Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML
Puram, Rishi V., Kowalczyk, Monika S., de Boer, Carl G., Schneider, Rebekka K., Miller, Peter G., McConkey, Marie, Tothova, Zuzana, Tejero, Héctor, Heckl, Dirk, Järås, Marcus, Chen, Michelle C., Li, Hubo, Tamayo, Alfred, Cowley, Glenn S., Rozenblatt-Rosen, Orit, Al-Shahrour, Fatima, Regev, Aviv, Ebert, Benjamin L.
Published in Cell (07.04.2016)
Published in Cell (07.04.2016)
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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
Rosenbluh, Joseph, Nijhawan, Deepak, Cox, Andrew G., Li, Xingnan, Neal, James T., Schafer, Eric J., Zack, Travis I., Wang, Xiaoxing, Tsherniak, Aviad, Schinzel, Anna C., Shao, Diane D., Schumacher, Steven E., Weir, Barbara A., Vazquez, Francisca, Cowley, Glenn S., Root, David E., Mesirov, Jill P., Beroukhim, Rameen, Kuo, Calvin J., Goessling, Wolfram, Hahn, William C.
Published in Cell (21.12.2012)
Published in Cell (21.12.2012)
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(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
Losman, Julie-Aurore, Looper, Ryan E., Koivunen, Peppi, Lee, Sungwoo, Schneider, Rebekka K., McMahon, Christine, Cowley, Glenn S., Root, David E., Ebert, Benjamin L., Kaelin, William G.
Published in Science (American Association for the Advancement of Science) (29.03.2013)
Published in Science (American Association for the Advancement of Science) (29.03.2013)
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Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
Whittaker, Steven R, Theurillat, Jean-Philippe, Van Allen, Eliezer, Wagle, Nikhil, Hsiao, Jessica, Cowley, Glenn S, Schadendorf, Dirk, Root, David E, Garraway, Levi A
Published in Cancer discovery (01.03.2013)
Published in Cancer discovery (01.03.2013)
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Cancer Vulnerabilities Unveiled by Genomic Loss
Nijhawan, Deepak, Zack, Travis I., Ren, Yin, Strickland, Matthew R., Lamothe, Rebecca, Schumacher, Steven E., Tsherniak, Aviad, Besche, Henrike C., Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A., Goldberg, Alfred L., Mesirov, Jill P., Root, David E., Bhatia, Sangeeta N., Beroukhim, Rameen, Hahn, William C.
Published in Cell (17.08.2012)
Published in Cell (17.08.2012)
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Journal Article
SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer
Li, Lianjie, Shen, Chuan, Nakamura, Eijiro, Ando, Kiyohiro, Signoretti, Sabina, Beroukhim, Rameen, Cowley, Glenn S., Lizotte, Patrick, Liberzon, Ella, Bair, Steven, Root, David E., Tamayo, Pablo, Tsherniak, Aviad, Cheng, Su-Chun, Tabak, Barbara, Jacobsen, Anders, Hakimi, A. Ari, Schultz, Nikolaus, Ciriello, Giovanni, Sander, Chris, Hsieh, James J., Kaelin, William G.
Published in Cancer cell (09.12.2013)
Published in Cancer cell (09.12.2013)
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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity
Ramirez-Ortiz, Zaida G, Prasad, Amit, Griffith, Jason W, Pendergraft, William F, Cowley, Glenn S, Root, David E, Tai, Melissa, Luster, Andrew D, El Khoury, Joseph, Hacohen, Nir, Means, Terry K
Published in Nature immunology (01.05.2015)
Published in Nature immunology (01.05.2015)
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Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease
Shema, Reut, Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2015)
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Journal Article
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
Järås, Marcus, Miller, Peter G, Chu, Lisa P, Puram, Rishi V, Fink, Emma C, Schneider, Rebekka K, Al-Shahrour, Fatima, Peña, Pablo, Breyfogle, L Jordan, Hartwell, Kimberly A, McConkey, Marie E, Cowley, Glenn S, Root, David E, Kharas, Michael G, Mullally, Ann, Ebert, Benjamin L
Published in The Journal of experimental medicine (07.04.2014)
Published in The Journal of experimental medicine (07.04.2014)
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A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor
Eller, Carla, Heydmann, Laura, Colpitts, Che C., El Saghire, Houssein, Piccioni, Federica, Jühling, Frank, Majzoub, Karim, Pons, Caroline, Bach, Charlotte, Lucifora, Julie, Lupberger, Joachim, Nassal, Michael, Cowley, Glenn S., Fujiwara, Naoto, Hsieh, Sen-Yung, Hoshida, Yujin, Felli, Emanuele, Pessaux, Patrick, Sureau, Camille, Schuster, Catherine, Root, David E., Verrier, Eloi R., Baumert, Thomas F.
