Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist
Goncalves, Maria B., Clarke, Earl, Hobbs, Carl, Malmqvist, Tony, Deacon, Robert, Jack, Julian, Corcoran, Jonathan P. T.
Published in The European journal of neuroscience (01.04.2013)
Published in The European journal of neuroscience (01.04.2013)
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Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration
Goncalves, Maria B, Malmqvist, Tony, Clarke, Earl, Hubens, Chantal J, Grist, John, Hobbs, Carl, Trigo, Diogo, Risling, Mårten, Angeria, Maria, Damberg, Peter, Carlstedt, Thomas P, Corcoran, Jonathan P T
Published in The Journal of neuroscience (25.11.2015)
Published in The Journal of neuroscience (25.11.2015)
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C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair
Goncalves, Maria B, Wu, Yue, Clarke, Earl, Grist, John, Moehlin, Julien, Mendoza-Parra, Marco Antonio, Hobbs, Carl, Kalindjian, Barret, Fok, Henry, Mander, Adrian P, Hassanin, Hana, Bendel, Daryl, Täubel, Jörg, Mant, Tim, Carlstedt, Thomas, Jack, Julian, Corcoran, Jonathan P T
Published in Frontiers in molecular neuroscience (20.08.2024)
Published in Frontiers in molecular neuroscience (20.08.2024)
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A retinoic acid receptor β agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord
Agudo, Marta, Yip, Ping, Davies, Meirion, Bradbury, Elizabeth, Doherty, Patrick, McMahon, Stephen, Maden, Malcolm, Corcoran, Jonathan P.T
Published in Neurobiology of disease (01.01.2010)
Published in Neurobiology of disease (01.01.2010)
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The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling
Trigo, Diogo, Goncalves, Maria B., Corcoran, Jonathan P. T.
Published in The FASEB journal (01.06.2019)
Published in The FASEB journal (01.06.2019)
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Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants
Goncalves, Maria B., Mant, Tim, Täubel, Jörg, Clarke, Earl, Hassanin, Hana, Bendel, Daryl, Fok, Henry, Posner, John, Holmes, Jane, Mander, Adrian P., Corcoran, Jonathan P. T.
Published in British journal of clinical pharmacology (01.12.2023)
Published in British journal of clinical pharmacology (01.12.2023)
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Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth
So, Po-Lin, Yip, Ping K., Bunting, Stephen, Wong, Liang-Fong, Mazarakis, Nicholas D., Hall, Susan, McMahon, Stephen, Maden, Malcolm, Corcoran, Jonathan P.T.
Published in Developmental biology (01.10.2006)
Published in Developmental biology (01.10.2006)
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Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth
Goncalves, Maria B., Wu, Yue, Trigo, Diogo, Clarke, Earl, Malmqvist, Tony, Grist, John, Hobbs, Carl, Carlstedt, Thomas P., Corcoran, Jonathan P.T.
Published in Neurobiology of disease (01.03.2018)
Published in Neurobiology of disease (01.03.2018)
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Journal Article
Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury
Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher I., Barret Kalindjian, S., Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
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Journal Article
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist
Clarke, Earl, Jarvis, Christopher I., Goncalves, Maria B., Kalindjian, S. Barret, Adams, David R., Brown, Jane T., Shiers, Jason J., Taddei, David M.A., Ravier, Elodie, Barlow, Stephanie, Miller, Iain, Smith, Vanessa, Borthwick, Alan D., Corcoran, Jonathan P.T.
Published in Bioorganic & medicinal chemistry (15.02.2018)
Published in Bioorganic & medicinal chemistry (15.02.2018)
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Journal Article
RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms
Goncalves, Maria B., Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M., Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P.T.
Published in iScience (25.10.2019)
Published in iScience (25.10.2019)
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Journal Article
RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms
Goncalves, Maria B., Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M., Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P.T.
Published in iScience (22.11.2019)
Published in iScience (22.11.2019)
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Sequential RARβ and α signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways
Goncalves, Maria Beatriz C.V., Agudo, Marta, Connor, Siobhán, McMahon, Stephen, Minger, Stephen L, Maden, Malcolm, Corcoran, Jonathan P.T.
Published in Developmental biology (15.02.2009)
Published in Developmental biology (15.02.2009)
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Corrigendum to “Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury” [Bioorg. Med. Chem. Lett. 29(8) (2019) 995–1000]
Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher I., Kalindjian, S. Barret, Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Amyloid β inhibits retinoic acid synthesis exacerbating A lzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist
Goncalves, Maria B., Clarke, Earl, Hobbs, Carl, Malmqvist, Tony, Deacon, Robert, Jack, Julian, Corcoran, Jonathan P. T.
Published in The European journal of neuroscience (01.04.2013)
Published in The European journal of neuroscience (01.04.2013)
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Journal Article
Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells
Goncalves, Maria Beatriz C.V., Boyle, Julia, Webber, Daniel J., Hall, Sara, Minger, Stephen L., Corcoran, Jonathan P.T.
Published in Developmental biology (01.02.2005)
Published in Developmental biology (01.02.2005)
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Journal Article
Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways
Goncalves, Maria Beatriz C V, Agudo, Marta, Connor, Siobhán, McMahon, Stephen, Minger, Stephen L, Maden, Malcolm, Corcoran, Jonathan P T
Published in Developmental biology (15.02.2009)
Published in Developmental biology (15.02.2009)
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