Subclonal reconstruction of tumors by using machine learning and population genetics
Caravagna, Giulio, Heide, Timon, Williams, Marc J., Zapata, Luis, Nichol, Daniel, Chkhaidze, Ketevan, Cross, William, Cresswell, George D., Werner, Benjamin, Acar, Ahmet, Chesler, Louis, Barnes, Chris P., Sanguinetti, Guido, Graham, Trevor A., Sottoriva, Andrea
Published in Nature genetics (01.09.2020)
Published in Nature genetics (01.09.2020)
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Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
Acar, Ahmet, Nichol, Daniel, Fernandez-Mateos, Javier, Cresswell, George D., Barozzi, Iros, Hong, Sung Pil, Trahearn, Nicholas, Spiteri, Inmaculada, Stubbs, Mark, Burke, Rosemary, Stewart, Adam, Caravagna, Giulio, Werner, Benjamin, Vlachogiannis, Georgios, Maley, Carlo C., Magnani, Luca, Valeri, Nicola, Banerji, Udai, Sottoriva, Andrea
Published in Nature communications (21.04.2020)
Published in Nature communications (21.04.2020)
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Journal Article
Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
Cresswell, George D., Nichol, Daniel, Spiteri, Inmaculada, Tari, Haider, Zapata, Luis, Heide, Timon, Maley, Carlo C., Magnani, Luca, Schiavon, Gaia, Ashworth, Alan, Barry, Peter, Sottoriva, Andrea
Published in Nature communications (27.03.2020)
Published in Nature communications (27.03.2020)
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Journal Article
Measuring single cell divisions in human tissues from multi-region sequencing data
Werner, Benjamin, Case, Jack, Williams, Marc J., Chkhaidze, Ketevan, Temko, Daniel, Fernández-Mateos, Javier, Cresswell, George D., Nichol, Daniel, Cross, William, Spiteri, Inmaculada, Huang, Weini, Tomlinson, Ian P. M., Barnes, Chris P., Graham, Trevor A., Sottoriva, Andrea
Published in Nature communications (25.02.2020)
Published in Nature communications (25.02.2020)
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Journal Article
The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer
Barry, Peter, Vatsiou, Alexandra, Spiteri, Inmaculada, Nichol, Daniel, Cresswell, George D, Acar, Ahmet, Trahearn, Nicholas, Hrebien, Sarah, Garcia-Murillas, Isaac, Chkhaidze, Kate, Ermini, Luca, Huntingford, Ian Said, Cottom, Hannah, Zabaglo, Lila, Koelble, Konrad, Khalique, Saira, Rusby, Jennifer E, Muscara, Francesca, Dowsett, Mitch, Maley, Carlo C, Natrajan, Rachael, Yuan, Yinyin, Schiavon, Gaia, Turner, Nicholas, Sottoriva, Andrea
Published in Clinical cancer research (01.10.2018)
Published in Clinical cancer research (01.10.2018)
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Journal Article
Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors
Treger, Taryn D., Chagtai, Tasnim, Butcher, Robert, Cresswell, George D., Al-Saadi, Reem, Brok, Jesper, Williams, Richard D., Roberts, Chrissy, Luscombe, Nicholas M., Pritchard Jones, Kathy, Mifsud, William
Published in Translational oncology (01.12.2018)
Published in Translational oncology (01.12.2018)
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Journal Article
Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications
Cresswell, George D., Apps, John R., Chagtai, Tasnim, Mifsud, Borbala, Bentley, Christopher C., Maschietto, Mariana, Popov, Sergey D., Weeks, Mark E., Olsen, Øystein E., Sebire, Neil J., Pritchard-Jones, Kathy, Luscombe, Nicholas M., Williams, Richard D., Mifsud, William
Published in EBioMedicine (01.07.2016)
Published in EBioMedicine (01.07.2016)
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Journal Article
Pervasive chromosomal instability and karyotype order in tumour evolution
Watkins, Thomas B. K., Lim, Emilia L., Petkovic, Marina, Elizalde, Sergi, Birkbak, Nicolai J., Wilson, Gareth A., Moore, David A., Grönroos, Eva, Rowan, Andrew, Dewhurst, Sally M., Demeulemeester, Jonas, Dentro, Stefan C., Horswell, Stuart, Au, Lewis, Haase, Kerstin, Escudero, Mickael, Rosenthal, Rachel, Bakir, Maise Al, Xu, Hang, Litchfield, Kevin, Lu, Wei Ting, Mourikis, Thanos P., Dietzen, Michelle, Spain, Lavinia, Cresswell, George D., Biswas, Dhruva, Lamy, Philippe, Nordentoft, Iver, Harbst, Katja, Castro-Giner, Francesc, Yates, Lucy R., Caramia, Franco, Jaulin, Fanny, Vicier, Cécile, Tomlinson, Ian P. M., Brastianos, Priscilla K., Cho, Raymond J., Bastian, Boris C., Dyrskjøt, Lars, Jönsson, Göran B., Savas, Peter, Loi, Sherene, Campbell, Peter J., Andre, Fabrice, Luscombe, Nicholas M., Steeghs, Neeltje, Tjan-Heijnen, Vivianne C. G., Szallasi, Zoltan, Turajlic, Samra, Jamal-Hanjani, Mariam, Van Loo, Peter, Bakhoum, Samuel F., Schwarz, Roland F., McGranahan, Nicholas, Swanton, Charles
Published in Nature (London) (05.11.2020)
Published in Nature (London) (05.11.2020)
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Journal Article
The co-evolution of the genome and epigenome in colorectal cancer
Heide, Timon, Househam, Jacob, Cresswell, George D., Spiteri, Inmaculada, Lynn, Claire, Mossner, Maximilian, Kimberley, Chris, Fernandez-Mateos, Javier, Chen, Bingjie, Zapata, Luis, James, Chela, Barozzi, Iros, Chkhaidze, Ketevan, Nichol, Daniel, Gunasri, Vinaya, Berner, Alison, Schmidt, Melissa, Lakatos, Eszter, Baker, Ann-Marie, Costa, Helena, Mitchinson, Miriam, Piazza, Rocco, Jansen, Marnix, Caravagna, Giulio, Ramazzotti, Daniele, Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Graham, Trevor A., Sottoriva, Andrea
Published in Nature (London) (24.11.2022)
Published in Nature (London) (24.11.2022)
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Journal Article
Phenotypic plasticity and genetic control in colorectal cancer evolution
Househam, Jacob, Heide, Timon, Cresswell, George D., Spiteri, Inmaculada, Kimberley, Chris, Zapata, Luis, Lynn, Claire, James, Chela, Mossner, Maximilian, Fernandez-Mateos, Javier, Vinceti, Alessandro, Baker, Ann-Marie, Gabbutt, Calum, Berner, Alison, Schmidt, Melissa, Chen, Bingjie, Lakatos, Eszter, Gunasri, Vinaya, Nichol, Daniel, Costa, Helena, Mitchinson, Miriam, Ramazzotti, Daniele, Werner, Benjamin, Iorio, Francesco, Jansen, Marnix, Caravagna, Giulio, Barnes, Chris P., Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Sottoriva, Andrea, Graham, Trevor A.
