Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo
M. Bader, Stefanie, Cooney, James P., Bhandari, Reet, Mackiewicz, Liana, Dayton, Merle, Sheerin, Dylan, Georgy, Smitha Rose, Murphy, James M., Davidson, Kathryn C., Allison, Cody C., Pellegrini, Marc, Doerflinger, Marcel
Published in Cell death & disease (30.01.2024)
Published in Cell death & disease (30.01.2024)
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Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
Wines, Bruce D, Kurtovic, Liriye, Trist, Halina M, Esparon, Sandra, Lopez, Ester, Chappin, Klasina, Chan, Li-Jin, Mordant, Francesca L, Lee, Wen Shi, Gherardin, Nicholas A, Patel, Sheila K, Hartley, Gemma E, Pymm, Phillip, Cooney, James P, Beeson, James G, Godfrey, Dale I, Burrell, Louise M, van Zelm, Menno C, Wheatley, Adam K, Chung, Amy W, Tham, Wai-Hong, Subbarao, Kanta, Kent, Stephen J, Hogarth, P Mark
Published in Frontiers in immunology (28.07.2022)
Published in Frontiers in immunology (28.07.2022)
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Journal Article
Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
Wines, Bruce D, Kurtovic, Liriye, Trist, Halina M, Esparon, Sandra, Lopez, Ester, Chappin, Klasina, Chan, Li-Jin, Mordant, Francesca L, Lee, Wen Shi, Gherardin, Nicholas A, Patel, Sheila K, Hartley, Gemma E, Pymm, Phillip, Cooney, James P, Beeson, James G, Godfrey, Dale I, Burrell, Louise M, van Zelm, Menno C, Wheatley, Adam K, Chung, Amy W, Tham, Wai-Hong, Subbarao, Kanta, Kent, Stephen J, Hogarth, P Mark
Published in Frontiers in immunology (10.01.2023)
Published in Frontiers in immunology (10.01.2023)
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Journal Article
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
Calleja, Dale J, Kuchel, Nathan, Lu, Bernadine G C, Birkinshaw, Richard W, Klemm, Theresa, Doerflinger, Marcel, Cooney, James P, Mackiewicz, Liana, Au, Amanda E, Yap, Yu Q, Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E, Call, Melissa J, Lechtenberg, Bernhard C, Czabotar, Peter E, Pellegrini, Marc, Charman, Susan A, Lowes, Kym N, Mitchell, Jeffrey P, Nachbur, Ueli, Lessene, Guillaume, Komander, David
Published in Frontiers in chemistry (12.04.2022)
Published in Frontiers in chemistry (12.04.2022)
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Journal Article
Programmed cell death: the pathways to severe COVID-19?
Bader, Stefanie M, Cooney, James P, Pellegrini, Marc, Doerflinger, Marcel
Published in Biochemical journal (18.03.2022)
Published in Biochemical journal (18.03.2022)
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Journal Article
Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2
Pymm, Phillip, Redmond, Samuel J., Dolezal, Olan, Mordant, Francesca, Lopez, Ester, Cooney, James P., Davidson, Kathryn C., Haycroft, Ebene R., Tan, Chee Wah, Seneviratna, Rebecca, Grimley, Samantha L., Purcell, Damian F.J., Kent, Stephen J., Wheatley, Adam K., Wang, Lin-Fa, Leis, Andrew, Glukhova, Alisa, Pellegrini, Marc, Chung, Amy W., Subbarao, Kanta, Uldrich, Adam P., Tham, Wai-Hong, Godfrey, Dale I., Gherardin, Nicholas A.
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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Journal Article
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Published in The EMBO journal (15.09.2020)
Published in The EMBO journal (15.09.2020)
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Journal Article
Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
Pymm, Phillip, Adair, Amy, Chan, Li-Jin, Cooney, James P., Mordant, Francesca L., Allison, Cody C., Lopez, Ester, Haycroft, Ebene R., O’Neill, Matthew T., Tan, Li Lynn, Dietrich, Melanie H., Drew, Damien, Doerflinger, Marcel, Dengler, Michael A., Scott, Nichollas E., Wheatley, Adam K., Gherardin, Nicholas A., Venugopal, Hariprasad, Cromer, Deborah, Davenport, Miles P., Pickering, Raelene, Godfrey, Dale I., Purcell, Damian F. J., Kent, Stephen J., Chung, Amy W., Subbarao, Kanta, Pellegrini, Marc, Glukhova, Alisa, Tham, Wai-Hong
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.2021)
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Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.
