Imatinib: a selective tyrosine kinase inhibitor
Manley, P.W., Cowan-Jacob, S.W., Buchdunger, E., Fabbro, D., Fendrich, G., Furet, P., Meyer, T., Zimmermann, J.
Published in European journal of cancer (1990) (01.09.2002)
Published in European journal of cancer (1990) (01.09.2002)
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AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL
Weisberg, E, Manley, P, Mestan, J, Cowan-Jacob, S, Ray, A, Griffin, J D
Published in British journal of cancer (19.06.2006)
Published in British journal of cancer (19.06.2006)
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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
Weisberg, Ellen, Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Ray, Arghya, Huntly, Brian, Fabbro, Doriano, Fendrich, Gabriele, Hall-Meyers, Elizabeth, Kung, Andrew L., Mestan, Jürgen, Daley, George Q., Callahan, Linda, Catley, Laurie, Cavazza, Cara, Mohammed, Azam, Neuberg, Donna, Wright, Renee D., Gilliland, D. Gary, Griffin, James D.
Published in Cancer cell (01.02.2005)
Published in Cancer cell (01.02.2005)
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Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana
Prade, L, Cowan-Jacob, S.W, Chemla, P, Potter, S, Ward, E, Fonne-Pfister, R
Published in Journal of molecular biology (18.02.2000)
Published in Journal of molecular biology (18.02.2000)
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The Mode of Action and the Structure of a Herbicide in Complex with its Target: Binding of Activated Hydantocidin to the Feedback Regulation Site of Adenylosuccinate Synthetase
Fonné-Pfister, R., Chemla, P., Ward, E., Girardet, M., Kreuz, K. E., Honzatko, R. B., Fromm, H. J., H.-P. Schär, Grütter, M. G., Cowan-Jacob, S. W.
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.1996)
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Novel Purine Nitrile Derived Inhibitors of the Cysteine Protease Cathepsin K
Altmann, Eva, Cowan-Jacob, Sandra W, Missbach, Martin
Published in Journal of medicinal chemistry (18.11.2004)
Published in Journal of medicinal chemistry (18.11.2004)
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Structural Basis of BFL-1 for Its Interaction with BAX and Its Anti-apoptotic Action in Mammalian and Yeast Cells
Zhang, Hong, Cowan-Jacob, Sandra W., Simonen, Marjo, Greenhalf, William, Heim, Jutta, Meyhack, Bernd
Published in The Journal of biological chemistry (14.04.2000)
Published in The Journal of biological chemistry (14.04.2000)
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Correction: AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL
Weisberg, E, Manley, P, Mestan, J, Cowan-Jacob, S, Ray, A, Griffin, J D
Published in British journal of cancer (01.07.2019)
Published in British journal of cancer (01.07.2019)
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Allosteric Plus Catalytic BCR-ABL1 Inhibitors Promote Durable Responses
Published in Cancer discovery
(01.05.2017)
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In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
O'HARE, Thomas, WALTERS, Denise K, DRUKER, Brian J, STOFFREGEN, Eric P, TAIPING JIA, MANLEY, Paul W, MESTAN, Jürgen, COWAN-JACOB, Sandra W, LEE, Francis Y, HEINRICH, Michael C, DEININGER, Michael W. N
Published in Cancer research (Chicago, Ill.) (01.06.2005)
Published in Cancer research (Chicago, Ill.) (01.06.2005)
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The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation
Cowan-Jacob, Sandra W., Fendrich, Gabriele, Manley, Paul W., Jahnke, Wolfgang, Fabbro, Doriano, Liebetanz, Janis, Meyer, Thomas
Published in Structure (London) (01.06.2005)
Published in Structure (London) (01.06.2005)
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Protein kinases as targets for anticancer agents: from inhibitors to useful drugs
Fabbro, Doriano, Ruetz, Stephan, Buchdunger, Elisabeth, Cowan-Jacob, Sandra W, Fendrich, Gabriele, Liebetanz, Janis, Mestan, Jürgen, O'Reilly, Terence, Traxler, Peter, Chaudhuri, Bhabatosh, Fretz, Heinz, Zimmermann, Jürg, Meyer, Thomas, Caravatti, Giorgio, Furet, Pascal, Manley, Paul W
Published in Pharmacology & therapeutics (Oxford) (01.02.2002)
Published in Pharmacology & therapeutics (Oxford) (01.02.2002)
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Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment
Cowan-Jacob, Sandra W, Guez, Valerie, Fendrich, Gabriele, Griffin, James D, Fabbro, Doriano, Furet, Pascal, Liebetanz, Janis, Mestan, Jürgen, Manley, Paul W
Published in Mini reviews in medicinal chemistry (01.03.2004)
Published in Mini reviews in medicinal chemistry (01.03.2004)
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STI571 (IMATINIB): structural and enzymatic studies of interactions with ABL kinase and resistance mutants
Cowan-Jacob, S. W., Fendrich, G., Guez, V., Liebetanz, J., Fabbro, D., Manley, P. W.
Published in Acta crystallographica. Section A, Foundations of crystallography (06.08.2002)
Published in Acta crystallographica. Section A, Foundations of crystallography (06.08.2002)
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An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase
Hanessian, Stephen, Lu, Pu-Ping, Sancéau, Jean-Yves, Chemla, Philippe, Gohda, Keigo, Fonne-Pfister, Raymonde, Prade, Lars, Cowan-Jacob, Sandra W.
Published in Angewandte Chemie (International ed.) (02.11.1999)
Published in Angewandte Chemie (International ed.) (02.11.1999)
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