Published in Nature communications (01.06.2020)
Published in Nature communications (01.06.2020)
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Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8⁺ T-cell effector differentiation
Godec, Jernej, Cowley, Glenn S., Barnitz, R. Anthony, Root, David E., Sharpe, Arlene H., Haining, W. Nicholas
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
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Journal Article
The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation
Bhogal, Balpreet, Weir, Barbara A., Crescenzo, Ramona, Marien, Ann, Kwon, Min Chul, Philippar, Ulrike, Cowley, Glenn S.
Published in Communications biology (03.11.2022)
Published in Communications biology (03.11.2022)
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Journal Article
The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection
Filone, Claire Marie, Caballero, Ignacio S, Dower, Ken, Mendillo, Marc L, Cowley, Glenn S, Santagata, Sandro, Rozelle, Daniel K, Yen, Judy, Rubins, Kathleen H, Hacohen, Nir, Root, David E, Hensley, Lisa E, Connor, John
Published in PLoS pathogens (01.02.2014)
Published in PLoS pathogens (01.02.2014)
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Journal Article
Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis
Nandakumar, Satish K, McFarland, Sean K, Mateyka, Laura M, Lareau, Caleb A, Ulirsch, Jacob C, Ludwig, Leif S, Agarwal, Gaurav, Engreitz, Jesse M, Przychodzen, Bartlomiej, McConkey, Marie, Cowley, Glenn S, Doench, John G, Maciejewski, Jaroslaw P, Ebert, Benjamin L, Root, David E, Sankaran, Vijay G
Published in eLife (09.05.2019)
Published in eLife (09.05.2019)
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Journal Article
Defining a Cancer Dependency Map
Tsherniak, Aviad, Vazquez, Francisca, Montgomery, Phil G., Weir, Barbara A., Kryukov, Gregory, Cowley, Glenn S., Gill, Stanley, Harrington, William F., Pantel, Sasha, Krill-Burger, John M., Meyers, Robin M., Ali, Levi, Goodale, Amy, Lee, Yenarae, Jiang, Guozhi, Hsiao, Jessica, Gerath, William F.J., Howell, Sara, Merkel, Erin, Ghandi, Mahmoud, Garraway, Levi A., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C.
Published in Cell (27.07.2017)
Published in Cell (27.07.2017)
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Journal Article
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
Meyers, Robin M, Bryan, Jordan G, McFarland, James M, Weir, Barbara A, Sizemore, Ann E, Xu, Han, Dharia, Neekesh V, Montgomery, Phillip G, Cowley, Glenn S, Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D, Jiang, Guozhi, Lubonja, Rakela, Harrington, William F, Strickland, Matthew, Wu, Ting, Hawes, Derek C, Zhivich, Victor A, Wyatt, Meghan R, Kalani, Zohra, Chang, Jaime J, Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R, Boehm, Jesse S, Vazquez, Francisca, Root, David E, Hahn, William C, Tsherniak, Aviad
Published in Nature genetics (01.12.2017)
Published in Nature genetics (01.12.2017)
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Journal Article
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Kryukov, Gregory V., Wilson, Frederick H., Ruth, Jason R., Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E., Vazquez, Francisca, Weir, Barbara A., Fitzgerald, Mark E., Tanaka, Minoru, Bielski, Craig M., Scott, Justin M., Dennis, Courtney, Cowley, Glenn S., Boehm, Jesse S., Root, David E., Golub, Todd R., Clish, Clary B., Bradner, James E., Hahn, William C., Garraway, Levi A.
Published in Science (American Association for the Advancement of Science) (11.03.2016)
Published in Science (American Association for the Advancement of Science) (11.03.2016)
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