Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy
Long, Kimberly K, O'Shea, Karen M, Khairallah, Ramzi J, Howell, Kelly, Paushkin, Sergey, Chen, Karen S, Cote, Shaun M, Webster, Micah T, Stains, Joseph P, Treece, Erin, Buckler, Alan, Donovan, Adriana
Published in Human molecular genetics (01.04.2019)
Published in Human molecular genetics (01.04.2019)
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Journal Article
A Randomized Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular Atrophy
Barrett, Doreen, Bilic, Sanela, Chyung, Yung, Cote, Shaun M., Iarrobino, Ryan, Kacena, Katherine, Kalra, Ashish, Long, Kimberly, Nomikos, George, Place, Amy, Still, James Gordon, Vrishabhendra, Leela
Published in Advances in therapy (01.06.2021)
Published in Advances in therapy (01.06.2021)
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Preclinical Safety Assessment and Toxicokinetics of Apitegromab, an Antibody Targeting Proforms of Myostatin for the Treatment of Muscle-Atrophying Disease
Welsh, Brian T., Cote, Shaun M., Meshulam, Deborah, Jackson, Justin, Pal, Ajai, Lansita, Janice, Kalra, Ashish
Published in International journal of toxicology (01.07.2021)
Published in International journal of toxicology (01.07.2021)
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Journal Article
Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator/IKKβ Protein–Protein Interface
Golden, Mary S, Cote, Shaun M, Sayeg, Marianna, Zerbe, Brandon S, Villar, Elizabeth A, Beglov, Dmitri, Sazinsky, Stephen L, Georgiadis, Rosina M, Vajda, Sandor, Kozakov, Dima, Whitty, Adrian
Published in Journal of the American Chemical Society (24.04.2013)
Published in Journal of the American Chemical Society (24.04.2013)
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Journal Article
A Sensitive and Selective Immunoassay for the Quantitation of Serum Latent Myostatin after In Vivo Administration of SRK-015, a Selective Inhibitor of Myostatin Activation
Cote, Shaun M., Jackson, Justin, Pirruccello-Straub, Michelle, Carven, Gregory J., Wawersik, Stefan
Published in SLAS discovery (01.01.2020)
Published in SLAS discovery (01.01.2020)
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Journal Article
Mutation of Nonessential Cysteines Shows That the NF-κB Essential Modulator Forms a Constitutive Noncovalent Dimer That Binds IκB Kinase‑β with High Affinity
Cote, Shaun M, Gilmore, Thomas D, Shaffer, Robert, Weber, Urs, Bollam, Rishitha, Golden, Mary S, Glover, Kimberley, Herscovitch, Melanie, Ennis, Thomas, Allen, Karen N, Whitty, Adrian
Published in Biochemistry (Easton) (23.12.2013)
Published in Biochemistry (Easton) (23.12.2013)
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Journal Article
Selective Inhibition of Repulsive Guidance Molecule C/Hemojuvelin (RGMc/HJV) with SRK-256 to Mobilize Iron in Functional Iron Deficiency
Cortes, Leslie K., Nicholls, Samantha B., Streich, Frederick C., Boston, Chris, Pal, Ajai, Regmi, Bimal, Cote, Shaun M., Canonico, Kaleigh, Qatanani, Mo
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Safety and Efficacy of Apitegromab in Patients With Spinal Muscular Atrophy Types 2 and 3: The Phase 2 TOPAZ Study
Crawford, Thomas O, Darras, Basil T, Day, John W, Dunaway Young, Sally, Duong, Tina, Nelson, Leslie L, Barrett, Doreen, Song, Guochen, Bilic, Sanela, Cote, Shaun, Sadanowicz, Mara, Iarrobino, Ryan, Xu, Tiina J, O'Neil, Janet, Rossello, José, Place, Amy, Kertesz, Nathalie, Nomikos, George, Chyung, Yung
Published in Neurology (12.03.2024)
Published in Neurology (12.03.2024)
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Journal Article
Relationship of pharmacokinetics and pharmacodynamics to apitegromab efficacy in patients with later-onset spinal muscular atrophy (Types 2 and 3 SMA): Results from the TOPAZ study
Crawford, Thomas, Place, Amy, Barrett, Doreen, Cote, Shaun, Nomikos, George, Song, Guochen, Bilic, Sanela, Kalra, Ashish, Sadanowicz, Mara, O'Neil, Janet, Iarrobino, Ryan, Kertesz, Nathalie, Chyung, Yung
Published in Journal of the neurological sciences (01.10.2021)
Published in Journal of the neurological sciences (01.10.2021)
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Journal Article
Mutation of Non-Essential Cysteines Shows that NF-κB Essential Modulator (NEMO) Forms a Constitutive Noncovalent Dimer that Binds IκB Kinase-β (IKKβ) with High Affinity
Cote, Shaun M., Gilmore, Thomas D., Shaffer, Robert, Weber, Urs, Bollam, Rishitha, Golden, Mary S., Glover, Kimberley, Herscovitch, Melanie, Ennis, Thomas, Allen, Karen N., Whitty, Adrian
Published in Biochemistry (Easton) (10.12.2013)
Published in Biochemistry (Easton) (10.12.2013)
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Journal Article
SELECTIVE AND POTENT INHIBITORY ANTIBODIES OF MYOSTATIN ACTIVATION
CHAPRON, Christopher, HUANG, Yan, CANONICO, Kaleigh, COTE, Shaun M, JACKSON, Justin William, DANEHY JR., Francis, STREICH JR., Frederick C, KUMAR, Sandeep, KAVOSI, Mania, FULHAM, Melissa
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
Mutation of Nonessential Cysteines Shows That the NF-B Essential Modulator Forms a Constitutive Noncovalent Dimer That Binds IB Kinase- with High Affinity
Cote, Shaun M, Gilmore Thomas D.author, Shaffer Robertauthor, Weber Ursauthor, Bollam Rishithaauthor, Golden Mary S.author, Glover Kimberleyauthor, Herscovitch Melanieauthor, Ennis Thomasauthor, Allen Karen N.author, Whitty Adrianauthor
Year of Publication 2015
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Year of Publication 2015
Journal Article
Binding Efficiency of ProteinProtein Complexes
Day, Eric S, Cote Shaun M.authorDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States, Whitty AdrianauthorDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States
Year of Publication 2015
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Year of Publication 2015
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