Metabolic gatekeeper function of B-lymphoid transcription factors
Chan, Lai N., Chen, Zhengshan, Braas, Daniel, Lee, Jae-Woong, Xiao, Gang, Geng, Huimin, Cosgun, Kadriye Nehir, Hurtz, Christian, Shojaee, Seyedmehdi, Cazzaniga, Valeria, Schjerven, Hilde, Ernst, Thomas, Hochhaus, Andreas, Kornblau, Steven M., Konopleva, Marina, Pufall, Miles A., Cazzaniga, Giovanni, Liu, Grace J., Milne, Thomas A., Koeffler, H. Phillip, Ross, Theodora S., Sánchez-García, Isidro, Borkhardt, Arndt, Yamamoto, Keith R., Dickins, Ross A., Graeber, Thomas G., Müschen, Markus
Published in Nature (London) (23.02.2017)
Published in Nature (London) (23.02.2017)
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Journal Article
Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier
Cosgun, Kadriye Nehir, Rahmig, Susann, Mende, Nicole, Reinke, Sören, Hauber, Ilona, Schäfer, Carola, Petzold, Anke, Weisbach, Henry, Heidkamp, Gordon, Purbojo, Ariawan, Cesnjevar, Robert, Platz, Alexander, Bornhäuser, Martin, Schmitz, Marc, Dudziak, Diana, Hauber, Joachim, Kirberg, Jörg, Waskow, Claudia
Published in Cell stem cell (07.08.2014)
Published in Cell stem cell (07.08.2014)
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Journal Article
Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells
Grinenko, Tatyana, Arndt, Kathrin, Portz, Melanie, Mende, Nicole, Günther, Marko, Cosgun, Kadriye Nehir, Alexopoulou, Dimitra, Lakshmanaperumal, Naharajan, Henry, Ian, Dahl, Andreas, Waskow, Claudia
Published in The Journal of experimental medicine (10.02.2014)
Published in The Journal of experimental medicine (10.02.2014)
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Journal Article
In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemia in NSG mice
von Bonin, Malte, Wermke, Martin, Cosgun, Kadriye Nehir, Thiede, Christian, Bornhauser, Martin, Wagemaker, Gerard, Waskow, Claudia
Published in PloS one (09.04.2013)
Published in PloS one (09.04.2013)
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Journal Article
CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies
Lee, Jae-Woong, Geng, Huimin, Chen, Zhengshan, Klemm, Lars, Cosgun, Kadriye Nehir, Xiao, Gang, Masouleh, Behzad, Hurtz, Christian, Parekh, Samir, Kornblau, Steven M., Melnick, Ari, Abbas, Abul, Paietta, Elisabeth, Müschen, Markus
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV
Daenthanasanmak, Anusara, Salguero, Gustavo, Sundarasetty, Bala Sai, Waskow, Claudia, Cosgun, Kadriye Nehir, Guzman, Carlos A, Riese, Peggy, Gerasch, Laura, Schneider, Andreas, Ingendoh, Alexandra, Messerle, Martin, Gabaev, Ildar, Woelk, Benno, Ruggiero, Eliana, Schmidt, Manfred, von Kalle, Christof, Figueiredo, Constanca, Eiz-Vesper, Britta, von Kaisenberg, Constantin, Ganser, Arnold, Stripecke, Renata
Published in Molecular therapy. Methods & clinical development (01.01.2015)
Published in Molecular therapy. Methods & clinical development (01.01.2015)
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Journal Article
Immunoglobulin Light Chains Control Permissiveness to Malignant B-Cell Transformation By RAS-Pathway Lesions
Chan, Lai N, Kume, Kohei, Hurtz, Christian, Robinson, Mark E, Cosgun, Kadriye Nehir, Müschen, Markus
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies
Ketzer, Franz, Klemm, Lars, Robinson, Mark E, Loucks, Christian, Arce, David Fonseca, Cosgun, Kadriye Nehir, Kothari, Shalin, Müschen, Markus
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell Transformation
Chan, Lai N., Robinson, Mark E., Cosgun, Kadriye Nehir, Yu, Xiaohui, Leveille, Etienne, Geng, Huimin, Müschen, Markus
