The expanding utility of continuous flow hydrogenation
Cossar, Peter J, Hizartzidis, Lacey, Simone, Michela I, McCluskey, Adam, Gordon, Christopher P
Published in Organic & biomolecular chemistry (14.07.2015)
Published in Organic & biomolecular chemistry (14.07.2015)
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Journal Article
Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry
Verhoef, Carlo J. A, Kay, Danielle F, van Dijck, Lars, Doveston, Richard G, Brunsveld, Luc, Leney, Aneika C, Cossar, Peter J
Published in Chemical science (Cambridge) (21.06.2023)
Published in Chemical science (Cambridge) (21.06.2023)
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Journal Article
Amino Alcohols as Potential Antibiotic and Antifungal Leads
Baker, Jennifer R, Cossar, Peter J, Blaskovich, Mark A T, Elliott, Alysha G, Zuegg, Johannes, Cooper, Matthew A, Lewis, Peter J, McCluskey, Adam
Published in Molecules (Basel, Switzerland) (22.03.2022)
Published in Molecules (Basel, Switzerland) (22.03.2022)
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Journal Article
Mapping the cortical representation of the lumbar paravertebral muscles
O’Connell, N.E, Maskill, D.W, Cossar, J, Nowicky, A.V
Published in Clinical neurophysiology (01.11.2007)
Published in Clinical neurophysiology (01.11.2007)
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Journal Article
Protein‐protein interactions as antibiotic targets: A medicinal chemistry perspective
Cossar, Peter J., Lewis, Peter J., McCluskey, Adam
Published in Medicinal research reviews (01.03.2020)
Published in Medicinal research reviews (01.03.2020)
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Journal Article
Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering
Wolter, Madita, Valenti, Dario, Cossar, Peter J., Levy, Laura M., Hristeva, Stanimira, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian
Published in Angewandte Chemie International Edition (23.11.2020)
Published in Angewandte Chemie International Edition (23.11.2020)
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Journal Article
Small-Molecule Inhibitors of the NusB–NusE Protein–Protein Interaction with Antibiotic Activity
Cossar, Peter J, Abdel-Hamid, Mohammed K, Ma, Cong, Sakoff, Jennette A, Trinh, Trieu N, Gordon, Christopher P, Lewis, Peter J, McCluskey, Adam
Published in ACS omega (31.07.2017)
Published in ACS omega (31.07.2017)
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Journal Article
Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3‑3 Hub Protein Interactions
Cossar, Peter J, Wolter, Madita, van Dijck, Lars, Valenti, Dario, Levy, Laura M, Ottmann, Christian, Brunsveld, Luc
Published in Journal of the American Chemical Society (09.06.2021)
Published in Journal of the American Chemical Society (09.06.2021)
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Journal Article
Discovery of 14‐3‐3 PPI Stabilizers by Extension of an Amidine‐Substituted Thiophene Fragment
Wu, Qi, Centorrino, Federica, Guillory, Xavier, Wolter, Madita, Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Published in Chembiochem : a European journal of chemical biology (02.01.2024)
Published in Chembiochem : a European journal of chemical biology (02.01.2024)
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Journal Article
An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3‑3 Interaction with NF-κBUtilizing a Reversible Covalent Tethering Approach
Wolter, Madita, Valenti, Dario, Cossar, Peter J, Hristeva, Stanimira, Levy, Laura M, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian
Published in Journal of medicinal chemistry (24.06.2021)
Published in Journal of medicinal chemistry (24.06.2021)
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Journal Article
14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization
Somsen, Bente A., Cossar, Peter J., Arkin, Michelle R., Brunsveld, Luc, Ottmann, Christian
Published in Chembiochem : a European journal of chemical biology (15.07.2024)
Published in Chembiochem : a European journal of chemical biology (15.07.2024)
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Journal Article
Covalent flexible peptide docking in Rosetta
Tivon, Barr, Gabizon, Ronen, Somsen, Bente A, Cossar, Peter J, Ottmann, Christian, London, Nir
Published in Chemical science (Cambridge) (18.08.2021)
Published in Chemical science (Cambridge) (18.08.2021)
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Journal Article
Heterologous biopharmaceutical protein expression in Streptomyces
Binnie, Craig, Douglas Cossar, J., Stewart, Donald I.H.
Published in Trends in biotechnology (Regular ed.) (01.08.1997)
Published in Trends in biotechnology (Regular ed.) (01.08.1997)
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Journal Article
Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex
Somsen, Bente A., Sijbesma, Eline, Leysen, Seppe, Honzejkova, Karolina, Visser, Emira J., Cossar, Peter J., Obšil, Tomáš, Brunsveld, Luc, Ottmann, Christian
Published in The Journal of biological chemistry (01.07.2023)
Published in The Journal of biological chemistry (01.07.2023)
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Journal Article
Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach
Somsen, Bente A., Schellekens, Rick J.C., Verhoef, Carlo J.A., Arkin, Michelle R., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Published in Journal of the American Chemical Society (29.03.2023)
Published in Journal of the American Chemical Society (29.03.2023)
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Journal Article
3,5-Bis(trifluoromethyl)phenylsulfonamides, a novel pancreatic cancer active lead. Investigation of the terminal aromatic moiety
Sun, Jufeng, Ambrus, Joey I., Baker, Jennifer R., Russell, Cecilia C., Cossar, Peter J., Sakoff, Jennette A., Scarlett, Christopher J., McCluskey, Adam
Published in Bioorganic & medicinal chemistry letters (01.04.2022)
Published in Bioorganic & medicinal chemistry letters (01.04.2022)
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Journal Article