Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis
Rojo-Arreola, Liliana, Long, Thavy, Asarnow, Dan, Suzuki, Brian M, Singh, Rahul, Caffrey, Conor R
Published in PloS one (29.01.2014)
Published in PloS one (29.01.2014)
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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design
Kerr, Iain D., Lee, Ji H., Farady, Christopher J., Marion, Rachael, Rickert, Mathias, Sajid, Mohammed, Pandey, Kailash C., Caffrey, Conor R., Legac, Jennifer, Hansell, Elizabeth, McKerrow, James H., Craik, Charles S., Rosenthal, Philip J., Brinen, Linda S.
Published in The Journal of biological chemistry (18.09.2009)
Published in The Journal of biological chemistry (18.09.2009)
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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
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Published in PLoS neglected tropical diseases (14.07.2009)
Published in PLoS neglected tropical diseases (14.07.2009)
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Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics
Abriola, Laura, Hoyer, Denton, Caffrey, Conor R, Williams, David L, Yoshino, Timothy P, Vermeire, Jon J
Published in PloS one (03.06.2019)
Published in PloS one (03.06.2019)
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Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects
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Published in Molecules (Basel, Switzerland) (23.05.2023)
Published in Molecules (Basel, Switzerland) (23.05.2023)
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Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor
Abdulla, Maha-Hamadien, Lim, Kee-Chong, Sajid, Mohammed, McKerrow, James H, Caffrey, Conor R
Published in PLoS medicine (01.01.2007)
Published in PLoS medicine (01.01.2007)
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A Multienzyme Network Functions in Intestinal Protein Digestion by a Platyhelminth Parasite
Delcroix, Melaine, Sajid, Mohammed, Caffrey, Conor R., Lim, Kee-C., Dvořák, Jan, Hsieh, Ivy, Bahgat, Mahmoud, Dissous, Colette, McKerrow, James H.
Published in The Journal of biological chemistry (22.12.2006)
Published in The Journal of biological chemistry (22.12.2006)
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Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation
Picard, Marion A L, Boissier, Jérôme, Roquis, David, Grunau, Christoph, Allienne, Jean-François, Duval, David, Toulza, Eve, Arancibia, Nathalie, Caffrey, Conor R, Long, Thavy, Nidelet, Sabine, Rohmer, Marine, Cosseau, Céline
Published in PLoS neglected tropical diseases (27.09.2016)
Published in PLoS neglected tropical diseases (27.09.2016)
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Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors
Fajtová, Pavla, Štefanić, Saša, Hradilek, Martin, Dvořák, Jan, Vondrášek, Jiří, Jílková, Adéla, Ulrychová, Lenka, McKerrow, James H, Caffrey, Conor R, Mareš, Michael, Horn, Martin
Published in PLoS neglected tropical diseases (03.06.2015)
Published in PLoS neglected tropical diseases (03.06.2015)
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Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation
Yeh, Yi-Ting, Skinner, Danielle E, Criado-Hidalgo, Ernesto, Chen, Natalie Shee, Garcia-De Herreros, Antoni, El-Sakkary, Nelly, Liu, Lawrence, Zhang, Shun, Kandasamy, Adithan, Chien, Shu, Lasheras, Juan C, Del Álamo, Juan C, Caffrey, Conor R
Published in PLoS pathogens (01.03.2022)
Published in PLoS pathogens (01.03.2022)
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A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response
Soloviova, Kateryna, Fox, Ellen C, Dalton, John P, Caffrey, Conor R, Davies, Stephen J
Published in PLoS neglected tropical diseases (01.01.2019)
Published in PLoS neglected tropical diseases (01.01.2019)
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Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target
Long, Thavy, Rojo-Arreola, Liliana, Shi, Da, El-Sakkary, Nelly, Jarnagin, Kurt, Rock, Fernando, Meewan, Maliwan, Rascón, Jr, Alberto A, Lin, Lin, Cunningham, Katherine A, Lemieux, George A, Podust, Larissa, Abagyan, Ruben, Ashrafi, Kaveh, McKerrow, James H, Caffrey, Conor R
Published in PLoS neglected tropical diseases (01.07.2017)
Published in PLoS neglected tropical diseases (01.07.2017)
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Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity
Ehrenkaufer, Gretchen, Li, Pengyang, Stebbins, Erin E, Kangussu-Marcolino, Monica M, Debnath, Anjan, White, Corin V, Moser, Matthew S, DeRisi, Joseph, Gisselberg, Jolyn, Yeh, Ellen, Wang, Steven C, Company, Ana Hervella, Monti, Ludovica, Caffrey, Conor R, Huston, Christopher D, Wang, Bo, Singh, Upinder
Published in PLoS neglected tropical diseases (01.03.2020)
Published in PLoS neglected tropical diseases (01.03.2020)
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Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch
Jílková, Adéla, Horn, Martin, Řezáčová, Pavlína, Marešová, Lucie, Fajtová, Pavla, Brynda, Jiří, Vondrášek, Jiří, McKerrow, James H., Caffrey, Conor R., Mareš, Michael
Published in Structure (London) (02.12.2014)
Published in Structure (London) (02.12.2014)
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Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
Long, Thavy, Neitz, R Jeffrey, Beasley, Rachel, Kalyanaraman, Chakrapani, Suzuki, Brian M, Jacobson, Matthew P, Dissous, Colette, McKerrow, James H, Drewry, David H, Zuercher, William J, Singh, Rahul, Caffrey, Conor R
Published in PLoS neglected tropical diseases (01.01.2016)
Published in PLoS neglected tropical diseases (01.01.2016)
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Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni
Glaser, Jan, Schurigt, Uta, Suzuki, Brian M, Caffrey, Conor R, Holzgrabe, Ulrike
Published in Molecules (Basel, Switzerland) (12.06.2015)
Published in Molecules (Basel, Switzerland) (12.06.2015)
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A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection
NDAO, Momar, NATH-CHOWDHURY, Milli, KALYANARAMAN, Chakrapani, McKERROW, James H, ARROWOOD, Michael J, CAFFREY, Conor R, SAJID, Mohammed, MARCUS, Victoria, MASHIYAMA, Susan T, SAKANARI, Judy, CHOW, Eric, MACKEY, Zachary, LAND, Kirkwood M, JACOBSON, Matthew P
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022
Caldwell, Nicola, Afshar, Rana, Baragaña, Beatriz, Bustinduy, Amaya L., Caffrey, Conor R., Collins, James J., Fusco, Daniela, Garba, Amadou, Gardner, Mark, Gomes, Mireille, Hoffmann, Karl F., Hsieh, Michael, Lo, Nathan C., McNamara, Case W., Nono, Justin Komguep, Padalino, Gilda, Read, Kevin D., Roestenberg, Meta, Spangenberg, Thomas, Specht, Sabine, Gilbert, Ian H.
Published in ACS infectious diseases (12.05.2023)
Published in ACS infectious diseases (12.05.2023)
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