Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples
Korfmacher, Walter A., Veals, John, Dunn-Meynell, Kimberly, Zhang, Xiping, Tucker, Greg, Cox, Kathleen A., Lin, Chin-Chung
Published in Rapid communications in mass spectrometry (30.10.1999)
Published in Rapid communications in mass spectrometry (30.10.1999)
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Journal Article
Improving the Oral Efficacy of CNS Drug Candidates: Discovery of Highly Orally Efficacious Piperidinyl Piperidine M2 Muscarinic Receptor Antagonists
Wang, Yuguang, Chackalamannil, Samuel, Hu, Zhiyong, Greenlee, William J, Clader, John, Boyle, Craig D, Kaminski, James J, Billard, William, Binch, Crosby, Gordon, Ruperto, Vilma, Duffy, Ruth A, Cohen-Williams, Mary, Coffin, Vicki L, Cox, Kathleen A, Grotz, Diane E, Lachowicz, Jean E
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Journal Article
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification
BOYLE, Craig D, VICE, Susan F, COFFIN, Vicki L, COX, Kathleen A, GROTZ, Diane E, DUFFY, Ruth A, RUPERTO, Vilma, LACHOWICZ, Jean E, CAMPION, Jennifer, CHACKALAMANNIL, Samuel, LANKIN, Claire M, MCCOMBIE, Stuart W, BILLARD, William, BINCH, Herbert III, CROSBY, Gordon, WILLIAMS, Mary-Cohen
Published in Bioorganic & medicinal chemistry letters (01.12.2002)
Published in Bioorganic & medicinal chemistry letters (01.12.2002)
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Journal Article
Resonance Ejection Ion Trap Mass Spectrometry and Nonlinear Field Contributions: The Effect of Scan Direction on Mass Resolution
Williams, Jon D, Cox, Kathleen A, Cooks, R. Graham, McLuckey, Scott A, Hart, Kevin J, Goeringer, Douglas E
Published in Analytical chemistry (Washington) (01.03.1994)
Published in Analytical chemistry (Washington) (01.03.1994)
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Journal Article
Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution
BOYLE, Craig D, CHACKALAMANNIL, Samuel, YUGUANG WANG, GUOWEI ZHOU, BILLARD, William, BINCH, Herbert III, CROSBY, Gordon, COHEN-WILLIAMS, Mary, COFFIN, Vicki L, COX, Kathleen A, GROTZ, Diane E, DUFFY, Ruth A, CLADER, John W, RUPERTO, Vilma, LACHOWICZ, Jean E, GREENLEE, William J, JOSIEN, Hubert B, KAMINSKI, James J, KOZLOWSKI, Joseph A, MCCOMBIE, Stuart W, NAZARENO, Dennis V, TAGAT, Jayaram R
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Journal Article
Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy
Kim, Hong, Feng, Wenqing, Chan, Tze-Ming, Rindgen, Diane, Bryant, Matthew, Cox, Kathleen A., Xia, Yan, Reichard, Gregory, Paliwal, Sunil, Hesk, David, Palamanda, Jairam, White, Ronald E., Nomeir, Amin A.
Published in Journal of separation science (01.10.2002)
Published in Journal of separation science (01.10.2002)
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Journal Article
Systematic LC/MS metabolite identification in drug discovery
Clarke, N J, Rindgen, D, Korfmacher, W A, Cox, K A
Published in Analytical chemistry (Washington) (01.08.2001)
Published in Analytical chemistry (Washington) (01.08.2001)
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Journal Article
Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery
Korfmacher, Walter A., Cox, Kathleen A., Ng, Kwokei J., Veals, John, Hsieh, Yunsheng, Wainhaus, Sam, Broske, Lisa, Prelusky, Dan, Nomeir, Amin, White, Ronald E.
Published in Rapid communications in mass spectrometry (01.01.2001)
Published in Rapid communications in mass spectrometry (01.01.2001)
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Journal Article
Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats
Cox, Kathleen A., Dunn-Meynell, Kimberly, Korfmacher, Walter A., Broske, Lisa, Nomeir, Amin A., Lin, Chin-Chung, Cayen, Mitchell N., Barr, William H.
Published in Drug Discovery Today (01.05.1999)
Published in Drug Discovery Today (01.05.1999)
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Book Review
Journal Article
Molecular heterogeneity in the Major Urinary Proteins of the house mouse Mus musculus
Robertson, D H, Cox, K A, Gaskell, S J, Evershed, R P, Beynon, R J
Published in Biochemical journal (15.05.1996)
Published in Biochemical journal (15.05.1996)
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Journal Article
Peer Reviewed: Systematic LC/MS Metabolite Identification in Drug Discovery
CLARKE, Nigel J., RINDGEN, Diane, KORFMACHER, Walter A., COX, Kathleen A.
Published in Analytical chemistry (Washington) (01.08.2001)
Published in Analytical chemistry (Washington) (01.08.2001)
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Journal Article
Systematic LC/MS metabolite identification in drigs discovery
CLARKE, Nigel J, RINDGEN, Diane, KORFMACHER, Walter A, COX, Kathleen A
Published in Analytical chemistry (Washington) (2001)
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Published in Analytical chemistry (Washington) (2001)
Journal Article
Improving the oral efficacy of CNS drug candidates: Discovery of highly orally efficacious piperidinyl piperidine M-2 muscarinic receptor antagonists
Wang, YG, Chackalamannil, S, Hu, ZY, Greenlee, WJ, Clader, J, Boyle, CD, Kaminski, JJ, Billard, W, Binch, H, Crosby, G, Ruperto, Duffy, RA, Cohen-Williams, M, Coffin, VL, Cox, KA, Grotz, DE, Lachowicz, JE
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Journal Article
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M 2 muscarinic receptor antagonists via benzamide modification
Boyle, Craig D., Vice, Susan F., Campion, Jennifer, Chackalamannil, Samuel, Lankin, Claire M., McCombie, Stuart W., Billard, William, Binch, III, Herbert, Crosby, Gordon, Williams, Mary-Cohen, Coffin, Vicki L., Cox, Kathleen A., Grotz, Diane E., Duffy, Ruth A., Ruperto, Vilma, Lachowicz, Jean E.
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Journal Article
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification
Boyle, Craig D, Vice, Susan F, Campion, Jennifer, Chackalamannil, Samuel, Lankin, Claire M, McCombie, Stuart W, Billard, William, Binch, 3rd, Herbert, Crosby, Gordon, Williams, Mary-Cohen, Coffin, Vicki L, Cox, Kathleen A, Grotz, Diane E, Duffy, Ruth A, Ruperto, Vilma, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Journal Article
Metabolic stabilization of benzylidene ketal M 2 muscarinic receptor antagonists via halonaphthoic acid substitution
Boyle, Craig D., Chackalamannil, Samuel, Clader, John W., Greenlee, William J., Josien, Hubert B., Kaminski, James J., Kozlowski, Joseph A., McCombie, Stuart W., Nazareno, Dennis V., Tagat, Jayaram R., Wang, Yuguang, Zhou, Guowei, Billard, William, Binch, Herbert, Crosby, Gordon, Cohen-Williams, Mary, Coffin, Vicki L., Cox, Kathleen A., Grotz, Diane E., Duffy, Ruth A., Ruperto, Vilma, Lachowicz, Jean E.
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Journal Article