Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770
Yeh, Han-I, Qiu, Liming, Sohma, Yoshiro, Conrath, Katja, Zou, Xiaoqin, Hwang, Tzyh-Chang
Published in The Journal of general physiology (01.07.2019)
Published in The Journal of general physiology (01.07.2019)
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Journal Article
General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
Vincke, Cécile, Loris, Remy, Saerens, Dirk, Martinez-Rodriguez, Sergio, Muyldermans, Serge, Conrath, Katja
Published in The Journal of biological chemistry (30.01.2009)
Published in The Journal of biological chemistry (30.01.2009)
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Journal Article
A common mechanism for CFTR potentiators
Yeh, Han-I, Sohma, Yoshiro, Conrath, Katja, Hwang, Tzyh-Chang
Published in The Journal of general physiology (04.12.2017)
Published in The Journal of general physiology (04.12.2017)
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Journal Article
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases
Van Rompaey, Luc, Galien, René, van der Aar, Ellen M, Clement-Lacroix, Philippe, Nelles, Luc, Smets, Bart, Lepescheux, Liên, Christophe, Thierry, Conrath, Katja, Vandeghinste, Nick, Vayssiere, Béatrice, De Vos, Steve, Fletcher, Stephen, Brys, Reginald, van 't Klooster, Gerben, Feyen, Jean H M, Menet, Christel
Published in The Journal of immunology (1950) (01.10.2013)
Published in The Journal of immunology (1950) (01.10.2013)
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Journal Article
Molecular Basis for the Preferential Cleft Recognition by Dromedary Heavy-Chain Antibodies
De Genst, Erwin, Silence, Karen, Decanniere, Klaas, Conrath, Katja, Loris, Remy, Kinne, Jörg, Muyldermans, Serge, Wyns, Lode
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2006)
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Journal Article
Discovery of 9‑Cyclopropylethynyl-2-((S)‑1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1‑a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial
Labéguère, Frédéric, Dupont, Sonia, Alvey, Luke, Soulas, Florilène, Newsome, Gregory, Tirera, Amynata, Quenehen, Vanessa, Mai, Thi Thu Trang, Deprez, Pierre, Blanqué, Roland, Oste, Line, Le Tallec, Sandrine, De Vos, Steve, Hagers, Annick, Vandevelde, Ann, Nelles, Luc, Vandervoort, Nele, Conrath, Katja, Christophe, Thierry, van der Aar, Ellen, Wakselman, Emanuelle, Merciris, Didier, Cottereaux, Céline, da Costa, Cécile, Saniere, Laurent, Clement-Lacroix, Philippe, Jenkins, Laura, Milligan, Graeme, Fletcher, Stephen, Brys, Reginald, Gosmini, Romain
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Journal Article
Discovery of N‑(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro‑4H‑thieno[2,3‑c]pyran-2-yl)‑lH‑pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent
Van der Plas, Steven E, Kelgtermans, Hans, De Munck, Tom, Martina, Sébastien L. X, Dropsit, Sébastien, Quinton, Evelyne, De Blieck, Ann, Joannesse, Caroline, Tomaskovic, Linda, Jans, Mia, Christophe, Thierry, van der Aar, Ellen, Borgonovi, Monica, Nelles, Luc, Gees, Maarten, Stouten, Pieter, Van Der Schueren, Jan, Mammoliti, Oscar, Conrath, Katja, Andrews, Martin
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Journal Article
Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors
Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (14.09.2017)
Published in Journal of medicinal chemistry (14.09.2017)
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Journal Article
A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ
van der Schaar, Hilde M, Leyssen, Pieter, Thibaut, Hendrik J, de Palma, Armando, van der Linden, Lonneke, Lanke, Kjerstin H W, Lacroix, Céline, Verbeken, Erik, Conrath, Katja, Macleod, Angus M, Mitchell, Dale R, Palmer, Nicholas J, van de Poël, Hervé, Andrews, Martin, Neyts, Johan, van Kuppeveld, Frank J M
