Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS
Coyne, Alyssa N, Baskerville, Victoria, Zaepfel, Benjamin L, Dickson, Dennis W, Rigo, Frank, Bennett, Frank, Lusk, C Patrick, Rothstein, Jeffrey D
Published in Science translational medicine (28.07.2021)
Published in Science translational medicine (28.07.2021)
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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
Coyne, Alyssa N., Zaepfel, Benjamin L., Hayes, Lindsey, Fitchman, Boris, Salzberg, Yuval, Luo, En-Ching, Bowen, Kelly, Trost, Hannah, Aigner, Stefan, Rigo, Frank, Yeo, Gene W., Harel, Amnon, Svendsen, Clive N., Sareen, Dhruv, Rothstein, Jeffrey D.
Published in Neuron (Cambridge, Mass.) (23.09.2020)
Published in Neuron (Cambridge, Mass.) (23.09.2020)
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CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
Cheng, Weiwei, Wang, Shaopeng, Zhang, Zhe, Morgens, David W., Hayes, Lindsey R., Lee, Soojin, Portz, Bede, Xie, Yongzhi, Nguyen, Baotram V., Haney, Michael S., Yan, Shirui, Dong, Daoyuan, Coyne, Alyssa N., Yang, Junhua, Xian, Fengfan, Cleveland, Don W., Qiu, Zhaozhu, Rothstein, Jeffrey D., Shorter, James, Gao, Fen-Biao, Bassik, Michael C., Sun, Shuying
Published in Neuron (Cambridge, Mass.) (04.12.2019)
Published in Neuron (Cambridge, Mass.) (04.12.2019)
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Endocytosis regulates TDP-43 toxicity and turnover
Liu, Guangbo, Coyne, Alyssa N, Pei, Fen, Vaughan, Spencer, Chaung, Matthew, Zarnescu, Daniela C, Buchan, J Ross
Published in Nature communications (12.12.2017)
Published in Nature communications (12.12.2017)
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Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS
Coyne, Alyssa N., Lorenzini, Ileana, Chou, Ching-Chieh, Torvund, Meaghan, Rogers, Robert S., Starr, Alexander, Zaepfel, Benjamin L., Levy, Jennifer, Johannesmeyer, Jeffrey, Schwartz, Jacob C., Nishimune, Hiroshi, Zinsmaier, Konrad, Rossoll, Wilfried, Sattler, Rita, Zarnescu, Daniela C.
Published in Cell reports (Cambridge) (03.10.2017)
Published in Cell reports (Cambridge) (03.10.2017)
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Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS
Coyne, Alyssa N, Zaepfel, Benjamin L, Zarnescu, Daniela C
Published in Frontiers in cellular neuroscience (17.08.2017)
Published in Frontiers in cellular neuroscience (17.08.2017)
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UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
Zaepfel, Benjamin L., Zhang, Zhe, Maulding, Kirstin, Coyne, Alyssa N., Cheng, Weiwei, Hayes, Lindsey R., Lloyd, Thomas E., Sun, Shuying, Rothstein, Jeffrey D.
Published in Cell reports (Cambridge) (30.03.2021)
Published in Cell reports (Cambridge) (30.03.2021)
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Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD
Coyne, Alyssa N, Rothstein, Jeffrey D
Published in Acta neuropathologica communications (19.03.2021)
Published in Acta neuropathologica communications (19.03.2021)
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Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
Zhang, Ke, Daigle, J. Gavin, Cunningham, Kathleen M., Coyne, Alyssa N., Ruan, Kai, Grima, Jonathan C., Bowen, Kelly E., Wadhwa, Harsh, Yang, Peiguo, Rigo, Frank, Taylor, J. Paul, Gitler, Aaron D., Rothstein, Jeffrey D., Lloyd, Thomas E.
Published in Cell (03.05.2018)
Published in Cell (03.05.2018)
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Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis
Coyne, Alyssa N, Siddegowda, Bhavani Bagevalu, Estes, Patricia S, Johannesmeyer, Jeffrey, Kovalik, Tina, Daniel, Scott G, Pearson, Antony, Bowser, Robert, Zarnescu, Daniela C
Published in The Journal of neuroscience (26.11.2014)
Published in The Journal of neuroscience (26.11.2014)
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G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons
Rothstein, Jeffrey D., Baskerville, Victoria, Rapuri, Sampath, Mehlhop, Emma, Jafar-Nejad, Paymaan, Rigo, Frank, Bennett, Frank, Mizielinska, Sarah, Isaacs, Adrian, Coyne, Alyssa N.
Published in Acta neuropathologica (01.06.2024)
Published in Acta neuropathologica (01.06.2024)
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Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models
Bush, Jessica A, Aikawa, Haruo, Fuerst, Rita, Li, Yue, Ursu, Andrei, Meyer, Samantha M, Benhamou, Raphael I, Chen, Jonathan L, Khan, Tanya, Wagner-Griffin, Sarah, Van Meter, Montina J, Tong, Yuquan, Olafson, Hailey, McKee, Kendra K, Childs-Disney, Jessica L, Gendron, Tania F, Zhang, Yongjie, Coyne, Alyssa N, Wang, Eric T, Yildirim, Ilyas, Wang, Kye Won, Petrucelli, Leonard, Rothstein, Jeffrey D, Disney, Matthew D
Published in Science translational medicine (27.10.2021)
Published in Science translational medicine (27.10.2021)
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