INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses
Sulzmaier, Florian J, Kern, Nadja, Ahn, Sae Jeong, Polovina, Anya, Ho, Jason, Hussain, Abrahim, Cyprus, Garrett, Macedo, Chelsie, Pandit, Rajay, Crago, William, Rowell, Emily, Timmer, John C, Eckelman, Brendan P
Published in Journal for immunotherapy of cancer (01.01.2023)
Published in Journal for immunotherapy of cancer (01.01.2023)
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Journal Article
856 INBRX-106: a novel hexavalent anti-OX40 agonist for the treatment of solid tumors
Rowell, Emily, Kinkead, Heather, Torretti, Elisabeth, Becklund, Bryan, Sulzmaier, Florian, Crago, William, Jones, Kyle, Timmer, John, Deveraux, Quinn, Eckelman, Brendan, Heidt, Analeah
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
722 INBRX-121 is an NKp46-targeted detuned IL-2 with antitumor activity as a monotherapy or in combination with multiple cancer immunotherapy modalities
Sulzmaier, Florian, Kinkead, Heather, Polovina, Anya, Kern, Nadja, Sanabria, Angelica, Macedo, Chelsie, Hussain, Abrahim, Ahn, Sae Jeong, Pandit, Rajay, Crago, William, Timmer, John, Heidt, Analeah, Eckelman, Brendan
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma
Subbiah, Vivek, Chawla, Sant P, Conley, Anthony P, Wilky, Breelyn A, Tolcher, Anthony, Lakhani, Nehal J, Berz, David, Andrianov, Vasily, Crago, William, Holcomb, Monica, Hussain, Abrahim, Veldstra, Carson, Kalabus, James, O'Neill, Brianne, Senne, Lane, Rowell, Emily, Heidt, Analeah B, Willis, Katelyn M, Eckelman, Brendan P
Published in Clinical cancer research (15.08.2023)
Published in Clinical cancer research (15.08.2023)
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Journal Article
Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing
Appelbaum, Jacob, Price, April E, Oda, Kaori, Zhang, Joy, Leung, Wai-Hang, Tampella, Giacomo, Xia, Dong, So, Pauline Pl, Hilton, Sarah K, Evandy, Claudya, Sarkar, Semanti, Martin, Unja, Krostag, Anne-Rachel, Leonardi, Marissa, Zak, Daniel E, Logan, Rachael, Lewis, Paula, Franke-Welch, Secil, Ngwenyama, Njabulo, Fitzgerald, Michael, Tulberg, Niklas, Rawlings-Rhea, Stephanie, Gardner, Rebecca A, Jones, Kyle, Sanabria, Angelica, Crago, William, Timmer, John, Hollands, Andrew, Eckelman, Brendan, Bilic, Sanela, Woodworth, Jim, Lamble, Adam, Gregory, Philip D, Jarjour, Jordan, Pogson, Mark, Gustafson, Joshua A, Astrakhan, Alexander, Jensen, Michael C
Published in The Journal of clinical investigation (01.05.2024)
Published in The Journal of clinical investigation (01.05.2024)
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Journal Article
CD28 단일 도메인 항체 및 이의 다가 및 다중특이적 구조체
TIMMER JOHN C, WILLIS KATELYN M, CRAGO WILLIAM S, ECKELMAN BRENDAN P, JACKSON RUTGER H, KAPLAN MICHAEL D
Year of Publication 04.11.2022
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Year of Publication 04.11.2022
Patent
Abstract 3513: INBRX-121, a safe and efficacious molecular targeted cytokine that enhances NK cell-mediated tumor killing
Kinkead, Heather, Sulzmaier, Florian J., Polovina, Anya, Kern, Nadja, Sanabria, Angelica, Ho, Jason, Macedo, Chelsie, Henderson, Ryan, Hussain, Abrahim, Pandit, Rajay, Crago, William, Rowell, Emily, Eckelman, Brendan P.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
