Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5
Clement-Lacroix, P., Little, C.B., Smith, M.M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Lepescheux, L., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Osteoarthritis and cartilage (01.02.2022)
Published in Osteoarthritis and cartilage (01.02.2022)
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OP0258 Efficacy of the highly selective adamts-5 inhibitor glpg1972 in the rat meniscectomy model
Lepescheux, L., Clement-Lacroix, P., Merciris, D., Meurisse, S., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Annals of the rheumatic diseases (01.06.2018)
Published in Annals of the rheumatic diseases (01.06.2018)
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Journal Article
GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA
Clement-Lacroix, P, Little, C, Meurisse, S, Blanqué, R, Mollat, P, Brebion, F, Gosmini, R, De Ceuninck, F, Botez, I, Lepescheux, L, van der Aar, E, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D
Published in Osteoarthritis and cartilage (01.04.2017)
Published in Osteoarthritis and cartilage (01.04.2017)
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AB0144 PHARMACOLOGICAL CHARACTERIZATION OF GLPG3667, A SELECTIVE TYK2 INHIBITOR, SUPPORTS DEVELOPMENT IN DERMATOMYOSITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS
Aggarwal, R, Morand, E F, Blanque, R, Shoji, K, Jans, M, Marsais, F, Furio, L, Colli, M, Lavazais, S, Cottereaux, C, David, C, Houvenaghel, N, Parent, I, Lagoutte, E, Van de Water, A, Perret, L, Alves, S, Amantini, D, Van der Plas, S, Galien, R
Published in Annals of the rheumatic diseases (01.06.2023)
Published in Annals of the rheumatic diseases (01.06.2023)
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Journal Article
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases
Lavazais, Stéphanie, Jargosch, Manja, Dupont, Sonia, Labéguère, Frédéric, Menet, Christel, Jagerschmidt, Catherine, Ohm, Frenz, Kupcsik, Laszlo, Parent, Isabelle, Cottereaux, Céline, Marsais, Florence, Oste, Line, Van de Water, An, Christophe, Thierry, De Vos, Steve, Fallon, Padraic, Lauffer, Felix, Clément-Lacroix, Philippe, Eyerich, Kilian, Brys, Reginald
Published in Science translational medicine (15.02.2023)
Published in Science translational medicine (15.02.2023)
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ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model
Clement-Lacroix, P., Meurisse, S., Lepescheux, L., Merciris, D., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Christophe, T., van der Aar, E.E., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Osteoarthritis and cartilage (01.04.2018)
Published in Osteoarthritis and cartilage (01.04.2018)
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Journal Article
OP0180 Pharmacological characterization of the ADAMTS-5 inhibitor GLPG1972: an oral anti-catabolic agent for the treatment of osteoarthritis
Clement-Lacroix, P, Little, C, Blanqué, R, Meurisse, S, Mollat, P, Brebion, F, Gosmini, R, Ceuninck, F De, Botez, I, Lepescheux, L, Aar, E van der, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D
Published in Annals of the rheumatic diseases (01.06.2017)
Published in Annals of the rheumatic diseases (01.06.2017)
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B110 NOVEL THERAPIES AND TARGETS IN FIBROSIS: Pharmacological Profile And Efficacy Of Glpg1690, A Novel Autotaxin Inhibitor For The treatment Of Idiopathic Pulmonary Fibrosis
Van Der Aar, E M, Heckmann, B, Blanque, R, Desroy, N, Dupont, S, Cottereaux, C, Monjardet, A, Wakselman, E, Dirven, D, Christophe, T, Hrvacic, B, Ralic, J, Marsais, F, Brys, R
Published in American journal of respiratory and critical care medicine (01.01.2016)
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Published in American journal of respiratory and critical care medicine (01.01.2016)
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Effects of SK&F 86002 on cytokine-stimulated IL6 production in cultured neonatal mouse calvaria and SaOS2 osteoblastic cells: the role of prostaglandins and other mechanisms of action
Blanque, R, Cottereaux, C, Gardner, C R
Published in Drugs under experimental and clinical research (1997)
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Published in Drugs under experimental and clinical research (1997)
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