Published in Nature (London) (24.11.2022)
Published in Nature (London) (24.11.2022)
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Journal Article
Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Rosano, Dalia, Sofyali, Emre, Dhiman, Heena, Ghirardi, Chiara, Ivanoiu, Diana, Heide, Timon, Vingiani, Andrea, Bertolotti, Alessia, Pruneri, Giancarlo, Canale, Eleonora, Dewhurst, Hannah F, Saha, Debjani, Slaven, Neil, Barozzi, Iros, Li, Tong, Zemlyanskiy, Grigory, Phillips, Henry, James, Chela, Győrffy, Balázs, Lynn, Claire, Cresswell, George D, Rehman, Farah, Noberini, Roberta, Bonaldi, Tiziana, Sottoriva, Andrea, Magnani, Luca
Published in Cancer discovery (01.05.2024)
Published in Cancer discovery (01.05.2024)
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EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers
Smyth, Elizabeth C, Vlachogiannis, Georgios, Hedayat, Somaieh, Harbery, Alice, Hulkki-Wilson, Sanna, Salati, Massimiliano, Kouvelakis, Kyriakos, Fernandez-Mateos, Javier, Cresswell, George D, Fontana, Elisa, Seidlitz, Therese, Peckitt, Clare, Hahne, Jens C, Lampis, Andrea, Begum, Ruwaida, Watkins, David, Rao, Sheela, Starling, Naureen, Waddell, Tom, Okines, Alicia, Crosby, Tom, Mansoor, Was, Wadsley, Jonathan, Middleton, Gary, Fassan, Matteo, Wotherspoon, Andrew, Braconi, Chiara, Chau, Ian, Vivanco, Igor, Sottoriva, Andrea, Stange, Daniel E, Cunningham, David, Valeri, Nicola
Published in Gut (01.09.2021)
Published in Gut (01.09.2021)
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A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations
Saldana-Guerrero, Ingrid M., Montano-Gutierrez, Luis F., Boswell, Katy, Hafemeister, Christoph, Poon, Evon, Shaw, Lisa E., Stavish, Dylan, Lea, Rebecca A., Wernig-Zorc, Sara, Bozsaky, Eva, Fetahu, Irfete S., Zoescher, Peter, Pötschger, Ulrike, Bernkopf, Marie, Wenninger-Weinzierl, Andrea, Sturtzel, Caterina, Souilhol, Celine, Tarelli, Sophia, Shoeb, Mohamed R., Bozatzi, Polyxeni, Rados, Magdalena, Guarini, Maria, Buri, Michelle C., Weninger, Wolfgang, Putz, Eva M., Huang, Miller, Ladenstein, Ruth, Andrews, Peter W., Barbaric, Ivana, Cresswell, George D., Bryant, Helen E., Distel, Martin, Chesler, Louis, Taschner-Mandl, Sabine, Farlik, Matthias, Tsakiridis, Anestis, Halbritter, Florian
Published in Nature communications (03.05.2024)
Published in Nature communications (03.05.2024)
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Journal Article
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Fernandez-Mateos, Javier, Cresswell, George D, Trahearn, Nicholas, Webb, Katharine, Sakr, Chirine, Lampis, Andrea, Stuttle, Christine, Corbishley, Catherine M, Stavrinides, Vasilis, Zapata, Luis, Spiteri, Inmaculada, Heide, Timon, Gallagher, Lewis, James, Chela, Ramazzotti, Daniele, Gao, Annie, Kote-Jarai, Zsofia, Acar, Ahmet, Truelove, Lesley, Proszek, Paula, Murray, Julia, Reid, Alison, Wilkins, Anna, Hubank, Michael, Eeles, Ros, Dearnaley, David, Sottoriva, Andrea
Published in Nature cancer (01.09.2024)
Published in Nature cancer (01.09.2024)
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O47 Spatially resolving the dynamics of immune escape in advanced colorectal cancer
Gunasri, Vinaya, Lakatos, Eszter, Trahearn, Nick, Cisneros, Luis, Househam, Jacob, Heide, Timon, Cresswell, George D, Spiteri, Inmaculada, Mossner, Maximilian, Kimberley, Christopher, Luis Zapata Ortiz, Jansen, Marnix, Caravagna, Giulio, Rodriguez-Justo, Manuel, Shibata, Darryl, Bridgewater, John, Consortium, EPICC, Baker, Ann-Marie, Sottoriva, Andrea, Graham, Trevor