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Xiao, Gang, Chan, Lai N., Klemm, Lars, Braas, Daniel, Chen, Zhengshan, Geng, Huimin, Zhang, Qiuyi Chen, Aghajanirefah, Ali, Cosgun, Kadriye Nehir, Sadras, Teresa, Lee, Jaewoong, Mirzapoiazova, Tamara, Salgia, Ravi, Ernst, Thomas, Hochhaus, Andreas, Jumaa, Hassan, Jiang, Xiaoyan, Weinstock, David M., Graeber, Thomas G., Müschen, Markus
Published in Cell (05.04.2018)
Published in Cell (05.04.2018)
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Journal Article
The Transcriptional Landscape of Ph+B-ALL Is Orchestrated By Long-Range Enhancer-Promoter Interactions and the Coordinated Action of Phosphorylation-Dependent and Phosphorylation-Independent Transcription Factors
Ng, Han Leng, Robinson, Mark E, Malysheva, Valeria, Deniz, Ozgen, Crump, Nicholas, Cosgun, Kadriye Nehir, Helian, Kaiyue, Spivakov, Mikhail, Müschen, Markus, Feldhahn, Niklas
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies
Kume, Kohei, Lee, Jaewoong, Cheng, Zhangliang, Robinson, Mark E, Leveille, Etienne, Cosgun, Kadriye Nehir, Chan, Lai N, Feng, Yanzhi, Arce, David Fonseca, Khanduja, Dhruv, Toomre, Derek, Müschen, Markus
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia
Kume, Kohei, Chen, Zhengshan, Robinson, Mark E, Chan, Lai N, Leveille, Etienne, Cosgun, Kadriye Nehir, Cheng, Zhangliang, Arce, David Fonseca, Khanduja, Dhruv, Graeber, Thomas, Müschen, Markus
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Computational Discovery and Validation of NAD+ Biosynthesis As Unique Vulnerability in B-Lymphoid Malignancies
Li, Qin, Robinson, Mark E, Leveille, Etienne, Zhang, Chang, Sun, Ruifeng, Cheng, Zhangliang, Kume, Kohei, Cosgun, Kadriye Nehir, Kothari, Shalin, Khanduja, Dhruv, Nakada, Daisuke, Müschen, Markus
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Identification of BCL6 As Synthetic Lethality in RAS-Driven B-Cell Transformation
Chan, Lai N., Hurtz, Christian, Leveille, Etienne, Kume, Kohei, Robinson, Mark E., Geng, Huimin, Cosgun, Kadriye Nehir, Müschen, Markus
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Pharmacological Targeting of PI3K-Dependent Central Tolerance Mechanisms in Refractory Pre-Germinal Center B-Cell Malignancies
Kume, Kohei, Lee, Jaewoong, Chan, Lai N., Robinson, Mark E., Cosgun, Kadriye Nehir, Meffre, Eric, Müschen, Markus
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
β-catenin engages IKZF factors to control lymphopoiesis
Cosgun, Kadriye Nehir, Jumaa, Huda, Robinson, Mark E., Xu, Liang, Xiao, Gang, Arce, David Fonseca, Khanduja, Dhruv, Chan, Lai N., Lee, Jaewoong, Schjerven, Hilde, Jellusova, Julia, Müschen, Markus
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
Repressive β-Catenin-Ikaros Complexes Are Essential to Prevent Clonal Evolution of Human Lymphopoiesis
Cosgun, Kadriye Nehir, Liu, Wei, Robinson, Mark E., Fonseca Arce, David, VanOudenhove, Jennifer, Bigogno, Alberto, Flavell, Richard, Halene, Stephanie, Müschen, Markus
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies
Kume, Kohei, Chen, Zhengshan, Chan, Lai N., Robinson, Mark E., Leveille, Etienne, Lee, Jaewoong, Cosgun, Kadriye Nehir, Fonseca Arce, David, Khanduja, Dhruv, Klemm, Lars, Müschen, Markus
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies
Cosgun, Kadriye Nehir, Jumaa, Huda, Robinson, Mark E., Chan, Lai N., Lee, Jaewoong, Kume, Kohei, Fonseca Arce, David, Jellusova, Julia, Müschen, Markus
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article