Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A
Morais, Thiago R, Conserva, Geanne A Alves, Varela, Marina T, Costa-Silva, Thais A, Thevenard, Fernanda, Ponci, Vitor, Fortuna, Ana, Falcão, Amílcar C, Tempone, Andre G, Fernandes, João Paulo S, Lago, João Henrique G
Published in Scientific reports (25.03.2020)
Published in Scientific reports (25.03.2020)
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Journal Article
Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)
Costa-Silva, Thais A. da, Conserva, Geanne A. Alves, Galisteo Jr, Andrés J., Tempone, Andre G., Lago, João Henrique G.
Published in The journal of venomous animals and toxins including tropical diseases (2019)
Published in The journal of venomous animals and toxins including tropical diseases (2019)
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Unsaturated lipids modulating the interaction of the antileishmanial isolinderanolide E with models of cellular membranes
Rosa, Matheus Elias, Alves Conserva, Geanne A., Passero, Luiz Felipe D., Lago, João Henrique G., Caseli, Luciano
Published in Bioorganic chemistry (01.07.2022)
Published in Bioorganic chemistry (01.07.2022)
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Journal Article
Butenolides from Nectandra oppositifolia (Lauraceae) displayed anti-Trypanosoma cruzi activity via deregulation of mitochondria
Conserva, Geanne A. Alves, da Costa-Silva, Thais A., Amaral, Maiara, Antar, Guilherme M., Neves, Bruno J., Andrade, Carolina H., Tempone, Andre G., Lago, João Henrique G.
Published in Phytomedicine (Stuttgart) (15.02.2019)
Published in Phytomedicine (Stuttgart) (15.02.2019)
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Journal Article
Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses
Alves Conserva, Geanne A, Quirós-Guerrero, Luis M, Costa-Silva, Thais A, Marcourt, Laurence, Pinto, Erika G, Tempone, Andre G, Fernandes, João Paulo S, Wolfender, Jean-Luc, Queiroz, Emerson F, Lago, João Henrique G
Published in PloS one (25.02.2021)
Published in PloS one (25.02.2021)
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Journal Article
Aporphine Alkaloids from Ocotea puberula with Anti‐Trypanosoma Cruzi Potential – Activity of Dicentrine‐β‐N‐Oxide in the Plasma Membrane Electric Potentials
Barbosa, Henrique, Costa‐Silva, Thais A., Alves Conserva, Geanne A., Araujo, Adelson J., Lordello, Ana Luísa L., Antar, Guilherme M., Amaral, Maiara, Soares, Marisi G., Tempone, Andre G., Lago, João Henrique G.
Published in Chemistry & biodiversity (01.04.2021)
Published in Chemistry & biodiversity (01.04.2021)
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Journal Article
Monolayer nanoarchitectonics at the air-water interface for molecular understanding of the interaction of isolinderanolide E with cholesterol
Rosa, Matheus Elias, Conserva, Geanne A. Alves, Lago, João Henrique G., Caseli, Luciano
Published in Thin solid films (31.07.2022)
Published in Thin solid films (31.07.2022)
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Journal Article
Antitrypanosomal activity and evaluation of the mechanism of action of dehydrodieugenol isolated from Nectandra leucantha (Lauraceae) and its methylated derivative against Trypanosoma cruzi
Grecco, Simone S., Costa-Silva, Thais A., Jerz, Gerold, de Sousa, Fernanda S., Alves Conserva, Geanne A., Mesquita, Juliana T., Galuppo, Mariana K., Tempone, Andre G., Neves, Bruno J., Andrade, Carolina H., Cunha, Rodrigo L.O.R., Uemi, Miriam, Sartorelli, Patricia, Lago, João Henrique G.
Published in Phytomedicine (Stuttgart) (15.01.2017)
Published in Phytomedicine (Stuttgart) (15.01.2017)
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Journal Article
Bioactivity-guided isolation of laevicarpin, an antitrypanosomal and anticryptococcal lactam from Piper laevicarpu (Piperaceae)
da Silva A. Maciel, Dayany, Freitas, Viviane P., Conserva, Geanne A. Alves, Alexandre, Tatiana R., Purisco, Sonia U., Tempone, Andre G., Melhem, Márcia Souza C., Kato, Massuo J., Guimarães, Elsie F., Lago, João Henrique G.
Published in Fitoterapia (01.06.2016)
Published in Fitoterapia (01.06.2016)
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Journal Article
Antileishmanial activity and immunomodulatory effect of seco subamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)
da Costa-Silva, Thais A, Conserva, Geanne A Alves, Galisteo, Jr, Andrés J, Tempone, Andre G, Lago, João Henrique G
Published in The journal of venomous animals and toxins including tropical diseases (2019)
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Published in The journal of venomous animals and toxins including tropical diseases (2019)
Journal Article