Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery
Chaturvedula, Prasad V., Mercer, Stephen E., Pin, Sokhom S., Thalody, George, Xu, Cen, Conway, Charlie M., Keavy, Deborah, Signor, Laura, Cantor, Glenn H., Mathias, Neil, Moench, Paul, Denton, Rex, Macci, Robert, Schartman, Richard, Whiterock, Valerie, Davis, Carl, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor
Chaturvedula, Prasad V., Pin, Sokhom, Tholady, George, Conway, Charlie M., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Serendipitous oxidation product of BIBN4096BS: A potent CGRP receptor antagonist
Dasgupta, Bireshwar, Kozlowski, Edward, Schroeder, Daniel R., Torrente, John R., Xu, Cen, Pin, Sokhom, Conway, Charlie M., Dubowchik, Gene M., Macor, John E., Vrudhula, Vivekananda M.
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
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