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
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Journal Article
Biophysical Properties of Camelid VHH Domains Compared to Those of Human VH3 Domains
Ewert, Stefan, Cambillau, Christian, Conrath, Katja, Plückthun, Andreas
Published in Biochemistry (Easton) (19.03.2002)
Published in Biochemistry (Easton) (19.03.2002)
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Journal Article
Antibody repertoire development in camelids
De Genst, Erwin, Saerens, Dirk, Muyldermans, Serge, Conrath, Katja
Published in Developmental and comparative immunology (2006)
Published in Developmental and comparative immunology (2006)
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Journal Article
Identification and Characterization of Novel CFTR Potentiators
Gees, Maarten, Musch, Sara, Van der Plas, Steven, Wesse, Anne-Sophie, Vandevelde, Ann, Verdonck, Katleen, Mammoliti, Oscar, Hwang, Tzyh-Chang, Sonck, Kathleen, Stouten, Pieter, Swensen, Andrew M, Jans, Mia, Van der Schueren, Jan, Nelles, Luc, Andrews, Martin, Conrath, Katja
Published in Frontiers in pharmacology (26.10.2018)
Published in Frontiers in pharmacology (26.10.2018)
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Journal Article
Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies
Saerens, Dirk, Pellis, Mireille, Loris, Remy, Pardon, Els, Dumoulin, Mireille, Matagne, André, Wyns, Lode, Muyldermans, Serge, Conrath, Katja
Published in Journal of molecular biology (23.09.2005)
Published in Journal of molecular biology (23.09.2005)
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A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies
Pellis, Mireille, Pardon, Els, Zolghadr, Kourosh, Rothbauer, Ulrich, Vincke, Cécile, Kinne, Joerg, Dierynck, Inge, Hertogs, Kurt, Leonhardt, Heinrich, Messens, Joris, Muyldermans, Serge, Conrath, Katja
Published in Archives of biochemistry and biophysics (15.10.2012)
Published in Archives of biochemistry and biophysics (15.10.2012)
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Journal Article
Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators
de Wilde, Gert, Gees, Maarten, Musch, Sara, Verdonck, Katleen, Jans, Mia, Wesse, Anne-Sophie, Singh, Ashvani K, Hwang, Tzyh-Chang, Christophe, Thierry, Pizzonero, Mathieu, Van der Plas, Steven, Desroy, Nicolas, Cowart, Marlon, Stouten, Pieter, Nelles, Luc, Conrath, Katja
Published in Frontiers in pharmacology (09.05.2019)
Published in Frontiers in pharmacology (09.05.2019)
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Journal Article
β-Lactamase Inhibitors Derived from Single-Domain Antibody Fragments Elicited in the Camelidae
CONRATH, Katja E, LAUWEREYS, Marc, GALLENI, Moreno, MATAGNE, André, FRERE, Jean-Marie, KINNE, Jörg, WYNS, Lode, MUYLDERMANS, Serge
Published in Antimicrobial Agents and Chemotherapy (01.10.2001)
Published in Antimicrobial Agents and Chemotherapy (01.10.2001)
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High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis
Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A, Saerens, Dirk, Conrath, Katja, Pérez-Morga, David, Skepper, Jeremy N, Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C, De Baetselier, Patrick, Muyldermans, Serge
Published in PLoS pathogens (01.06.2011)
Published in PLoS pathogens (01.06.2011)
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Journal Article
CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy
de Poel, Eyleen, Spelier, Sacha, Korporaal, Ricardo, Lai, Ka Wai, Boj, Sylvia F., Conrath, Katja, van der Ent, Cornelis K., Beekman, Jeffrey M.
Published in Frontiers in molecular biosciences (15.09.2021)
Published in Frontiers in molecular biosciences (15.09.2021)
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