Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
Brouwers, Bas, de Faudeur, Geoffroy, Osipovich, Anna B., Goyvaerts, Lotte, Lemaire, Katleen, Boesmans, Leen, Cauwelier, Elisa J.G., Granvik, Mikaela, Pruniau, Vincent P.E.G., Van Lommel, Leentje, Van Schoors, Jolien, Stancill, Jennifer S., Smolders, Ilse, Goffin, Vincent, Binart, Nadine, in’t Veld, Peter, Declercq, Jeroen, Magnuson, Mark A., Creemers, John W.M., Schuit, Frans, Schraenen, Anica
Published in Cell metabolism (02.12.2014)
Published in Cell metabolism (02.12.2014)
Get full text
Journal Article
Proprotein convertases in human atherosclerotic plaques: The overexpression of FURIN and its substrate cytokines BAFF and APRIL
Turpeinen, Hannu, Raitoharju, Emma, Oksanen, Anna, Oksala, Niku, Levula, Mari, Lyytikäinen, Leo-Pekka, Järvinen, Otso, Creemers, John W.M, Kähönen, Mika, Laaksonen, Reijo, Pelto-Huikko, Markku, Lehtimäki, Terho, Pesu, Marko
Published in Atherosclerosis (01.12.2011)
Published in Atherosclerosis (01.12.2011)
Get full text
Journal Article
Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice
Nuytens, Kim, Gantois, Ilse, Stijnen, Pieter, Iscru, Emilia, Laeremans, Annelies, Serneels, Lutgarde, Van Eylen, Lien, Liebhaber, Stephen A, Devriendt, Koen, Balschun, Detlef, Arckens, Lutgarde, Creemers, John W.M, D'Hooge, Rudi
Published in Neurobiology of disease (01.03.2013)
Published in Neurobiology of disease (01.03.2013)
Get full text
Journal Article
Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism
Löffler, Dennis, Behrendt, Susanne, Creemers, John W.M, Klammt, Jürgen, Aust, Gabriela, Stanik, Juraj, Kiess, Wieland, Kovacs, Peter, Körner, Antje
Published in Molecular metabolism (Germany) (01.03.2017)
Published in Molecular metabolism (Germany) (01.03.2017)
Get full text
Journal Article
PREPL, a prolyl endopeptidase-like enzyme by name only?--Lessons from patients
Boonen, Kurt, Régal, Luc, Jaeken, Jaak, Creemers, John W M
Published in CNS & neurological disorders drug targets (01.05.2011)
Published in CNS & neurological disorders drug targets (01.05.2011)
Get more information
Journal Article
Proprotein convertase furin regulates osteocalcin and bone endocrine function
Al Rifai, Omar, Chow, Jacqueline, Lacombe, Julie, Julien, Catherine, Faubert, Denis, Susan-Resiga, Delia, Essalmani, Rachid, Creemers, John Wm, Seidah, Nabil G, Ferron, Mathieu
Published in The Journal of clinical investigation (01.11.2017)
Published in The Journal of clinical investigation (01.11.2017)
Get full text
Journal Article
PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome
Régal, Luc, Shen, Xin-Ming, Selcen, Duygu, Verhille, Chantal, Meulemans, Sandra, Creemers, John W M, Engel, Andrew G
Published in Neurology (08.04.2014)
Published in Neurology (08.04.2014)
Get more information
Journal Article
PREPL deficiency: delineation of the phenotype and development of a functional blood assay
Régal, Luc, Mårtensson, Emma, Maystadt, Isabelle, Voermans, Nicol, Lederer, Damien, Burlina, Alberto, Juan Fita, María Jesús, Hoogeboom, A. Jeannette M., Olsson Engman, Mia, Hollemans, Tess, Schouten, Meyke, Meulemans, Sandra, Jonson, Tord, François, Inge, Gil Ortega, David, Kamsteeg, Erik-Jan, Creemers, John W.M.
Published in Genetics in medicine (01.01.2018)
Published in Genetics in medicine (01.01.2018)
Get full text
Journal Article
Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice
Coppola, Ilaria, Brouwers, Bas, Walker, Leanne, Alar, Ceyhun, Meulemans, Sandra, White, Anne, Ramos-Molina, Bruno, Creemers, John W.M.
Published in Molecular metabolism (Germany) (01.12.2022)
Published in Molecular metabolism (Germany) (01.12.2022)
Get full text
Journal Article
Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines
Declercq, Jeroen, Ramos-Molina, Bruno, Sannerud, Ragna, Brouwers, Bas, Pruniau, Vincent P.E.G., Meulemans, Sandra, Plets, Evelyn, Annaert, Wim, Creemers, John W.M.