CD33 결합 폴리펩타이드 및 이의 용도
GANO JACOB, TIMMER JOHN C, CRAGO WILLIAM, HOLLANDS ANDREW, JONES KYLE, SANABRIA ANGELICA, MA MILTON, ECKELMAN BRENDAN P
Year of Publication 11.01.2022
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Year of Publication 11.01.2022
Patent
OX40 결합 폴리펩티드 및 이의 용도
TIMMER JOHN C, WILLIS KATELYN M, CRAGO WILLIAM, BECKLUND BRYAN, SULZMAIER FLORIAN, ECKELMAN BRENDAN P, JONES KYLE S
Year of Publication 22.04.2021
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Year of Publication 22.04.2021
Patent
CD33 표적화 면역요법
GANO JACOB, TIMMER JOHN C, POGSON MARK, CRAGO WILLIAM, HOLLANDS ANDREW, LEUNG WAI HANG, JONES KYLE, SANABRIA ANGELICA, MA MILTON, ECKELMAN BRENDAN P, JARJOUR JORDAN
Year of Publication 11.03.2022
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Year of Publication 11.03.2022
Patent
DR5 AGONIST AND IAP ANTAGONIST COMBINATION THERAPY
CRAGO, William, HOLCOMB, Monica, WILLIS, Katelyn M, ECKELMAN, Brendan P
Year of Publication 30.11.2023
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Year of Publication 30.11.2023
Patent
OX40-binding polypeptides and uses thereof
Timmer, John C, Becklund, Bryan, Eckelman, Brendan P, Jones, Kyle, Sulzmaier, Florian, Willis, Katelyn, Crago, William
Year of Publication 18.06.2024
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Year of Publication 18.06.2024
Patent
CD8-BINDING POLYPEPTIDES AND USES THEREOF
SULZMAIER, Florian, CRAGO, William, RASCON, Lucas, TIMMER, John C, ECKELMAN, Brendan P
Year of Publication 29.05.2024
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Year of Publication 29.05.2024
Patent
CD123-binding polypeptides and uses thereof
Timmer, John C, Eckelman, Brendan P, Macedo, Chelsie, Jones, Kyle, Ma, Milton, Crago, William, Hollands, Andrew
Year of Publication 05.03.2024
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Year of Publication 05.03.2024
Patent
CD33-binding polypeptides and uses thereof
Timmer, John C, Eckelman, Brendan P, Jones, Kyle S, Ma, Milton, Sanabria, Angelica, Gano, Jacob, Crago, William, Hollands, Andrew
Year of Publication 10.09.2024
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Year of Publication 10.09.2024
Patent
NKP46-BINDING POLYPEPTIDES AND USES THEREOF
SULZMAIER, Florian, CRAGO, William, KERN, Nadja, TIMMER, John C, KINKEAD, Heather, PANDIT, Rajay A, ECKELMAN, Brendan P
Year of Publication 10.07.2024
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Year of Publication 10.07.2024
Patent
OX40-Binding Polypeptides and Uses Thereof
Timmer, John C, Becklund, Bryan, Eckelman, Brendan P, Jones, Kyle, Sulzmaier, Florian, Willis, Katelyn, Crago, William
Year of Publication 27.04.2023
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Year of Publication 27.04.2023
Patent
CD123-Binding Polypeptides and Uses Thereof
Timmer, John C, Eckelman, Brendan P, Macedo, Chelsie, Jones, Kyle, Ma, Milton, Crago, William, Hollands, Andrew
Year of Publication 02.03.2023
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Year of Publication 02.03.2023
Patent
CD8-BINDING POLYPEPTIDES AND USES THEREOF
TIMMER, JOHN C, ECKELMAN, BRENDAN P, RASCON, LUCAS, SULZMAIER, FLORIAN, CRAGO, WILLIAM
Year of Publication 26.01.2023
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Year of Publication 26.01.2023
Patent