Search Results - "Cosenza, Stephen C." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

by Athuluri-Divakar, Sai Krishna, Vasquez-Del Carpio, Rodrigo, Dutta, Kaushik, Baker, Stacey J., Cosenza, Stephen C., Basu, Indranil, Gupta, Yogesh K., Reddy, M.V. Ramana, Ueno, Lynn, Hart, Jonathan R., Vogt, Peter K., Mulholland, David, Guha, Chandan, Aggarwal, Aneel K., Reddy, E. Premkumar
Published in Cell (21.04.2016)

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Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease

Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease

by Sato, Katsutoshi, Padgaonkar, Amol A, Baker, Stacey J, Cosenza, Stephen C, Rechkoblit, Olga, Subbaiah, D R C Venkata, Domingo-Domenech, Josep, Bartkowski, Alison, Port, Elisa R, Aggarwal, Aneel K, Ramana Reddy, M V, Irie, Hanna Y, Reddy, E Premkumar
Published in Nature communications (03.08.2021)

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Discovery of a Clinical Stage Multi-Kinase Inhibitor Sodium (E)-2-{2-Methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): Synthesis, Structure–Activity Relationship, and Biological Activity

Discovery of a Clinical Stage Multi-Kinase Inhibitor Sodium (E)-2-{2-Methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): Synthesis, Structure–Activity Relationship, and Biological Activity

by Reddy, M. V. Ramana, Venkatapuram, Padmavathi, Mallireddigari, Muralidhar R, Pallela, Venkat R, Cosenza, Stephen C, Robell, Kimberly A, Akula, Balaiah, Hoffman, Benjamin S, Reddy, E. Premkumar
Published in Journal of medicinal chemistry (22.09.2011)

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ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent

by Gumireddy, Kiranmai, Reddy, M.V. Ramana, Cosenza, Stephen C., Nathan, R. Boomi, Baker, Stacey J., Papathi, Nabisa, Jiang, Jiandong, Holland, James, Reddy, E. Premkumar
Published in Cancer cell (01.03.2005)

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ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway

ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway

by Kang, Anthony D, Cosenza, Stephen C, Bonagura, Marie, Manair, Manoj, Reddy, M V Ramana, Reddy, E Premkumar
Published in PloS one (07.03.2013)

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A Non-ATP-Competitive Inhibitor of BCR-ABL Overrides Imatinib Resistance

A Non-ATP-Competitive Inhibitor of BCR-ABL Overrides Imatinib Resistance

by Gumireddy, Kiranmai, Baker, Stacey J., Cosenza, Stephen C., John, Premila, Kang, Anthony D., Robell, Kimberly A., M. V. Ramana Reddy, Reddy, E. Premkumar, Vogt, Peter K.
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2005)

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Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent

Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent

by Chun, Amy W., Cosenza, Stephen C., Taft, David R., Maniar, Manoj
Published in Cancer chemotherapy and pharmacology (01.12.2009)

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A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent

A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent

by Baker, Stacey J., Cosenza, Stephen C., Athuluri-Divakar, Saikrishna, Reddy, M.V. Ramana, Vasquez-Del Carpio, Rodrigo, Jain, Rinku, Aggarwal, Aneel K., Reddy, E. Premkumar
Published in Molecular cell (02.07.2020)

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Discovery of 8‑Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3‑d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

Discovery of 8‑Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3‑d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

by Reddy, M. V. Ramana, Akula, Balireddy, Cosenza, Stephen C, Athuluridivakar, Saikrishna, Mallireddigari, Muralidhar R, Pallela, Venkat R, Billa, Vinay K, Subbaiah, D. R. C. Venkata, Bharathi, E. Vijaya, Vasquez-Del Carpio, Rodrigo, Padgaonkar, Amol, Baker, Stacey J, Reddy, E. Premkumar
Published in Journal of medicinal chemistry (13.02.2014)

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Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia

Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia

by Baker, Stacey J, Cosenza, Stephen C, Ramana Reddy, M V, Premkumar Reddy, E
Published in Oncotarget (08.03.2019)

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(Z)-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure–Activity Relationship (SAR), Tubulin Polymerization, and Cell Growth Inhibition Studies