Published in European journal of cell biology (01.08.2017)
Published in European journal of cell biology (01.08.2017)
Get full text
Journal Article
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
Jackson, Robert S, Creemers, John W M, Farooqi, I Sadaf, Raffin-Sanson, Marie-Laure, Varro, Andrea, Dockray, Graham J, Holst, Jens J, Brubaker, Patricia L, Corvol, Pierre, Polonsky, Kenneth S, Ostrega, Diane, Becker, Kenneth L, Bertagna, Xavier, Hutton, John C, White, Anne, Dattani, Mehul T, Hussain, Khalid, Middleton, Stephen J, Nicole, Thomasina M, Milla, Peter J, Lindley, Keith J, O'Rahilly, Stephen
Published in The Journal of clinical investigation (15.11.2003)
Published in The Journal of clinical investigation (15.11.2003)
Get full text
Journal Article
The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance
Liang, Zhanfeng, Zhang, Zhaoqi, Zhang, Qian, Dong, Xue, Yang, Xiaofeng, Zhang, Jiayu, Lei, Tong, Creemers, John W.M., Zhang, Baojun, Zhao, Yong
Published in iScience (21.10.2022)
Published in iScience (21.10.2022)
Get full text
Journal Article
SCAMP5, NBEA and AMISYN: three candidate genes for autism involved in secretion of large dense-core vesicles
Castermans, Dries, Volders, Karolien, Crepel, An, Backx, Liesbeth, De Vos, Rita, Freson, Kathleen, Meulemans, Sandra, Vermeesch, Joris R., Schrander-Stumpel, Connie T.R.M., De Rijk, Peter, Del-Favero, Jurgen, Van Geet, Chris, Van De Ven, Wim J.M., Steyaert, Jean G., Devriendt, Koen, Creemers, John W.M.
Published in Human molecular genetics (01.04.2010)
Published in Human molecular genetics (01.04.2010)
Get full text
Journal Article
Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate
Louagie, Els, Taylor, Neil A, Flamez, Daisy, Roebroek, Anton J.M, Bright, Nicholas A, Meulemans, Sandra, Quintens, Roel, Herrera, Pedro L, Schuit, Frans, Van de Ven, Wim J.M, Creemers, John W.M
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2008)
Get full text
Journal Article
Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function
Rosier, Karen, McDevitt, Molly T., Smet, Joél, Floyd, Brendan J., Verschoore, Maxime, Marcaida, Maria J., Bingman, Craig A., Lemmens, Irma, Dal Peraro, Matteo, Tavernier, Jan, Cravatt, Benjamin F., Gounko, Natalia V., Vints, Katlijn, Monnens, Yenthe, Bhalla, Kritika, Aerts, Laetitia, Rashan, Edrees H., Vanlander, Arnaud V., Van Coster, Rudy, Régal, Luc, Pagliarini, David J., Creemers, John W.M.
Published in iScience (17.12.2021)
Published in iScience (17.12.2021)
Get full text
Journal Article
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
Challis, Benjamin G., Pritchard, Lynn E., Creemers, John W.M., Delplanque, Jerome, Keogh, Julia M., Luan, Jian'an, Wareham, Nicholas J., Yeo, Giles S.H., Bhattacharyya, Sumit, Froguel, Phillipe, White, Anne, Farooqi, I. Sadaf, O'Rahilly, Stephen
Published in Human molecular genetics (15.08.2002)
Published in Human molecular genetics (15.08.2002)
Get full text
Journal Article
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth
Creemers, John W. M., Khatib, Abdel-Majid, Prat, Annik, Meulemans, Sandra, Tuand, Krizia, Stijnen, Pieter, Pruniau, Vincent P. E. G., Brouwers, Bas, Declercq, Jeroen, Seidah, Nabil G.
Published in BioMed research international (01.01.2015)
Published in BioMed research international (01.01.2015)
Get full text
Journal Article
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
Creemers, John W.M, Jackson, Robert S, Montague, Carl T, Ohagi, Shinya, Raffin-Sanson, Marie-Laure, Hutton, John C, O'Rahilly, Stephen, Sanders, Louise
Published in Nature genetics (01.07.1997)
Published in Nature genetics (01.07.1997)
Get full text
Journal Article
Limited Redundancy of the Proprotein Convertase Furin in Mouse Liver
Roebroek, Anton J.M., Taylor, Neil A., Louagie, Els, Pauli, Ilse, Smeijers, Liesbeth, Snellinx, An, Lauwers, Annick, Van de Ven, Wim J.M., Hartmann, Dieter, Creemers, John W.M.
Published in The Journal of biological chemistry (17.12.2004)
Published in The Journal of biological chemistry (17.12.2004)
Get full text
Journal Article