The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
Seal, Jonathan T, Atkinson, Stephen J, Aylott, Helen, Bamborough, Paul, Chung, Chun-wa, Copley, Royston C. B, Gordon, Laurie, Grandi, Paola, Gray, James R. J, Harrison, Lee A, Hayhow, Thomas G, Lindon, Matthew, Messenger, Cassie, Michon, Anne-Marie, Mitchell, Darren, Preston, Alex, Prinjha, Rab K, Rioja, Inmaculada, Taylor, Simon, Wall, Ian D, Watson, Robert J, Woolven, James M, Demont, Emmanuel H
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Thermal and photochemical annulation of vinyl azides to 2-aminoimidazoles
Man, Lucas, Copley, Royston C. B, Handlon, Anthony L
Published in Organic & biomolecular chemistry (21.07.2019)
Published in Organic & biomolecular chemistry (21.07.2019)
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Journal Article
Asymmetric Synthesis of an N-Acylpyrrolidine for Inhibition of HCV Polymerase
Agbodjan, Armel A., Cooley, Bob E., Copley, Royston C. B., Corfield, John A., Flanagan, Roy C., Glover, Bobby N., Guidetti, Rossella, Haigh, David, Howes, Peter D., Jackson, Mary M., Matsuoka, Richard T., Medhurst, Katrina J., Millar, Alan, Sharp, Matthew J., Slater, Martin J., Toczko, Jennifer F., Xie, Shiping
Published in Journal of organic chemistry (18.04.2008)
Published in Journal of organic chemistry (18.04.2008)
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Journal Article
First global analysis of the GSK database of small molecule crystal structures
Kalash, Leen N, Cole, Jason C, Copley, Royston C. B, Edge, Colin M, Moldovan, Alexandru A, Sadiq, Ghazala, Doherty, Cheryl L
Published in CrystEngComm (28.08.2021)
Published in CrystEngComm (28.08.2021)
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Journal Article
Discovery of Novel 1‑Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists
Lu, Hongfu, Yang, Ting, Xu, Zhongmiao, Lin, Xichen, Ding, Qian, Zhang, Yueting, Cai, Xin, Dong, Kelly, Gong, Sophie, Zhang, Wei, Patel, Metul, Copley, Royston C. B, Xiang, Jianing, Guan, Xiaoming, Wren, Paul, Ren, Feng
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Journal Article
Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis
Anderson, Niall A, Campos, Sebastien, Butler, Sharon, Copley, Royston C. B, Duncan, Ian, Harrison, Stephen, Le, Joelle, Maghames, Rosemary, Pastor-Garcia, Aleix, Pritchard, John M, Rowedder, James E, Smith, Claire E, Thomas, Jack, Vitulli, Giovanni, Macdonald, Simon J. F
Published in Journal of medicinal chemistry (10.10.2019)
Published in Journal of medicinal chemistry (10.10.2019)
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Journal Article
From formulation to structure: 3D electron diffraction for the structure solution of a new indomethacin polymorph from an amorphous solid dispersion
Leung, Helen W., Copley, Royston C. B., Lampronti, Giulio I., Day, Sarah J., Saunders, Lucy K., Johnstone, Duncan N., Midgley, Paul A.
Published in IUCrJ (01.09.2024)
Published in IUCrJ (01.09.2024)
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Journal Article
Conversion of a Benzofuran Ester to an Amide through an Enamine Lactone Pathway: Synthesis of HCV Polymerase Inhibitor GSK852A
Bowman, Roy K, Bullock, Kae M, Copley, Royston C. B, Deschamps, Nicole M, McClure, Michael S, Powers, Jeremiah D, Wolters, Andy M, Wu, Lianming, Xie, Shiping
Published in Journal of organic chemistry (02.10.2015)
Published in Journal of organic chemistry (02.10.2015)
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Journal Article
Synthesis and Structure–Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists
Procopiou, Panayiotis A, Barrett, John W, Barton, Nicholas P, Begg, Malcolm, Clapham, David, Copley, Royston C. B, Ford, Alison J, Graves, Rebecca H, Hall, David A, Hancock, Ashley P, Hill, Alan P, Hobbs, Heather, Hodgson, Simon T, Jumeaux, Coline, Lacroix, Yannick M. L, Miah, Afjal H, Morriss, Karen M. L, Needham, Deborah, Sheriff, Emma B, Slack, Robert J, Smith, Claire E, Sollis, Steven L, Staton, Hugo
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Journal Article
Elucidating the Pathways of Degradation of Denagliptin
Joshi, Biren K., Ramsey, Beverly, Johnson, Byron, Patterson, Daniel E., Powers, Jeremiah, Facchine, Kevin L., Osterhout, Martin, Leblanc, Michael P., Bryant-Mills, Renetta, Copley, Royston C.B., Sides, Scott L.
