A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
Giordano-Attianese, Greta, Gainza, Pablo, Gray-Gaillard, Elise, Cribioli, Elisabetta, Shui, Sailan, Kim, Seonghoon, Kwak, Mi-Jeong, Vollers, Sabrina, Corria Osorio, Angel De Jesus, Reichenbach, Patrick, Bonet, Jaume, Oh, Byung-Ha, Irving, Melita, Coukos, George, Correia, Bruno E.
Published in Nature biotechnology (01.04.2020)
Published in Nature biotechnology (01.04.2020)
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Generation of a novel synthetic CD8+ T cell state that leads to tumor control in mice
Published in Nature immunology
(01.05.2023)
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Cryoablation Does Not Significantly Contribute to Systemic Effector Immune Responses in a Poorly Immunogenic B16F10 Melanoma Model
Yakkala, Chakradhar, Corria-Osorio, Jesus, Kandalaft, Lana, Denys, Alban, Koppolu, Bhanu, Duran, Rafael
Published in Clinical cancer research (13.09.2024)
Published in Clinical cancer research (13.09.2024)
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
Herrera, Fernanda G, Ronet, Catherine, Ochoa de Olza, Maria, Barras, David, Crespo, Isaac, Andreatta, Massimo, Corria-Osorio, Jesus, Spill, Aodrenn, Benedetti, Fabrizio, Genolet, Raphael, Orcurto, Angela, Imbimbo, Martina, Ghisoni, Eleonora, Navarro Rodrigo, Blanca, Berthold, Dominik R, Sarivalasis, Apostolos, Zaman, Khalil, Duran, Rafael, Dromain, Clarisse, Prior, John, Schaefer, Niklaus, Bourhis, Jean, Dimopoulou, Georgia, Tsourti, Zoi, Messemaker, Marius, Smith, Thomas, Warren, Sarah E, Foukas, Periklis, Rusakiewicz, Sylvie, Pittet, Mikaël J, Zimmermann, Stefan, Sempoux, Christine, Dafni, Urania, Harari, Alexandre, Kandalaft, Lana E, Carmona, Santiago J, Dangaj Laniti, Denarda, Irving, Melita, Coukos, George
Published in Cancer discovery (01.01.2022)
Published in Cancer discovery (01.01.2022)
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Author Correction: A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
Giordano-Attianese, Greta, Gainza, Pablo, Gray-Gaillard, Elise, Cribioli, Elisabetta, Shui, Sailan, Kim, Seonghoon, Kwak, Mi-Jeong, Vollers, Sabrina, Corria Osorio, Angel De Jesus, Reichenbach, Patrick, Bonet, Jaume, Oh, Byung-Ha, Irving, Melita, Coukos, George, Correia, Bruno E.
Published in Nature biotechnology (01.04.2020)
Published in Nature biotechnology (01.04.2020)
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1540 Age-associated NAD decline impairs mitochondrial fitness and function of CAR-T cells
Hope, Helen Carrasco, Sostoa, Jana de, Ginefra, Pierpaolo, Chiang, Yi-Hsuan, Luna, Cristina Jimenez, Osorio, Jesús Corria, Coukos, George, Migliorini, Denis, Vannini, Nicola
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells
Corria-Osorio, Jesus, Carmona, Santiago J., Stefanidis, Evangelos, Andreatta, Massimo, Ortiz-Miranda, Yaquelin, Muller, Tania, Rota, Ioanna A., Crespo, Isaac, Seijo, Bili, Castro, Wilson, Jimenez-Luna, Cristina, Scarpellino, Leonardo, Ronet, Catherine, Spill, Aodrenn, Lanitis, Evripidis, Romero, Pedro, Luther, Sanjiv A., Irving, Melita, Coukos, George
Published in Nature immunology (01.05.2023)
Published in Nature immunology (01.05.2023)
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Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma
Chiffelle, Johanna, Barras, David, Pétremand, Rémy, Orcurto, Angela, Bobisse, Sara, Arnaud, Marion, Auger, Aymeric, Rodrigo, Blanca Navarro, Ghisoni, Eleonora, Sauvage, Christophe, Saugy, Damien, Michel, Alexandra, Murgues, Baptiste, Fahr, Noémie, Imbimbo, Martina, Ochoa de Olza, Maria, Latifyan, Sofiya, Crespo, Isaac, Benedetti, Fabrizio, Genolet, Raphael, Queiroz, Lise, Schmidt, Julien, Homicsko, Krisztian, Zimmermann, Stefan, Michielin, Olivier, Bassani-Sternberg, Michal, Kandalaft, Lana E., Dafni, Urania, Corria-Osorio, Jesus, Trueb, Lionel, Dangaj Laniti, Denarda, Harari, Alexandre, Coukos, George
Published in Immunity (Cambridge, Mass.) (08.10.2024)
Published in Immunity (Cambridge, Mass.) (08.10.2024)
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PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Morotti, Matteo, Grimm, Alizee J., Hope, Helen Carrasco, Arnaud, Marion, Desbuisson, Mathieu, Rayroux, Nicolas, Barras, David, Masid, Maria, Murgues, Baptiste, Chap, Bovannak S., Ongaro, Marco, Rota, Ioanna A., Ronet, Catherine, Minasyan, Aspram, Chiffelle, Johanna, Lacher, Sebastian B., Bobisse, Sara, Murgues, Clément, Ghisoni, Eleonora, Ouchen, Khaoula, Bou Mjahed, Ribal, Benedetti, Fabrizio, Abdellaoui, Naoill, Turrini, Riccardo, Gannon, Philippe O., Zaman, Khalil, Mathevet, Patrice, Lelievre, Loic, Crespo, Isaac, Conrad, Marcus, Verdeil, Gregory, Kandalaft, Lana E., Dagher, Julien, Corria-Osorio, Jesus, Doucey, Marie-Agnes, Ho, Ping-Chih, Harari, Alexandre, Vannini, Nicola, Böttcher, Jan P., Dangaj Laniti, Denarda, Coukos, George
