Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
Lim, Sean H., Vaughan, Andrew T., Ashton-Key, Margaret, Williams, Emily L., Dixon, Sandra V., Chan, H. T. Claude, Beers, Stephen A., French, Ruth R., Cox, Kerry L., Davies, Andrew J., Potter, Kathleen N., Mockridge, C. Ian, Oscier, David G., Johnson, Peter W.M., Cragg, Mark S., Glennie, Martin J.
Published in Blood (01.09.2011)
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Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo
Roghanian, Ali, Teige, Ingrid, Mårtensson, Linda, Cox, Kerry L., Kovacek, Mathilda, Ljungars, Anne, Mattson, Jenny, Sundberg, Annika, Vaughan, Andrew T., Shah, Vallari, Smyth, Neil R., Sheth, Bhavwanti, Chan, H.T. Claude, Li, Zhan-Chun, Williams, Emily L., Manfredi, Giusi, Oldham, Robert J., Mockridge, C. Ian, James, Sonya A., Dahal, Lekh N., Hussain, Khiyam, Nilsson, Björn, Verbeek, J. Sjef, Juliusson, Gunnar, Hansson, Markus, Jerkeman, Mats, Johnson, Peter W.M., Davies, Andrew, Beers, Stephen A., Glennie, Martin J., Frendéus, Björn, Cragg, Mark S.
Published in Cancer cell (13.04.2015)
Published in Cancer cell (13.04.2015)
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Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
Beers, Stephen A., French, Ruth R., Chan, H.T. Claude, Lim, Sean H., Jarrett, Timothy C., Vidal, Regina Mora, Wijayaweera, Sahan S., Dixon, Sandra V., Kim, Hyungjin, Cox, Kerry L., Kerr, Jonathan P., Johnston, David A., Johnson, Peter W.M., Verbeek, J. Sjef, Glennie, Martin J., Cragg, Mark S.
Published in Blood (24.06.2010)
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Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinations
Willoughby, Jane E, Dou, Lang, Bhattacharya, Sabyasachi, Jackson, Heather, Seestaller-Wehr, Laura, Kilian, David, Bover, Laura, Voo, Kui S, Cox, Kerry L, Murray, Tom, John, Mel, Shi, Hong, Bojczuk, Paul, Jing, Junping, Niederer, Heather, Shepherd, Andrew J, Hook, Laura, Hopley, Stephanie, Inzhelevskaya, Tatyana, Penfold, Chris A, Mockridge, C Ian, English, Vikki, Brett, Sara J, Srinivasan, Roopa, Hopson, Christopher, Smothers, James, Hoos, Axel, Paul, Elaine, Martin, Stephen L, Morley, Peter J, Yanamandra, Niranjan, Cragg, Mark S
Published in Journal for immunotherapy of cancer (01.07.2024)
Published in Journal for immunotherapy of cancer (01.07.2024)
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Domain binding and isotype dictate the activity of anti-human OX40 antibodies
Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S
Published in Journal for immunotherapy of cancer (01.12.2020)
Published in Journal for immunotherapy of cancer (01.12.2020)
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Reducing affinity as a strategy to boost immunomodulatory antibody agonism
Yu, Xiaojie, Orr, Christian M, Chan, H T Claude, James, Sonya, Penfold, Christine A, Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C Ian, Cox, Kerry L, Essex, Jonathan W, Tews, Ivo, Glennie, Martin J, Cragg, Mark S
Published in Nature (London) (16.02.2023)
Published in Nature (London) (16.02.2023)
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STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy
Dahal, Lekh N, Dou, Lang, Hussain, Khiyam, Liu, Rena, Earley, Alexander, Cox, Kerry L, Murinello, Salome, Tracy, Ian, Forconi, Francesco, Steele, Andrew J, Duriez, Patrick J, Gomez-Nicola, Diego, Teeling, Jessica L, Glennie, Martin J, Cragg, Mark S, Beers, Stephen A
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
Mellone, Massimiliano, Piotrowska, Klaudia, Venturi, Giulia, James, Lija, Bzura, Aleksandra, Lopez, Maria A, James, Sonya, Wang, Chuan, Ellis, Matthew J, Hanley, Christopher J, Buckingham, Josephine F, Cox, Kerry L, Hughes, Gareth, Valge-Archer, Viia, King, Emma V, Beers, Stephen A, Jaquet, Vincent, Jones, George D D, Savelyeva, Natalia, Sayan, Emre, Parsons, Jason L, Durant, Stephen, Thomas, Gareth J
Published in Cancer research (Chicago, Ill.) (16.12.2022)
Published in Cancer research (Chicago, Ill.) (16.12.2022)
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Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies
Tipton, Thomas R.W., Roghanian, Ali, Oldham, Robert J., Carter, Matthew J., Cox, Kerry L., Mockridge, C. Ian, French, Ruth R., Dahal, Lekh N., Duriez, Patrick J., Hargreaves, Philip G., Cragg, Mark S., Beers, Stephen A.
Published in Blood (19.03.2015)
Published in Blood (19.03.2015)
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Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment
Turaj, Anna H., Hussain, Khiyam, Cox, Kerry L., Rose-Zerilli, Matthew J.J., Testa, James, Dahal, Lekh N., Chan, H.T. Claude, James, Sonya, Field, Vikki L., Carter, Matthew J., Kim, Hyung J., West, Jonathan J., Thomas, Lawrence J., He, Li-Zhen, Keler, Tibor, Johnson, Peter W.M., Al-Shamkhani, Aymen, Thirdborough, Stephen M., Beers, Stephen A., Cragg, Mark S., Glennie, Martin J., Lim, Sean H.
