Asim, Kang, Alex, Brackenbrough, Evans, Cardoso, Iara, Crittenden, Edouard, Edge, Rebecca, Decarreau, Justin, Ragotte, Robert, Pillai, Arvind, Abedi, Mohamad, Han, Hannah, Gerben, Stacey, Murray, Analisa, Skotheim, Rebecca, Stuart, Lynda, Stewart, Lance, Fryer, Thomas, Jenkins, Timothy
Published in Research square (17.05.2024)
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Published in Research square (17.05.2024)
Journal Article
Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing
Menzies, Stefanie K, Litschka-Koen, Thea, Edge, Rebecca J, Jaffer Alsolaiss, Crittenden, Edouard, Hall, Steven R, Westhorpe, Adam, Thomas, Brent, Murray, James, Shongwe, Nondusimo, Padidar, Sara, Lalloo, David G, Casewell, Nicholas R, Pons, Jonathan, Harrison, Robert A
Published in bioRxiv (18.05.2022)
Published in bioRxiv (18.05.2022)
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Paper
Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms
Alomran, Nessrin, Blundell, Patricia, Jaffer Alsolaiss, Crittenden, Edouard, Ainsworth, Stuart, Dawson, Charlotte A, Edge, Rebecca J, Hall, Steven R, Harrison, Robert A, Wilkinson, Mark C, Menzies, Stefanie K, Casewell, Nicholas R
Published in bioRxiv (08.05.2022)
Published in bioRxiv (08.05.2022)
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Paper
A combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite
Laura-Oana Albulescu, Xie, Chunfang, Ainsworth, Stuart, Jaffer Alsolaiss, Crittenden, Edouard, Dawson, Charlotte A, Softley, Rowan, Bartlett, Keirah E, Harrison, Robert A, Kool, Jeroen, Casewell, Nicholas R
Published in bioRxiv (15.05.2020)
Published in bioRxiv (15.05.2020)
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Paper
Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite
Laura-Oana Albulescu, Hale, Melissa, Ainsworth, Stuart, Jaffer Alsolaiss, Crittenden, Edouard, Calvete, Juan J, Wilkinson, Mark C, Harrison, Robert A, Kool, Jeroen, Casewell, Nicholas R
Published in bioRxiv (28.07.2019)
Published in bioRxiv (28.07.2019)
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