Published in Gut (01.06.2023)
Published in Gut (01.06.2023)
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Journal Article
253e IMMUNE EDITING IN THE INVASIVE MARGIN AND NODE DEPOSITS OF COLORECTAL CANCER SELECTS FOR CELLULAR NEIGHBOURHOODS ENRICHED IN PDL1+ CANCER CELLS
Gunasri, Vinaya, Lakatos, Eszter, Trahearn, Nick, Cisneros, Luis, Househam, Jacob, Heide, Timon, Cresswell, George D., Spiteri, Inmaculada, Mossner, Maximilian, Kimberley, Christopher, Ortiz, Luis Zapata, James, Chela, Lynn, Claire, Berner, Alison A., Costa, Helena, Mitchison, Miriam, Jansen, Marnix, Caravagna, Giulio, Rodriguez-Justo, Manuel, Shibata, Darryl, Bridgewater, John, Baker, Ann-Marie, Sottoriva, Andrea, Graham, Trevor A.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
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Journal Article
The spatio-temporal evolution of lymph node spread in early breast cancer
Barry, Peter, Vatsiou, Alexandra, Spiteri, Inmaculada, Nichol, Daniel, Cresswell, George D., Acar, Ahmet, Trahearn, Nicholas, Hrebien, Sarah, Garcia-Murillas, Isaac, Chkhaidze, Kate, Ermini, Luca, Huntingford, Ian Said, Cottom, Hannah, Zabaglo, Lila, Koelble, Konrad, Khalique, Saira, Rusby, Jennifer, Muscara, Francesca, Dowsett, Mitch, Maley, Carlo, Natrajan, Rachael, Yuan, Yinyin, Schiavon, Gaia, Turner, Nicholas, Sottoriva, Andrea
Published in Clinical cancer research (11.06.2018)
Published in Clinical cancer research (11.06.2018)
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Journal Article
Abstract A045: Multiple roles for plasticity in metastasis and therapy resistance in long-term survivors of metastatic colorectal cancer
Berner, Alison May, Gabbutt, Calum, Nowinski, Salpie, Househam, Jacob, Trahearn, Nick, Cresswell, George D., Nadhamuni, Vinaya Srirangam, Kimberley, Christopher, Fassan, Matteo, Baker, Ann-Marie, Sottoriva, Andrea, Thirlwell, Christina, Bridgewater, John, Graham, Trevor
Published in Cancer research (Chicago, Ill.) (15.05.2022)
Published in Cancer research (Chicago, Ill.) (15.05.2022)
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Journal Article
Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors12
Treger, Taryn D., Chagtai, Tasnim, Butcher, Robert, Cresswell, George D., Al-Saadi, Reem, Brok, Jesper, Williams, Richard D., Roberts, Chrissy, Luscombe, Nicholas M., Pritchard Jones, Kathy, Mifsud, William
Published in Translational oncology (29.08.2018)
Published in Translational oncology (29.08.2018)
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Journal Article
Low coverage whole genome sequencing of low-grade dysplasia strongly predicts colorectal cancer risk in ulcerative colitis
Al Bakir, Ibrahim, Curtius, Kit, Cresswell, George D, Grant, Heather E, Nasreddin, Nadia, Smith, Kane, Nowinski, Salpie, Guo, Qingli, Belnoue-Davis, Hayley L, Fisher, Jennifer, Clarke, Theo, Kimberley, Christopher, Mossner, Maximilian, Dunne, Philip D, Loughrey, Maurice B, Speight, Ally, East, James E, Wright, Nicholas A, Rodriguez-Justo, Manuel, Jansen, Marnix, Moorghen, Morgan, Baker, Ann-Marie, Leedham, Simon J, Hart, Ailsa L, Graham, Trevor A
Published in medRxiv : the preprint server for health sciences (08.07.2024)
Published in medRxiv : the preprint server for health sciences (08.07.2024)
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