Published in Immunity (Cambridge, Mass.) (08.03.2022)
Published in Immunity (Cambridge, Mass.) (08.03.2022)
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Journal Article
Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies
Preston, Simon P., Stutz, Michael D., Allison, Cody C., Nachbur, Ueli, Gouil, Quentin, Tran, Bang Manh, Duvivier, Valerie, Arandjelovic, Philip, Cooney, James P., Mackiewicz, Liana, Meng, Yanxiang, Schaefer, Jan, Bader, Stefanie M., Peng, Hongke, Valaydon, Zina, Rajasekaran, Pravin, Jennison, Charlie, Lopaticki, Sash, Farrell, Ann, Ryan, Marno, Howell, Jess, Croagh, Catherine, Karunakaran, Denuja, Schuster-Klein, Carole, Murphy, James M., Fifis, Theodora, Christophi, Christopher, Vincan, Elizabeth, Blewitt, Marnie E., Thompson, Alexander, Boddey, Justin A., Doerflinger, Marcel, Pellegrini, Marc
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2022)
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SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates
Bader, Stefanie M, Cooney, James P, Sheerin, Dylan, Taiaroa, George, Harty, Leigh, Davidson, Kathryn C, Mackiewicz, Liana, Dayton, Merle, Wilcox, Stephen, Whitehead, Lachlan, Rogers, Kelly L, Georgy, Smitha Rose, Coussens, Anna K, Grimley, Samantha L, Corbin, Vincent, Pitt, Miranda, Coin, Lachlan, Pickering, Raelene, Thomas, Merlin, Allison, Cody C, McAuley, Julie, Purcell, Damian F J, Doerflinger, Marcel, Pellegrini, Marc
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2023)
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Journal Article
Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain
Wheatley, Adam K., Pymm, Phillip, Esterbauer, Robyn, Dietrich, Melanie H., Lee, Wen Shi, Drew, Damien, Kelly, Hannah G., Chan, Li-Jin, Mordant, Francesca L., Black, Katrina A., Adair, Amy, Tan, Hyon-Xhi, Juno, Jennifer A., Wragg, Kathleen M., Amarasena, Thakshila, Lopez, Ester, Selva, Kevin J., Haycroft, Ebene R., Cooney, James P., Venugopal, Hariprasad, Tan, Li Lynn, O Neill, Matthew T., Allison, Cody C., Cromer, Deborah, Davenport, Miles P., Bowen, Richard A., Chung, Amy W., Pellegrini, Marc, Liddament, Mark T., Glukhova, Alisa, Subbarao, Kanta, Kent, Stephen J., Tham, Wai-Hong
Published in Cell reports (Cambridge) (12.10.2021)
Published in Cell reports (Cambridge) (12.10.2021)
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Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice
Arandjelovic, Philip, Kim, Youry, Cooney, James P, Preston, Simon P, Doerflinger, Marcel, McMahon, James H, Garner, Sarah E, Zerbato, Jennifer M, Roche, Michael, Tumpach, Carolin, Ong, Jesslyn, Sheerin, Dylan, Smyth, Gordon K, Anderson, Jenny L, Allison, Cody C, Lewin, Sharon R, Pellegrini, Marc
Published in Cell reports. Medicine (19.09.2023)
Published in Cell reports. Medicine (19.09.2023)
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Journal Article
Rapid detection of monkeypox virus using a CRISPR-Cas12a mediated assay: a laboratory validation and evaluation study
Low, Soo Jen, O'Neill, Matthew T, Kerry, William J, Krysiak, Marcelina, Papadakis, Georgina, Whitehead, Lachlan W, Savic, Ivana, Prestedge, Jacqueline, Williams, Lewis, Cooney, James P, Tran, Thomas, Lim, Chuan K, Caly, Leon, Towns, Janet M, Bradshaw, Catriona S, Fairley, Christopher, Chow, Eric P F, Chen, Marcus Y, Pellegrini, Marc, Pasricha, Shivani, Williamson, Deborah A
Published in The Lancet. Microbe (01.10.2023)
Published in The Lancet. Microbe (01.10.2023)
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Journal Article
Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine
Deliyannis, Georgia, Gherardin, Nicholas A., Wong, Chinn Yi, Grimley, Samantha L., Cooney, James P., Redmond, Samuel J., Ellenberg, Paula, Davidson, Kathryn C., Mordant, Francesca L., Smith, Tim, Gillard, Marianne, Lopez, Ester, McAuley, Julie, Tan, Chee Wah, Wang, Jing J., Zeng, Weiguang, Littlejohn, Mason, Zhou, Runhong, Fuk-Woo Chan, Jasper, Chen, Zhi-wei, Hartwig, Airn E., Bowen, Richard, Mackenzie, Jason M., Vincan, Elizabeth, Torresi, Joseph, Kedzierska, Katherine, Pouton, Colin W., Gordon, Tom P., Wang, Lin-fa, Kent, Stephen J., Wheatley, Adam K., Lewin, Sharon R., Subbarao, Kanta, Chung, Amy W., Pellegrini, Marc, Munro, Trent, Nolan, Terry, Rockman, Steven, Jackson, David C., Purcell, Damian F.J., Godfrey, Dale I.
Published in EBioMedicine (01.06.2023)
Published in EBioMedicine (01.06.2023)
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Human Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle Vaccine
Carrera Montoya, Julio, Collett, Simon, Fernandez Ruiz, Daniel, Earnest, Linda, Edeling, Melissa A., Yap, Ashley Huey Yiing, Wong, Chinn Yi, Cooney, James P., Davidson, Kathryn C., Roberts, Jason, Rockman, Steven, Tran, Bang M., McAuley, Julie L., Deliyannis, Georgia, Grimley, Samantha L., Purcell, Damian F. J., Waters, Shafagh A., Godfrey, Dale I., Hans, Dhiraj, Pellegrini, Marc, Mackenzie, Jason M., Vincan, Elizabeth, Heath, William R., Torresi, Joseph
Published in Organoids (01.02.2024)
Published in Organoids (01.02.2024)
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ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system
Lin, Amy E, Ebert, Gregor, Ow, Yongkai, Preston, Simon P, Toe, Jesse G, Cooney, James P, Scott, Hamish W, Sasaki, Masato, Saibil, Samuel D, Dissanayake, Dilan, Kim, Raymond H, Wakeham, Andrew, You-Ten, Annick, Shahinian, Arda, Duncan, Gordon, Silvester, Jennifer, Ohashi, Pamela S, Mak, Tak W, Pellegrini, Marc
Published in Nature immunology (01.01.2013)
Published in Nature immunology (01.01.2013)
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Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccineResearch in context
Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F.J. Purcell, Dale I. Godfrey
Published in EBioMedicine (01.06.2023)
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Published in EBioMedicine (01.06.2023)
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