Published in Nature (London) (09.05.2024)
Published in Nature (London) (09.05.2024)
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Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma
Barras, David, Ghisoni, Eleonora, Chiffelle, Johanna, Orcurto, Angela, Dagher, Julien, Fahr, Noémie, Benedetti, Fabrizio, Crespo, Isaac, Grimm, Alizée J, Morotti, Matteo, Zimmermann, Stefan, Duran, Rafael, Imbimbo, Martina, de Olza, Maria Ochoa, Navarro, Blanca, Homicsko, Krisztian, Bobisse, Sara, Labes, Danny, Tsourti, Zoe, Andriakopoulou, Charitini, Herrera, Fernanda, Pétremand, Rémy, Dummer, Reinhard, Berthod, Gregoire, Kraemer, Anne I, Huber, Florian, Thevenet, Jonathan, Bassani-Sternberg, Michal, Schaefer, Niklaus, Prior, John O, Matter, Maurice, Aedo, Veronica, Dromain, Clarisse, Corria-Osorio, Jesus, Tissot, Stéphanie, Kandalaft, Lana E, Gottardo, Raphael, Pittet, Mikaël, Sempoux, Christine, Michielin, Olivier, Dafni, Urania, Trueb, Lionel, Harari, Alexandre, Laniti, Denarda Dangaj, Coukos, George
Published in Science immunology (02.02.2024)
Published in Science immunology (02.02.2024)
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Journal Article
PGE 2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Morotti, Matteo, Grimm, Alizee J, Hope, Helen Carrasco, Arnaud, Marion, Desbuisson, Mathieu, Rayroux, Nicolas, Barras, David, Masid, Maria, Murgues, Baptiste, Chap, Bovannak S, Ongaro, Marco, Rota, Ioanna A, Ronet, Catherine, Minasyan, Aspram, Chiffelle, Johanna, Lacher, Sebastian B, Bobisse, Sara, Murgues, Clément, Ghisoni, Eleonora, Ouchen, Khaoula, Bou Mjahed, Ribal, Benedetti, Fabrizio, Abdellaoui, Naoill, Turrini, Riccardo, Gannon, Philippe O, Zaman, Khalil, Mathevet, Patrice, Lelievre, Loic, Crespo, Isaac, Conrad, Marcus, Verdeil, Gregory, Kandalaft, Lana E, Dagher, Julien, Corria-Osorio, Jesus, Doucey, Marie-Agnes, Ho, Ping-Chih, Harari, Alexandre, Vannini, Nicola, Böttcher, Jan P, Dangaj Laniti, Denarda, Coukos, George
Published in Nature (London) (24.04.2024)
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Published in Nature (London) (24.04.2024)
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Modulation of CD4 T cell function via CD6-targeting
Freitas, Raquel Filipa, Basto, Afonso, Almeida, Silvia C.P., Santos, Rita F., Gonçalves, Carine M., Corria-Osorio, Jesus, Carvalho, Tânia, Carmo, Alexandre M., Oliveira, Vanessa G., Leon, Kalet, Graca, Luis
Published in EBioMedicine (01.09.2019)
Published in EBioMedicine (01.09.2019)
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Modulation of CD4 T cell function via CD6-targetingResearch in context
Raquel Filipa Freitas, Afonso Basto, Silvia C.P. Almeida, Rita F. Santos, Carine M. Gonçalves, Jesus Corria-Osorio, Tânia Carvalho, Alexandre M. Carmo, Vanessa G. Oliveira, Kalet Leon, Luis Graca
Published in EBioMedicine (01.09.2019)
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Published in EBioMedicine (01.09.2019)
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Orthogonal Gene Engineering Enables CD8+ T Cells to Control Tumors through a Novel PD-1+ TOX-indifferent Synthetic Effector State
Corria-Osorio, Jesus, Carmona, Santiago J, Stefanidis, Evangelos, Andreatta, Massimo J, Muller, Tania, Ortiz, Yaquelin, Seijo, Bili, Castro, Wilson, Jimenez-Luna, Cristina, Scarpellino, Leonardo, Ronet, Catherine, Spill, Aodrenn, Lanitis, Evripidis, Luther, Sanjiv A, Romero, Pedro, Irving, Melita, Coukos, George
Published in bioRxiv (19.02.2022)
Published in bioRxiv (19.02.2022)
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Paper
TGF?-DERIVED POLYPEPTIDES AND USES THEREOF
Saumel PEREZ RODRIGUEZ, Amaury PUPO MERI?O, Angel de Jesus CORRIA OSORIO, Tania CARMENATE PORTILLA, Kalet LEON MONZON
Year of Publication 25.12.2019
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Year of Publication 25.12.2019
Patent
COMPOSTO E MÉTODO PARA IMUNOTERAPIA
ANGEL DE JESUS CORRIA OSORIO, GEORGE COUKOS, MELITA IRVING, VINCENT ZOETE
Year of Publication 09.08.2022
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Year of Publication 09.08.2022
Patent
TGF?-DERIVED POLYPEPTIDES AND THEIR USES
PEREZ RODRIGUEZ, Saumel, CORRIA OSORIO, Jesus, CARMENATE PORTILLA, Tania, PUPO MERINO, Amaury, LEON MONZON, Kalet
Year of Publication 05.07.2020
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Year of Publication 05.07.2020
Patent