PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins
McEwan, David G., Popovic, Doris, Gubas, Andrea, Terawaki, Seigo, Suzuki, Hironori, Stadel, Daniela, Coxon, Fraser P., Miranda de Stegmann, Diana, Bhogaraju, Sagar, Maddi, Karthik, Kirchof, Anja, Gatti, Evelina, Helfrich, Miep H., Wakatsuki, Soichi, Behrends, Christian, Pierre, Philippe, Dikic, Ivan
Published in Molecular cell (08.01.2015)
Published in Molecular cell (08.01.2015)
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Journal Article
Biochemical and molecular mechanisms of action of bisphosphonates
Rogers, Michael J, Crockett, Julie C, Coxon, Fraser P, Mönkkönen, Jukka
Published in Bone (New York, N.Y.) (01.07.2011)
Published in Bone (New York, N.Y.) (01.07.2011)
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Journal Article
PLEKHM1 Regulates Salmonella-Containing Vacuole Biogenesis and Infection
McEwan, David G., Richter, Benjamin, Claudi, Beatrice, Wigge, Christoph, Wild, Philipp, Farhan, Hesso, McGourty, Kieran, Coxon, Fraser P., Franz-Wachtel, Mirita, Perdu, Bram, Akutsu, Masato, Habermann, Anja, Kirchof, Anja, Helfrich, Miep H., Odgren, Paul R., Van Hul, Wim, Frangakis, Achilleas S., Rajalingam, Krishnaraj, Macek, Boris, Holden, David W., Bumann, Dirk, Dikic, Ivan
Published in Cell host & microbe (14.01.2015)
Published in Cell host & microbe (14.01.2015)
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Journal Article
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Frattini, Annalisa, Sobacchi, Cristina, Guerrini, Matteo M, Abinun, Mario, Pangrazio, Alessandra, Susani, Lucia, Bredius, Robbert, Mancini, Grazia, Cant, Andrew, Bishop, Nick, Grabowski, Peter, Del Fattore, Andrea, Messina, Chiara, Errigo, Gabriella, Coxon, Fraser P, Scott, Debbie I, Teti, Anna, Rogers, Michael J, Vezzoni, Paolo, Villa, Anna, Helfrich, Miep H
Published in Nature genetics (01.08.2007)
Published in Nature genetics (01.08.2007)
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Journal Article
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
Coxon, Fraser P, Thompson, Keith, Roelofs, Anke J, Ebetino, F. Hal, Rogers, Michael J
Published in Bone (New York, N.Y.) (01.05.2008)
Published in Bone (New York, N.Y.) (01.05.2008)
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Journal Article
SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts
Stattin, Eva-Lena, Henning, Petra, Klar, Joakim, McDermott, Emma, Stecksen-Blicks, Christina, Sandström, Per-Erik, Kellgren, Therese G., Rydén, Patrik, Hallmans, Göran, Lönnerholm, Torsten, Ameur, Adam, Helfrich, Miep H., Coxon, Fraser P., Dahl, Niklas, Wikström, Johan, Lerner, Ulf H.
Published in Scientific reports (07.06.2017)
Published in Scientific reports (07.06.2017)
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Journal Article
Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
Roelofs, Anke J, Stewart, Charlotte A, Sun, Shuting, Błażewska, Katarzyna M, Kashemirov, Boris A, McKenna, Charles E, Russell, R Graham G, Rogers, Michael J, Lundy, Mark W, Ebetino, Frank H, Coxon, Fraser P
Published in Journal of bone and mineral research (01.04.2012)
Published in Journal of bone and mineral research (01.04.2012)
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Journal Article
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans
Van Wesenbeeck, Liesbeth, Odgren, Paul R, Coxon, Fraser P, Frattini, Annalisa, Moens, Pierre, Perdu, Bram, MacKay, Carole A, Van Hul, Els, Timmermans, Jean-Pierre, Vanhoenacker, Filip, Jacobs, Ruben, Peruzzi, Barbara, Teti, Anna, Helfrich, Miep H, Rogers, Michael J, Villa, Anna, Van Hul, Wim
Published in The Journal of clinical investigation (01.04.2007)
Published in The Journal of clinical investigation (01.04.2007)
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Journal Article
Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine
Sun, Shuting, Błażewska, Katarzyna M, Kadina, Anastasia P, Kashemirov, Boris A, Duan, Xuchen, Triffitt, James T, Dunford, James E, Russell, R. Graham G, Ebetino, Frank H, Roelofs, Anke J, Coxon, Fraser P, Lundy, Mark W, McKenna, Charles E
Published in Bioconjugate chemistry (17.02.2016)
Published in Bioconjugate chemistry (17.02.2016)
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Journal Article
Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors
Vermeer, Jenny A.F, Jansen, Ineke D.C, Marthi, Matangi, Coxon, Fraser P, McKenna, Charles E, Sun, Shuting, de Vries, Teun J, Everts, Vincent
Published in Bone (New York, N.Y.) (01.11.2013)
Published in Bone (New York, N.Y.) (01.11.2013)
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Journal Article
Osteopetrosis: genetics, treatment and new insights into osteoclast function
Sobacchi, Cristina, Schulz, Ansgar, Coxon, Fraser P., Villa, Anna, Helfrich, Miep H.
Published in Nature reviews. Endocrinology (01.09.2013)
Published in Nature reviews. Endocrinology (01.09.2013)
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Journal Article
Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid
McKenna, Charles E, Kashemirov, Boris A, Błażewska, Katarzyna M, Mallard-Favier, Isabelle, Stewart, Charlotte A, Rojas, Javier, Lundy, Mark W, Ebetino, Frank H, Baron, Rudi A, Dunford, James E, Kirsten, Marie L, Seabra, Miguel C, Bala, Joy L, Marma, Mong S, Rogers, Michael J, Coxon, Fraser P
Published in Journal of medicinal chemistry (13.05.2010)
Published in Journal of medicinal chemistry (13.05.2010)
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Journal Article
Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
Baron, Rudi A., Tavaré, Richard, Figueiredo, Ana C., Błazżewska, Katarzyna M., Kashemirov, Boris A., McKenna, Charles E., Ebetino, Frank H., Taylor, Adam, Rogers, Michael J., Coxon, Fraser P., Seabra, Miguel C.
Published in The Journal of biological chemistry (13.03.2009)
Published in The Journal of biological chemistry (13.03.2009)
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Journal Article
Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo
Coxon, Fraser P., Ebetino, Frank H., Mules, Emilie H., Seabra, Miguel C., McKenna, Charles E., Rogers, Michael J.
Published in Bone (New York, N.Y.) (01.09.2005)
Published in Bone (New York, N.Y.) (01.09.2005)
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Journal Article
Bone remodelling at a glance
Crockett, Julie C, Rogers, Michael J, Coxon, Fraser P, Hocking, Lynne J, Helfrich, Miep H
Published in Journal of cell science (01.04.2011)
Published in Journal of cell science (01.04.2011)
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Journal Article
Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI‐298
Coxon, Fraser P., Helfrich, Miep H., Van't Hof, Robert, Sebti, Saïd, Ralston, Stuart H., Hamilton, Andrew, Rogers, Michael J.
Published in Journal of bone and mineral research (01.08.2000)
Published in Journal of bone and mineral research (01.08.2000)
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