Published in Journal of pharmaceutical sciences (01.07.2010)
Published in Journal of pharmaceutical sciences (01.07.2010)
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Journal Article
Solid-State NMR Analysis of a Boron-Containing Pharmaceutical Hydrochloride Salt
Vogt, Frederick G., Williams, Glenn R., Copley, Royston C.B.
Published in Journal of pharmaceutical sciences (01.10.2013)
Published in Journal of pharmaceutical sciences (01.10.2013)
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Journal Article
Evaluating a Crystal Energy Landscape in the Context of Industrial Polymorph Screening
Ismail, Salima Z, Anderton, Clare L, Copley, Royston C. B, Price, Louise S, Price, Sarah L
Published in Crystal growth & design (05.06.2013)
Published in Crystal growth & design (05.06.2013)
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Journal Article
Multidimensional Electron Diffraction-Microscopy of Cabotegravir Nanocrystals
Johnstone, Duncan N., Copley, Royston C. B., Graves, Rachel G., Brum, Jeffrey, Midgley, Paul A.
Published in Microscopy and microanalysis (01.08.2019)
Published in Microscopy and microanalysis (01.08.2019)
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Journal Article
A Spectroscopic and Diffractometric Study of Polymorphism in Ethyl 3‑{3-[((2R)‑3-{[2-(2,3-dihydro‑1H‑inden-2-yl)-1,1-dimethylethyl]amino}-2-hydroxypropyl)oxy]-4,5-difluorophenyl}propanoate Hydrochloride
Vogt, Frederick G, Williams, Glenn R, Johnson, Matthew N, Copley, Royston C. B
Published in Crystal growth & design (04.12.2013)
Published in Crystal growth & design (04.12.2013)
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Journal Article
Effect of Particle Size and Morphology on the Dehydration Mechanism of a Non-Stoichiometric Hydrate
Kang, Feirong, Vogt, Frederick G, Brum, Jeffrey, Forcino, Rachel, Copley, Royston C. B, Williams, Glenn, Carlton, Robert
Published in Crystal growth & design (01.01.2012)
Published in Crystal growth & design (01.01.2012)
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Journal Article
Studying the Origin of the Antiferromagnetic to Spin-Canting Transition in the β-p-NCC6F4CNSSN. Molecular Magnet
Deumal, Mercè, Rawson, Jeremy M., Goeta, Andrés E., Howard, Judith A. K., Copley, Royston C. B., Robb, Michael A., Novoa, Juan J.
Published in Chemistry : a European journal (01.03.2010)
Published in Chemistry : a European journal (01.03.2010)
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Journal Article
Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists
Miah, Afjal H., Copley, Royston C. B., O'Flynn, Daniel, Percy, Jonathan M., Procopiou, Panayiotis A.
Published in Organic & biomolecular chemistry (21.03.2014)
Published in Organic & biomolecular chemistry (21.03.2014)
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Journal Article
Isomorphism, Disorder, and Hydration in the Crystal Structures of Racemic and Single-Enantiomer Carvedilol Phosphate
Vogt, Frederick G, Copley, Royston C. B, Mueller, Ronald L, Spoors, Grant P, Cacchio, Thomas N, Carlton, Robert A, Katrincic, Lee M, Kennady, James M, Parsons, Simon, Chetina, Olga V
Published in Crystal growth & design (02.06.2010)
Published in Crystal growth & design (02.06.2010)
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Journal Article