Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia
Byrd, John C, Harrington, Bonnie, O’Brien, Susan, Jones, Jeffrey A, Schuh, Anna, Devereux, Steve, Chaves, Jorge, Wierda, William G, Awan, Farrukh T, Brown, Jennifer R, Hillmen, Peter, Stephens, Deborah M, Ghia, Paolo, Barrientos, Jacqueline C, Pagel, John M, Woyach, Jennifer, Johnson, Dave, Huang, Jane, Wang, Xiaolin, Kaptein, Allard, Lannutti, Brian J, Covey, Todd, Fardis, Maria, McGreivy, Jesse, Hamdy, Ahmed, Rothbaum, Wayne, Izumi, Raquel, Diacovo, Thomas G, Johnson, Amy J, Furman, Richard R
Published in The New England journal of medicine (28.01.2016)
Published in The New England journal of medicine (28.01.2016)
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Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
Wang, Michael, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Casasnovas, Olivier, Smith, Stephen D, Damaj, Gandhi, Doorduijn, Jeanette, Lamy, Thierry, Morschhauser, Franck, Panizo, Carlos, Shah, Bijal, Davies, Andrew, Eek, Richard, Dupuis, Jehan, Jacobsen, Eric, Kater, Arnon P, Le Gouill, Steven, Oberic, Lucie, Robak, Taduesz, Covey, Todd, Dua, Richa, Hamdy, Ahmed, Huang, Xin, Izumi, Raquel, Patel, Priti, Rothbaum, Wayne, Slatter, J Greg, Jurczak, Wojciech
Published in The Lancet (British edition) (17.02.2018)
Published in The Lancet (British edition) (17.02.2018)
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The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
Herman, Sarah E M, Montraveta, Arnau, Niemann, Carsten U, Mora-Jensen, Helena, Gulrajani, Michael, Krantz, Fanny, Mantel, Rose, Smith, Lisa L, McClanahan, Fabienne, Harrington, Bonnie K, Colomer, Dolors, Covey, Todd, Byrd, John C, Izumi, Raquel, Kaptein, Allard, Ulrich, Roger, Johnson, Amy J, Lannutti, Brian J, Wiestner, Adrian, Woyach, Jennifer A
Published in Clinical cancer research (01.06.2017)
Published in Clinical cancer research (01.06.2017)
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Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma
Harrington, Bonnie K, Gardner, Heather L, Izumi, Raquel, Hamdy, Ahmed, Rothbaum, Wayne, Coombes, Kevin R, Covey, Todd, Kaptein, Allard, Gulrajani, Michael, Van Lith, Bart, Krejsa, Cecile, Coss, Christopher C, Russell, Duncan S, Zhang, Xiaoli, Urie, Bridget K, London, Cheryl A, Byrd, John C, Johnson, Amy J, Kisseberth, William C
Published in PloS one (19.07.2016)
Published in PloS one (19.07.2016)
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The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia
Danilova, Nadia, Bibikova, Elena, Covey, Todd M, Nathanson, David, Dimitrova, Elizabeth, Konto, Yoan, Lindgren, Anne, Glader, Bertil, Radu, Caius G, Sakamoto, Kathleen M, Lin, Shuo
Published in Disease models & mechanisms (01.07.2014)
Published in Disease models & mechanisms (01.07.2014)
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Potency and Selectivity of BTK Inhibitors in Clinical Development for B-Cell Malignancies
Kaptein, Allard, de Bruin, Gerjan, Emmelot-van Hoek, Maaike, van de Kar, Bas, de Jong, Anouk, Gulrajani, Michael, Demont, Dennis, Covey, Todd, Mittag, Diana, Barf, Tjeerd
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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P1006: CHARACTERIZATION OF TL‐895: A NOVEL BRUTON TYROSINE KINASE INHIBITOR (BTKI) IN CLINICAL DEVELOPMENT FOR CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND MYELOFIBROSIS (MF)
Gulrajani, Michael, Clevenger, Tracy, Cheung, Jean, Krantz, Fanny, Nguyen, Cynthia, Luarca, Miranda, Krejsa, Cecile, Rothbaum, Wayne P., Covey, Todd
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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P991: ADDING NAVTEMADLIN (NVTM) TO RUXOLITINIB (RUX) POTENTIATES APOPTOSIS IN MYELOBLASTS FROM PATIENTS (PTS) WITH MYELOFIBROSIS (MF)
Clevenger, Tracy, Cheung, Jean, Krantz, Fanny, Gulrajani, Michael, Nguyen, Cynthia, Luarca, Miranda, Krejsa, Cecile, Rothbaum, Wayne P., Covey, Todd
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity
Artis, David, Villarino, Alejandro, Silverman, Michael, He, Weimian, Thornton, Elizabeth M, Mu, Sharon, Summer, Shamin, Covey, Todd M, Huang, Elaine, Yoshida, Hiroki, Koretzky, Gary, Goldschmidt, Michael, Wu, Gary D, de Sauvage, Fred, Miller, Hugh R. P, Saris, Christiaan J. M, Scott, Phillip, Hunter, Christopher A
