Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α‑Mannose as Adjuvants
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Published in Bioconjugate chemistry (20.11.2019)
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Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Hayashi, Tomoko, Yao, Shiyin, Crain, Brian, Promessi, Victor J, Shyu, Luke, Sheng, Caroline, Kang, McNancy, Cottam, Howard B, Carson, Dennis A, Corr, Maripat
Published in PloS one (15.06.2015)
Published in PloS one (15.06.2015)
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Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides
Shinchi, Hiroyuki, Crain, Brian, Yao, Shiyin, Chan, Michael, Zhang, Shannon S, Ahmadiiveli, Alast, Suda, Yasuo, Hayashi, Tomoko, Cottam, Howard B, Carson, Dennis A
Published in Bioconjugate chemistry (19.08.2015)
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Published in Blood (15.01.2007)
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Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
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Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection
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Published in Proceedings of the National Academy of Sciences - PNAS (08.06.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (08.06.2021)
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Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects
Shinchi, Hiroyuki, Komaki, Fumikazu, Yuki, Masaharu, Ohara, Haruka, Hayakawa, Naohiro, Wakao, Masahiro, Cottam, Howard B, Hayashi, Tomoko, Carson, Dennis A, Moroishi, Toshiro, Suda, Yasuo
Published in ACS chemical biology (15.04.2022)
Published in ACS chemical biology (15.04.2022)
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Identification of Substituted Pyrimido[5,4‑b]indoles as Selective Toll-Like Receptor 4 Ligands
Chan, Michael, Hayashi, Tomoko, Mathewson, Richard D, Nour, Afshin, Hayashi, Yuki, Yao, Shiyin, Tawatao, Rommel I, Crain, Brian, Tsigelny, Igor F, Kouznetsova, Valentina L, Messer, Karen, Pu, Minya, Corr, Maripat, Carson, Dennis A, Cottam, Howard B
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Wu, Raymond P., Hayashi, Tomoko, Cottam, Howard B., Jin, Guangyi, Yao, Shiyin, Wu, Christina C. N., Rosenbach, Michael D., Corr, Maripat, Schwab, Richard B., Carson, Dennis A.
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
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Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands
Baba, Akihito, Wakao, Masahiro, Shinchi, Hiroyuki, Chan, Michael, Hayashi, Tomoko, Yao, Shiyin, Cottam, Howard B., Carson, Dennis A., Suda, Yasuo
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
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Molecular Basis for the Immunostimulatory Activity of Guanine Nucleoside Analogs: Activation of Toll-like Receptor 7
Lee, Jongdae, Chuang, Tsung-Hsien, Redecke, Vanessa, She, Liping, Pitha, Paula M., Carson, Dennis A., Raz, Eyal, Cottam, Howard B.
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (27.05.2003)
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Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release
Shpigelman, Jonathan, Lao, Fitzgerald S, Yao, Shiyin, Li, Chenyang, Saito, Tetsuya, Sato-Kaneko, Fumi, Nolan, John P, Shukla, Nikunj M, Pu, Minya, Messer, Karen, Cottam, Howard B, Carson, Dennis A, Corr, Maripat, Hayashi, Tomoko
Published in Frontiers in pharmacology (16.04.2021)
Published in Frontiers in pharmacology (16.04.2021)
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Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice
Goff, Peter H, Hayashi, Tomoko, He, Wenqian, Yao, Shiyin, Cottam, Howard B, Tan, Gene S, Crain, Brian, Krammer, Florian, Messer, Karen, Pu, Minya, Carson, Dennis A, Palese, Peter, Corr, Maripat
Published in Journal of virology (01.10.2017)
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A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity
Sato-Kaneko, Fumi, Yao, Shiyin, Lao, Fitzgerald S, Shpigelman, Jonathan, Messer, Karen, Pu, Minya, Shukla, Nikunj M, Cottam, Howard B, Chan, Michael, Chu, Paul J, Burkhart, David, Schoener, Roman, Matsutani, Takaji, Carson, Dennis A, Corr, Maripat, Hayashi, Tomoko
Published in Frontiers in immunology (19.06.2020)
Published in Frontiers in immunology (19.06.2020)
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Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx
Sako, Yukiya, Sato-Kaneko, Fumi, Shukla, Nikunj M., Yao, Shiyin, Belsuzarri, Masiel M., Chan, Michael, Saito, Tetsuya, Lao, Fitzgerald S., Kong, Helen, Puffer, Marina, Messer, Karen, Pu, Minya, Cottam, Howard B., Carson, Dennis A., Hayashi, Tomoko
Published in ACS chemical biology (21.04.2023)
Published in ACS chemical biology (21.04.2023)
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Structure–Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli
Chan, Michael, Lao, Fitzgerald S, Chu, Paul J, Shpigelman, Jonathan, Yao, Shiyin, Nan, Jason, Sato-Kaneko, Fumi, Li, Vicky, Hayashi, Tomoko, Corr, Maripat, Carson, Dennis A, Cottam, Howard B, Shukla, Nikunj M
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses
Abdelwahab, Walid M, Auclair, Sarah, Borgogna, Timothy, Siram, Karthik, Riffey, Alexander, Bazin, Hélène G, Cottam, Howard B, Hayashi, Tomoko, Evans, Jay T, Burkhart, David J
Published in Pharmaceutics (01.01.2024)
Published in Pharmaceutics (01.01.2024)
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Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation
Shukla, Nikunj M., Chan, Michael, Lao, Fitzgerald S., Chu, Paul J., Belsuzarri, Masiel, Yao, Shiyin, Nan, Jason, Sato-Kaneko, Fumi, Saito, Tetsuya, Hayashi, Tomoko, Corr, Maripat, Carson, Dennis A., Cottam, Howard B.
Published in Bioorganic & medicinal chemistry (01.08.2021)
Published in Bioorganic & medicinal chemistry (01.08.2021)
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