(Z)-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure–Activity Relationship (SAR), Tubulin Polymerization, and Cell Growth Inhibition Studies

by Reddy, M. V. Ramana, Akula, Balaiah, Cosenza, Stephen C, Lee, Clement M, Mallireddigari, Muralidhar R, Pallela, Venkat R, Subbaiah, D. R. C. Venkata, Udofa, Andrew, Reddy, E. Premkumar
Published in Journal of medicinal chemistry (14.06.2012)

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Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia

Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia

by Padgaonkar, Amol, Rechkoblit, Olga, Vasquez-Del Carpio, Rodgrigo, Pallela, Venkat, Venkata Subbaiah, Drc, Cosenza, Stephen C, Baker, Stacey J, Ramana Reddy, M V, Aggarwal, Aneel, Reddy, E Premkumar
Published in Oncotarget (28.12.2018)

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Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)

Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)

by Reddy, M.V. Ramana, Akula, Balireddy, Jatiani, Shashidhar, Vasquez-Del Carpio, Rodrigo, Billa, Vinay K., Mallireddigari, Muralidhar R., Cosenza, Stephen C., Venkata Subbaiah, D.R.C., Bharathi, E. Vijaya, Pallela, Venkat R., Ramkumar, Poornima, Jain, Rinku, Aggarwal, Aneel K., Reddy, E. Premkumar
Published in Bioorganic & medicinal chemistry (15.02.2016)

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Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140

Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140

by Eachkoti, Rafiqa, Reddy, M.V. Ramana, Lieu, Yen K, Cosenza, Stephen C, Reddy, E. PremKumar
Published in European journal of cancer (1990) (01.07.2014)

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Design, Synthesis, and Biological Evaluation of (E)‑N‑Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents

Design, Synthesis, and Biological Evaluation of (E)‑N‑Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents

by Reddy, M. V. Ramana, Mallireddigari, Muralidhar R, Pallela, Venkat R, Cosenza, Stephen C, Billa, Vinay K, Akula, Balaiah, Subbaiah, D. R. C. Venkata, Bharathi, E. Vijaya, Padgaonkar, Amol, Lv, Hua, Gallo, James M, Reddy, E. Premkumar
Published in Journal of medicinal chemistry (11.07.2013)

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Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent

Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent

by Pallela, Venkat R, Mallireddigari, Muralidhar R, Cosenza, Stephen C, Akula, Balaiah, Subbaiah, D R C Venkata, Reddy, E Premkumar, Reddy, M V Ramana
Published in Organic & biomolecular chemistry (28.03.2013)

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Design, Synthesis, and Biological Evaluation of (E)-Styrylbenzylsulfones as Novel Anticancer Agents

Design, Synthesis, and Biological Evaluation of (E)-Styrylbenzylsulfones as Novel Anticancer Agents

by Reddy, M. V. Ramana, Mallireddigari, Muralidhar R, Cosenza, Stephen C, Pallela, Venkat R, Iqbal, Nabisa M, Robell, Kimberly A, Kang, Anthony D, Reddy, E. Premkumar
Published in Journal of medicinal chemistry (10.01.2008)

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Design, synthesis and evaluation of ( E)-α-benzylthio chalcones as novel inhibitors of BCR-ABL kinase

Design, synthesis and evaluation of ( E)-α-benzylthio chalcones as novel inhibitors of BCR-ABL kinase

by Reddy, M.V. Ramana, Pallela, Venkat R., Cosenza, Stephen C., Mallireddigari, Muralidhar R., Patti, Revathi, Bonagura, Marie, Truongcao, May, Akula, Balaiah, Jatiani, Shashidhar S., Reddy, E. Premkumar
Published in Bioorganic & medicinal chemistry (15.03.2010)

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Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS

Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS

by Cho, Sool Yeon, Cosenza, Stephen C., Pallela, Venkat, Panda, Gayatri, Reddy, M.V. Ramana, Reddy, E. Premkumar, Roboz, John
Published in Journal of pharmaceutical and biomedical analysis (05.03.2013)

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Novel coumarin-3-( N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1

Novel coumarin-3-( N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1

by Reddy, Natala Srinivasa, Gumireddy, Kiranmai, Mallireddigari, Muralidhar R., Cosenza, Stephen C., Venkatapuram, Padmavathi, Bell, Stanley C., Reddy, E. Premkumar, Reddy, M.V. Ramana
Published in Bioorganic & medicinal chemistry (02.05.2005)

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