Published in The Journal of immunology (1950) (01.11.2004)
Published in The Journal of immunology (1950) (01.11.2004)
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Journal Article
P1005: EFFECT OF TL‐895, A NOVEL BRUTON’S TYROSINE KINASE INHIBITOR (BTKI), ON ONCOGENIC JANUS KINASE 2‐V617F (JAK2VF) SIGNALING
Chary Nimmagadda, Subbaiah, Marie Budde, Paulina, Sun, Kaiyan, Covey, Todd, Krejsa, Cecile, Rothbaum, Wayne P., Bubnoff, Nikolas, Khandanpour, Cyrus
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection
Yoshida, Hiroki, Hamano, Shinjiro, Senaldi, Giorgio, Covey, Todd, Faggioni, Raffaella, Mu, Sharon, Xia, Min, Wakeham, Andrew C, Nishina, Hiroshi, Potter, Julia, Saris, Chris J.M, Mak, Tak W
Published in Immunity (Cambridge, Mass.) (01.10.2001)
Published in Immunity (Cambridge, Mass.) (01.10.2001)
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1071 SINGLE CELL NETWORK PROFILING (SCNP) ASSAY APPLICATION TO BLADDER CANCER SAMPLES IDENTIFYING RARE EGF RESPONSIVE EPITHELIAL CANCER CELLS SENSITIVE TO PI3K INHIBITION FROM BLADDER WASHINGS
Okhunov, Zhamshid, Covey, Todd M, Gulrajani, Michael, Levey, Helen, Cholankeril, Michelle, Marimpietri, Carol, Fields, Scott, Cesano, Alessandra, Vira, Manish
Published in The Journal of urology (01.04.2012)
Published in The Journal of urology (01.04.2012)
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Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia
Rosen, David B, Putta, Santosh, Covey, Todd, Huang, Ying-Wen, Nolan, Garry P, Cesano, Alessandra, Minden, Mark D, Fantl, Wendy J
Published in PloS one (25.08.2010)
Published in PloS one (25.08.2010)
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Journal Article
Single cell network profiling assay in bladder cancer
Covey, Todd M., Vira, Manish A., Westfall, Matt, Gulrajani, Michael, Cholankeril, Michelle, Okhunov, Zhamshid, Levey, Helen R., Marimpietri, Carol, Hawtin, Rachael, Fields, Scott Z., Cesano, Alessandra
Published in Cytometry. Part A (01.04.2013)
Published in Cytometry. Part A (01.04.2013)
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Journal Article
Single-cell network profiling (SCNP) by flow cytometry in autoimmune disease
Covey, Todd M., Cesano, Alessandra, Parkinson, David R.
Published in Autoimmunity (Chur, Switzerland) (01.11.2010)
Published in Autoimmunity (Chur, Switzerland) (01.11.2010)
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Journal Article
Single cell network profiling (SCNP): mapping drug and target interactions
Covey, Todd M, Putta, Santosh, Cesano, Alessandra
Published in Assay and drug development technologies (01.06.2010)
Published in Assay and drug development technologies (01.06.2010)
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Journal Article
Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile
Barf, Tjeerd, Covey, Todd, Izumi, Raquel, van de Kar, Bas, Gulrajani, Michael, van Lith, Bart, van Hoek, Maaike, de Zwart, Edwin, Mittag, Diana, Demont, Dennis, Verkaik, Saskia, Krantz, Fanny, Pearson, Paul G, Ulrich, Roger, Kaptein, Allard
Published in The Journal of pharmacology and experimental therapeutics (01.11.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2017)
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Journal Article
Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results
Byrd, John C., Wierda, William G., Schuh, Anna, Devereux, Stephen, Chaves, Jorge M., Brown, Jennifer R., Hillmen, Peter, Martin, Peter, Awan, Farrukh T., Stephens, Deborah M., Ghia, Paolo, Barrientos, Jacqueline, Pagel, John M., Woyach, Jennifer A., Burke, Kathleen, Covey, Todd, Gulrajani, Michael, Hamdy, Ahmed, Izumi, Raquel, Frigault, Melanie M., Patel, Priti, Rothbaum, Wayne, Wang, Min Hui, O'Brien, Susan, Furman, Richard R.
Published in Blood (09.04.2020)
Published in Blood (09.04.2020)
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Journal Article
Ibrutinib, but not acalabrutinib, inhibits anti-lymphoma T cell and NK cell function
Hammerich, Linda, Svensson-Arvelund, Judit, Covey, Todd, Brody, Joshua
Published in The Journal of immunology (1950) (01.05.2019)
Published in The Journal of immunology (1950) (01.05.2019)
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