Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia
Turner, Joseph D, Pionnier, Nicolas, Furlong-Silva, Julio, Sjoberg, Hanna, Cross, Stephen, Halliday, Alice, Guimaraes, Ana F, Cook, Darren A N, Steven, Andrew, Van Rooijen, Nico, Allen, Judith E, Jenkins, Stephen J, Taylor, Mark J
Published in PLoS pathogens (01.03.2018)
Published in PLoS pathogens (01.03.2018)
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Preclinical development of an oral anti- Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis
Taylor, Mark J, von Geldern, Thomas W, Ford, Louise, Hübner, Marc P, Marsh, Kennan, Johnston, Kelly L, Sjoberg, Hanna T, Specht, Sabine, Pionnier, Nicolas, Tyrer, Hayley E, Clare, Rachel H, Cook, Darren A N, Murphy, Emma, Steven, Andrew, Archer, John, Bloemker, Dominique, Lenz, Franziska, Koschel, Marianne, Ehrens, Alexandra, Metuge, Haelly M, Chunda, Valerinne C, Ndongmo Chounna, Patrick W, Njouendou, Abdel J, Fombad, Fanny F, Carr, Robert, Morton, Howard E, Aljayyoussi, Ghaith, Hoerauf, Achim, Wanji, Samuel, Kempf, Dale J, Turner, Joseph D, Ward, Stephen A
Published in Science translational medicine (13.03.2019)
Published in Science translational medicine (13.03.2019)
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Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
Casewell, Nicholas R., Wagstaff, Simon C., Wüster, Wolfgang, Cook, Darren A. N., Bolton, Fiona M. S., King, Sarah I., Pla, Davinia, Sanz, Libia, Calvete, Juan J., Harrison, Robert A.
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2014)
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Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis
Jacobs, Robert T, Lunde, Christopher S, Freund, Yvonne R, Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S, Berry, Pamela W, Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J, Ford, Louise, Johnston, Kelly L, Cook, Darren A. N, Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F, Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J, Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P, McNamara, Case W, Bakowski, Malina A, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Clare, Rachel H, Bardelle, Catherine, Harper, Paul, Hong, W David, Börjesson, Ulf, Johnston, Kelly L, Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A N, Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L, Slatko, Barton E, Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G, O'Neill, Paul M, Taylor, Mark J, Ward, Stephen A
Published in Nature communications (02.01.2019)
Published in Nature communications (02.01.2019)
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Research strategies to improve snakebite treatment: Challenges and progress
Harrison, Robert A., Cook, Darren A., Renjifo, Camila, Casewell, Nicholas R., Currier, Rachel B., Wagstaff, Simon C.
Published in Journal of proteomics (24.08.2011)
Published in Journal of proteomics (24.08.2011)
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Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom
Casewell, Nicholas R, Cook, Darren A N, Wagstaff, Simon C, Nasidi, Abdulsalami, Durfa, Nandul, Wüster, Wolfgang, Harrison, Robert A
Published in PLoS neglected tropical diseases (26.10.2010)
Published in PLoS neglected tropical diseases (26.10.2010)
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Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
Aljayyoussi, Ghaith, Tyrer, Hayley E, Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A N, Steven, Andrew, Sharma, Raman, Guimaraes, Ana F, Clare, Rachel H, Cassidy, Andrew, Johnston, Kelly L, Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A
Published in Scientific reports (16.03.2017)
Published in Scientific reports (16.03.2017)
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Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner
Schroeder, Jan-Hendrik, McCarthy, David, Szestak, Tadge, Cook, Darren A, Taylor, Mark J, Craig, Alister G, Lawson, Charlotte, Lawrence, Rachel A
Published in PLoS neglected tropical diseases (08.05.2017)
Published in PLoS neglected tropical diseases (08.05.2017)
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Analysis of camelid IgG for antivenom development: Serological responses of venom-immunised camels to prepare either monospecific or polyspecific antivenoms for West Africa
Cook, Darren A.N., Owen, Timothy, Wagstaff, Simon C., Kinne, Joerg, Wernery, Ulrich, Harrison, Robert A.
Published in Toxicon (Oxford) (01.09.2010)
Published in Toxicon (Oxford) (01.09.2010)
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Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis
Clare, Rachel H, Cook, Darren A N, Johnston, Kelly L, Ford, Louise, Ward, Stephen A, Taylor, Mark J
Published in Journal of biomolecular screening (01.01.2015)
Published in Journal of biomolecular screening (01.01.2015)
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Analysis of camelid IgG for antivenom development: Immunoreactivity and preclinical neutralisation of venom-induced pathology by IgG subclasses, and the effect of heat treatment
Cook, Darren A.N., Samarasekara, Chamali L., Wagstaff, Simon C., Kinne, Joerg, Wernery, Ulrich, Harrison, Robert A.
Published in Toxicon (Oxford) (15.09.2010)
Published in Toxicon (Oxford) (15.09.2010)
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Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
Aljayyoussi, Ghaith, Tyrer, Hayley E, Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A N, Steven, Andrew, Sharma, Raman, Guimaraes, Ana F, Clare, Rachel H, Cassidy, Andrew, Johnston, Kelly L, Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A
Published in Scientific reports (18.01.2018)
Published in Scientific reports (18.01.2018)
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Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment
Quek, Shannon, Cook, Darren A N, Wu, Yang, Marriott, Amy E, Steven, Andrew, Johnston, Kelly L, Ford, Louise, Archer, John, Hemingway, Janet, Ward, Stephen A, Wagstaff, Simon C, Turner, Joseph D, Taylor, Mark J
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2022)
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AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2019)
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Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis
Turner, Joseph D., Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Priestley, Richard S., Murphy, Emma A., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., McCall, John, Ford, Louise, Hemingway, Janet, Ward, Stephen A., Taylor, Mark J.
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
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Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis
Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E, Gamble, Joanne, Hayward, Laura, Guimaraes, Ana F, Davies, Jill, Waterhouse, David, Cook, Darren A N, Myhill, Laura J, Clare, Rachel H, Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L, Ford, Louise, Turner, Joseph D, Ward, Stephen A, Taylor, Mark J
Published in Scientific reports (21.03.2016)
Published in Scientific reports (21.03.2016)
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Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis
McGillan, Paul, Berry, Neil G, Nixon, Gemma L, Leung, Suet C, Webborn, Peter J. H, Wenlock, Mark C, Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H, Cook, Darren A, Johnston, Kelly L, Ford, Louise, Ward, Stephen A, Taylor, Mark J, Hong, W. David, O’Neill, Paul M
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
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