Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting σ1 receptors produce anti-cocaine effects in mice
MATSUMOTO, Rae R, MCCRACKEN, Kari A, FRIEDMAN, Michele J, POUW, Buddy, DE COSTA, Brian R, BOWEN, Wayne D
Published in European journal of pharmacology (01.05.2001)
Published in European journal of pharmacology (01.05.2001)
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Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the .sigma. receptor
De Costa, Brian R, Radesca, Lilian, Di Paolo, Lisa, Bowen, Wayne D
Published in Journal of medicinal chemistry (01.01.1992)
Published in Journal of medicinal chemistry (01.01.1992)
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N-alkyl substituted analogs of the σ receptor ligand BD1008 and traditional σ receptor ligands affect cocaine-induced convulsions and lethality in mice
Matsumoto, Rae R., McCracken, Kari A., Pouw, Buddy, Miller, Jeffrey, Bowen, Wayne D., Williams, Wanda, De Costa, Brian R.
Published in European journal of pharmacology (12.01.2001)
Published in European journal of pharmacology (12.01.2001)
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Synthesis and receptor binding of enantiomeric N-substituted cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamines as high-affinity .sigma. receptor ligands
Radesca, Lilian, Bowen, Wayne D, Di Paolo, Lisa, De Costa, Brian R
Published in Journal of medicinal chemistry (01.10.1991)
Published in Journal of medicinal chemistry (01.10.1991)
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Subchronic administration of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine (BD1047) alters σ1 receptor binding
ZAMBON, A. C, DE COSTA, B. R, KANTHASAMY, A. G, NGUYEN, B. J. Q. H, MATSUMOTO, R. R
Published in European journal of pharmacology (01.04.1997)
Published in European journal of pharmacology (01.04.1997)
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Synthesis and Transporter Binding Properties of Bridged Piperazine Analogues of 1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine (GBR 12909)
Zhang, Ying, Rothman, Richard B, Dersch, Christina M, de Costa, Brian R, Jacobson, Arthur E, Rice, Kenner C
Published in Journal of medicinal chemistry (14.12.2000)
Published in Journal of medicinal chemistry (14.12.2000)
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A new approach to the design of .sigma.-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine-related polyamines at .sigma.-1 and .sigma.-2 receptor subtypes
de Costa, Brian R, He, Xiao-shu, Dominguez, Celia, Cutts, Janet, Williams, Wanda, Bowen, Wayne D
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909)
Matecka, Dorota, Rothman, Richard B, Radesca, Lilian, de Costa, Brian R, Dersch, Christina M, Partilla, John S, Pert, Agu, Glowa, John R, Wojnicki, Francis H. E, Rice, Kenner C
Published in Journal of medicinal chemistry (22.11.1996)
Published in Journal of medicinal chemistry (22.11.1996)
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Apparent down-regulation of rat brain mu- and kappa-opioid binding sites labelled with [3H]cycloFOXY following chronic administration of the potent 5-hydroxytryptamine reuptake blocker, clomipramine
Benkelfat, C, Aulakh, C S, Bykov, V, Rice, K C, De Costa, B R, Rothman, R B
Published in Journal of pharmacy and pharmacology (01.12.1989)
Published in Journal of pharmacy and pharmacology (01.12.1989)
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Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors
Gu, Zi Qiang, Wong, Garry, Dominguez, Celia, de Costa, Brian R, Rice, Kenner C, Skolnick, Phil
Published in Journal of medicinal chemistry (16.04.1993)
Published in Journal of medicinal chemistry (16.04.1993)
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Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain
Rothman, Richard B, Bykov, Victor, de Costa, Brian R, Jacobson, Arthur E, Rice, Kenner C, Brady, Linda S
Published in Peptides (New York, N.Y. : 1980) (01.03.1990)
Published in Peptides (New York, N.Y. : 1980) (01.03.1990)
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Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at .sigma. receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds
de Costa, Brian R, He, Xiaoshu, Linders, Joannes T. M, Dominguez, Celia, Gu, Zi Qiang, Williams, Wanda, Bowen, Wayne
Published in Journal of medicinal chemistry (06.08.1993)
Published in Journal of medicinal chemistry (06.08.1993)
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Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediamines as .sigma. receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes
De Costa, Brian R, Dominguez, Celia, He, Xiao Shu, Williams, Wanda, Radesca, Lilian, Bowen, Wayne
Published in Journal of medicinal chemistry (01.11.1992)
Published in Journal of medicinal chemistry (01.11.1992)
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Alterations in the stereochemistry of the .kappa.-selective opioid agonist U50,488 result in high-affinity .sigma. ligands
De Costa, Brian R, Bowen, Wayne D, Hellewell, Susan B, George, Clifford, Rothman, Richard B, Reid, Audrey A, Walker, J. Michael, Jacobson, Arthur E, Rice, Kenner C
Published in Journal of medicinal chemistry (01.08.1989)
Published in Journal of medicinal chemistry (01.08.1989)
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Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites
He, Xiaoshu, Raymon, Lionel P, Mattson, Mariena V, Eldefrawi, Mohyee E, de Costa, Brian R
Published in Journal of medicinal chemistry (10.12.1993)
Published in Journal of medicinal chemistry (10.12.1993)
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Synthesis and binding characteristics of potential SPECT imaging agents for .sigma.-1 and .sigma.-2 binding sites
He, Xiao Shu, Bowen, Wayne D, Lee, Kan Sam, Williams, Wanda, Weinberger, Daniel R, De Costa, Brian R
Published in Journal of medicinal chemistry (05.03.1993)
Published in Journal of medicinal chemistry (05.03.1993)
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Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity .sigma. receptor ligands. Identification of a new class of highly potent and selective .sigma. receptor probes
De Costa, Brian R, Bowen, Wayne D, Thurkauf, Andrew, Finn, Daniel T, Vazirani, Sondra, Rothman, Richard B, Band, Linda, Contreras, Patricia C, Gray, Nancy M
Published in Journal of medicinal chemistry (01.11.1990)
Published in Journal of medicinal chemistry (01.11.1990)
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