Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model
Tarigopula, Madhusudhan, Davis, 3rd, Robert T, Mungai, Paul T, Ryba, David M, Wieczorek, David F, Cowan, Conrad L, Violin, Jonathan D, Wolska, Beata M, Solaro, R John
Published in Cardiovascular research (15.07.2015)
Published in Cardiovascular research (15.07.2015)
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Journal Article
Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)‑9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain
Chen, Xiao-Tao, Pitis, Philip, Liu, Guodong, Yuan, Catherine, Gotchev, Dimitar, Cowan, Conrad L, Rominger, David H, Koblish, Michael, DeWire, Scott M, Crombie, Aimee L, Violin, Jonathan D, Yamashita, Dennis S
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers
Soergel, David G, Subach, Ruth Ann, Sadler, Brian, Connell, John, Marion, Alan S, Cowan, Conrad L, Violin, Jonathan D, Lark, Michael W
Published in Journal of clinical pharmacology (01.03.2014)
Published in Journal of clinical pharmacology (01.03.2014)
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Journal Article
TRV0109101, a G Protein-Biased Agonist of the µ -Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration
Koblish, Michael, Carr, 3rd, Richard, Siuda, Edward R, Rominger, David H, Gowen-MacDonald, William, Cowan, Conrad L, Crombie, Aimee L, Violin, Jonathan D, Lark, Michael W
Published in The Journal of pharmacology and experimental therapeutics (01.08.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2017)
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Journal Article
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation
Gesty-Palmer, Diane, Chen, Minyong, Reiter, Eric, Ahn, Seungkirl, Nelson, Christopher D., Wang, Shuntai, Eckhardt, Allen E., Cowan, Conrad L., Spurney, Robert F., Luttrell, Louis M., Lefkowitz, Robert J.
Published in The Journal of biological chemistry (21.04.2006)
Published in The Journal of biological chemistry (21.04.2006)
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Journal Article
Biased ligands: pathway validation for novel GPCR therapeutics
Rominger, David H, Cowan, Conrad L, Gowen-MacDonald, William, Violin, Jonathan D
Published in Current opinion in pharmacology (01.06.2014)
Published in Current opinion in pharmacology (01.06.2014)
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Journal Article
TRVO27, A BETA-ARRESTIN BIASED LIGAND AT THE ANGIOTENSIN 2 TYPE 1 RECEPTOR, PRODUCES RAPID, REVERSIBLE CHANGES IN HEMODYNAMICS IN PATIENTS WITH STABLE SYSTOLIC HEART FAILURE
Soergel, David, Subach, Ruth Ann, James, Ian E, Cowan, Conrad L, Gowen, Maxine, Lark, Michael
Published in Journal of the American College of Cardiology (12.03.2013)
Published in Journal of the American College of Cardiology (12.03.2013)
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Journal Article
Lysophosphatidylcholine Inhibits Relaxation of Rabbit Abdominal Aorta Mediated by Endothelium-Derived Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor Independent of Protein Kinase C Activation
Cowan, Conrad L, Steffen, Robert P
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1995)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1995)
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A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine
DeWire, Scott M, Yamashita, Dennis S, Rominger, David H, Liu, Guodong, Cowan, Conrad L, Graczyk, Thomas M, Chen, Xiao-Tao, Pitis, Philip M, Gotchev, Dimitar, Yuan, Catherine, Koblish, Michael, Lark, Michael W, Violin, Jonathan D
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
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Journal Article
Quantitative Cell-Based High-Content Screening for Vasopressin Receptor Agonists Using Transfluor®Technology
Ghosh, Richik N., DeBiasio, Richard, Hudson, Christine C., Ramer, Everett R., Cowan, Conrad L., Oakley, Robert H.
Published in Journal of biomolecular screening (01.08.2005)
Published in Journal of biomolecular screening (01.08.2005)
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Journal Article
Structure Activity Relationships and Discovery of a G Protein Biased mu Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]a2[(9R)-9-(pyridin-2-y1)-6-oxaspiro-[4.5]clecan-9-yl]ethylpamine (TRV130), for the Treatment of Acute Severe Pain
Chen, Xiao-Tao, Pitis, Philip, Liu, Guodong, Yuan, Catherine, Gotchev, Dimitar, Cowan, Conrad L., Rominger, David H., Koblish, Michael, DeWire, Scott M., Crombie, Aimee L., Violin, Jonathan D., Yamashita, Dennis S.
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation
Diane Gesty-Palmer, Minyong Chen, Eric Reiter, Seungkirl Ahn, Christopher D. Nelson, Shuntai Wang, Allen E. Eckhardt, Conrad L. Cowan, Robert F. Spurney, Louis M. Luttrell, Robert J. Lefkowitz
Published in The Journal of biological chemistry (21.04.2006)
Published in The Journal of biological chemistry (21.04.2006)
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Journal Article
Distinct [beta]-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation
Gesty-Palmer, Diane, Chen, Minyong, Reiter, Eric, Ahn, Seungkirl, Nelson, Christopher D, Wang, Shuntai, Eckhardt, Allen E, Cowan, Conrad L, Spurney, Robert F, Luttrell, Louis M, Lefkowitz, Robert J
Published in The Journal of biological chemistry (2006)
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Published in The Journal of biological chemistry (2006)
Journal Article
Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation
Gesty-Palmer, Diane, Chen, Minyong, Reiter, Eric, Ahn, Seungkirl, Nelson, Christopher D, Wang, Shuntai, Eckhardt, Allen E, Cowan, Conrad L, Spurney, Robert F, Luttrell, Louis M, Lefkowitz, Robert J
Published in Journal of Biological Chemistry 16 (281), 10856-10864. (2006) (2006)
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Published in Journal of Biological Chemistry 16 (281), 10856-10864. (2006) (2006)
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