Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease
Cristóvão, Joana S., Gomes, Cláudio M., Santos, Renata
Published in Oxidative medicine and cellular longevity (01.01.2016)
Published in Oxidative medicine and cellular longevity (01.01.2016)
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Distribution and Relative Abundance of S100 Proteins in the Brain of the APP23 Alzheimer's Disease Model Mice
Hagmeyer, Simone, Romão, Mariana A, Cristóvão, Joana S, Vilella, Antonietta, Zoli, Michele, Gomes, Cláudio M, Grabrucker, Andreas M
Published in Frontiers in neuroscience (20.06.2019)
Published in Frontiers in neuroscience (20.06.2019)
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The S100B Alarmin Is a Dual-Function Chaperone Suppressing Amyloid‑β Oligomerization through Combined Zinc Chelation and Inhibition of Protein Aggregation
Cristóvão, Joana S, Figueira, António J, Carapeto, Ana P, Rodrigues, Mário S, Cardoso, Isabel, Gomes, Cláudio M
Published in ACS chemical neuroscience (02.09.2020)
Published in ACS chemical neuroscience (02.09.2020)
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Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain
Hagmeyer, Simone, Cristóvão, Joana S, Mulvihill, John J E, Boeckers, Tobias M, Gomes, Cláudio M, Grabrucker, Andreas M
Published in Frontiers in molecular neuroscience (17.01.2018)
Published in Frontiers in molecular neuroscience (17.01.2018)
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Journal Article
Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1)
Estácio, Sílvia G., Leal, Sónia S., Cristóvão, Joana S., Faísca, Patrícia F.N., Gomes, Cláudio M.
Published in Biochimica et biophysica acta (01.02.2015)
Published in Biochimica et biophysica acta (01.02.2015)
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Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
Moreira, Guilherme G., Cantrelle, François-Xavier, Quezada, Andrea, Carvalho, Filipa S., Cristóvão, Joana S., Sengupta, Urmi, Puangmalai, Nicha, Carapeto, Ana P., Rodrigues, Mário S., Cardoso, Isabel, Fritz, Güenter, Herrera, Federico, Kayed, Rakez, Landrieu, Isabelle, Gomes, Cláudio M.
Published in Nature communications (01.11.2021)
Published in Nature communications (01.11.2021)
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Cu2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation
Cristóvão, Joana S, Moreira, Guilherme G, Rodrigues, Filipe E P, Carapeto, Ana P, Rodrigues, Mário S, Cardoso, Isabel, Ferreira, António E N, Machuqueiro, Miguel, Fritz, Guenter, Gomes, Cláudio M
Published in Chemical communications (Cambridge, England) (14.01.2021)
Published in Chemical communications (Cambridge, England) (14.01.2021)
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Journal Article
Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution
Moreira, Guilherme G, Cristóvão, Joana S, Torres, Vukosava M, Carapeto, Ana P, Rodrigues, Mário S, Landrieu, Isabelle, Cordeiro, Carlos, Gomes, Cláudio M
Published in International journal of molecular sciences (27.11.2019)
Published in International journal of molecular sciences (27.11.2019)
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Cu-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation
Cristóvão, Joana S, Moreira, Guilherme G, Rodrigues, Filipe E. P, Carapeto, Ana P, Rodrigues, Mário S, Cardoso, Isabel, Ferreira, António E. N, Machuqueiro, Miguel, Fritz, Guenter, Gomes, Cláudio M
Published in Chemical communications (Cambridge, England) (14.01.2021)
Published in Chemical communications (Cambridge, England) (14.01.2021)
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Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer’s Disease
de Matos, Ana M, Blázquez-Sánchez, M. Teresa, Bento-Oliveira, Andreia, de Almeida, Rodrigo F. M, Nunes, Rafael, Lopes, Pedro E. M, Machuqueiro, Miguel, Cristóvão, Joana S, Gomes, Cláudio M, Souza, Cleide S, El Idrissi, Imane G, Colabufo, Nicola A, Diniz, Ana, Marcelo, Filipa, Oliveira, M. Conceição, López, Óscar, Fernandez-Bolaños, José G, Dätwyler, Philipp, Ernst, Beat, Ning, Ke, Garwood, Claire, Chen, Beining, Rauter, Amélia P
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Cu 2+ -binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation
Cristóvão, Joana S, Moreira, Guilherme G, Rodrigues, Filipe E P, Carapeto, Ana P, Rodrigues, Mário S, Cardoso, Isabel, Ferreira, António E N, Machuqueiro, Miguel, Fritz, Guenter, Gomes, Cláudio M
Published in Chemical communications (Cambridge, England) (14.01.2021)
Published in Chemical communications (Cambridge, England) (14.01.2021)
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Journal Article
S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis
Daini, Eleonora, Hagmeyer, Simone, De Benedictis, Chiara A, Cristóvão, Joana S, Bodria, Martina, Ross, Aisling M, Raab, Andrea, Boeckers, Tobias M, Feldmann, Joerg, Gomes, Cláudio M, Zoli, Michele, Vilella, Antonietta, Grabrucker, Andreas M
Published in Translational psychiatry (05.11.2021)
Published in Translational psychiatry (05.11.2021)
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M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue
Martins, Ivone M, Lima, Alexandre, de Graaff, Wim, Cristóvão, Joana S, Brosens, Niek, Aronica, Eleonora, Kluskens, Leon D, Gomes, Cláudio M, Azeredo, Joana, Kessels, Helmut W
Published in Communications biology (27.01.2024)
Published in Communications biology (27.01.2024)
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