Published in Cancer cell (11.12.2017)
Published in Cancer cell (11.12.2017)
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Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
Ivanov, Andrei, Beers, Stephen A, Walshe, Claire A, Honeychurch, Jamie, Alduaij, Waleed, Cox, Kerry L, Potter, Kathleen N, Murray, Stephen, Chan, Claude H T, Klymenko, Tetyana, Erenpreisa, Jekaterina, Glennie, Martin J, Illidge, Tim M, Cragg, Mark S
Published in The Journal of clinical investigation (01.08.2009)
Published in The Journal of clinical investigation (01.08.2009)
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Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking
Turaj, Anna H, Cox, Kerry L, Penfold, Christine A, French, Ruth R, Mockridge, C Ian, Willoughby, Jane E, Tutt, Alison L, Griffiths, Jordana, Johnson, Peter W M, Glennie, Martin J, Levy, Ronald, Cragg, Mark S, Lim, Sean H
Published in Scientific reports (02.02.2018)
Published in Scientific reports (02.02.2018)
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FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms
Simpson, Alexander P., Roghanian, Ali, Oldham, Robert J., Chan, H.T. Claude, Penfold, Christine A., Kim, Hyung J., Inzhelevskaya, Tatyana, Mockridge, C. Ian, Cox, Kerry L., Bogdanov, Yury D., James, Sonya, Tutt, Alison L., Rycroft, Daniel, Morley, Peter, Dahal, Lekh N., Teige, Ingrid, Frendeus, Björn, Beers, Stephen A., Cragg, Mark S.
Published in Cell reports (Cambridge) (19.07.2022)
Published in Cell reports (Cambridge) (19.07.2022)
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The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo
Palazzo, Adam, Herter, Sylvia, Grosmaire, Laura, Jones, Randy, Frey, Christian R, Limani, Florian, Bacac, Marina, Umana, Pablo, Oldham, Robert J, Marshall, Michael J E, Cox, Kerry L, Turaj, Anna H, Cragg, Mark S, Klein, Christian, Carter, Matthew J, Tannheimer, Stacey
Published in The Journal of immunology (1950) (01.04.2018)
Published in The Journal of immunology (1950) (01.04.2018)
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Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures
Johnston, Harvey E., Carter, Matthew J., Cox, Kerry L., Dunscombe, Melanie, Manousopoulou, Antigoni, Townsend, Paul A., Garbis, Spiros D., Cragg, Mark S.
Published in Molecular & cellular proteomics (01.03.2017)
Published in Molecular & cellular proteomics (01.03.2017)
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Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors
Tutt, Alison L, James, Sonya, Laversin, Stéphanie A, Tipton, Thomas R W, Ashton-Key, Margaret, French, Ruth R, Hussain, Khiyam, Vaughan, Andrew T, Dou, Lang, Earley, Alexander, Dahal, Lekh N, Lu, Chen, Dunscombe, Melanie, Chan, H T Claude, Penfold, Christine A, Kim, Jinny H, Potter, Elizabeth A, Mockridge, C Ian, Roghanian, Ali, Oldham, Robert J, Cox, Kerry L, Lim, Sean H, Teige, Ingrid, Frendéus, Bjorn, Glennie, Martin J, Beers, Stephen A, Cragg, Mark S
Published in The Journal of immunology (1950) (01.12.2015)
Published in The Journal of immunology (1950) (01.12.2015)
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BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression
Cummin, ThomasE.C., Cox, Kerry L., Murray, Tom D., Turaj, Anna H., Dunning, Lisa, English, Vikki L., Fell, Rachel, Packham, Graham, Ma, Yan, Powell, Ben, Johnson, PeterW.M., Cragg, Mark S., Carter, Matthew J.
Published in Blood advances (28.07.2020)
Published in Blood advances (28.07.2020)
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Development and characterisation of monoclonal antibodies specific for the murine inhibitory FcγRIIB (CD32B)
Williams, Emily L., Tutt, Alison L., French, Ruth R., Chan, H. T. Claude, Lau, Betty, Penfold, Christine A., Mockridge, C. Ian, Roghanian, Ali, Cox, Kerry L., Verbeek, J. Sjef, Glennie, Martin J., Cragg, Mark S.
Published in European journal of immunology (01.08.2012)
Published in European journal of immunology (01.08.2012)
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Immunotherapy targeting inhibitory Fcγ receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization
Williams, Emily L, Tutt, Alison L, Beers, Stephen A, French, Ruth R, Chan, Claude H T, Cox, Kerry L, Roghanian, Ali, Penfold, Christine A, Butts, Cherié L, Boross, Peter, Verbeek, J Sjef, Cragg, Mark S, Glennie, Martin J
Published in The Journal of immunology (1950) (15.10.2013)
Published in The Journal of immunology (1950) (15.10.2013)
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FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion
Oldham, Robert J, Mockridge, C Ian, James, Sonya, Duriez, Patrick J, Chan, H T Claude, Cox, Kerry L, Pitic, Vicentiu A, Glennie, Martin J, Cragg, Mark S
Published in Journal for immunotherapy of cancer (01.06.2020)
Published in Journal for immunotherapy of cancer (01.06.2020)
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