IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Gaggero, Silvia, Martinez-Fabregas, Jonathan, Cozzani, Adeline, Fyfe, Paul K, Leprohon, Malo, Yang, Jie, Thomasen, F Emil, Winkelmann, Hauke, Magnez, Romain, Conti, Alberto G, Wilmes, Stephan, Pohler, Elizabeth, van Gijsel Bonnello, Manuel, Thuru, Xavier, Quesnel, Bruno, Soncin, Fabrice, Piehler, Jacob, Lindorff-Larsen, Kresten, Roychoudhuri, Rahul, Moraga, Ignacio, Mitra, Suman
Published in Science immunology (16.12.2022)
Published in Science immunology (16.12.2022)
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CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function
Whiteside, Sarah K., Grant, Francis M., Gyori, David S., Conti, Alberto G., Imianowski, Charlotte J., Kuo, Paula, Nasrallah, Rabab, Sadiyah, Firas, Lira, Sergio A., Tacke, Frank, Eil, Robert L., Burton, Oliver T., Dooley, James, Liston, Adrian, Okkenhaug, Klaus, Yang, Jie, Roychoudhuri, Rahul
Published in Immunology (01.08.2021)
Published in Immunology (01.08.2021)
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IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy
Imianowski, Charlotte J., Kuo, Paula, Whiteside, Sarah K., von Linde, Teresa, Wesolowski, Alexander J., Conti, Alberto G., Evans, Alexander C., Baird, Tarrion, Morris, Benjamin I., Fletcher, Nicole E., Yang, Jie, Poon, Edmund, Lakins, Matthew A., Yamamoto, Masahiro, Brewis, Neil, Morrow, Michelle, Roychoudhuri, Rahul
Published in Cancer research communications (01.08.2024)
Published in Cancer research communications (01.08.2024)
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Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion
Whiteside, Sarah K, Grant, Francis M, Alvisi, Giorgia, Clarke, James, Tang, Leqi, Imianowski, Charlotte J, Zhang, Baojie, Evans, Alexander C, Wesolowski, Alexander J, Conti, Alberto G, Yang, Jie, Lauder, Sarah N, Clement, Mathew, Humphreys, Ian R, Dooley, James, Burton, Oliver, Liston, Adrian, Alloisio, Marco, Voulaz, Emanuele, Langhorne, Jean, Okkenhaug, Klaus, Lugli, Enrico, Roychoudhuri, Rahul
Published in Science immunology (22.12.2023)
Published in Science immunology (22.12.2023)
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The Toll-like receptor 4 pathway modulates response to anti-PD-1 therapy
Whiteside, Sarah K., Beresford-Jones, Benjamin S., Sadar, Puspendu, Kuo, Paula, Xia, Wangmingyu, Suyama, Satoshi, Evans, Alexander C., Imianowski, Charlotte J., Conti, Alberto G., Wesolowski, Alexander J., Soderholm, Amelia, Tourlomousis, Panagiotis, Okkenhaug, Klaus, Bryant, Clare E., Pedicord, Virginia, Roychoudhuri, Rahul
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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