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Blockade of HLA Antibody-Triggered Classical Complement Activation in Sera from Subjects Dosed with the Anti-C1s Monoclonal Antibody TNT009 - Results from a Randomized First-in-Human Phase 1 Trial
Mühlbacher, Jakob, Jilma, Bernd, Wahrmann, Markus, Bartko, Johann, Eskandary, Farsad, Schörgenhofer, Christian, Schwameis, Michael, Parry, Graham C, Gilbert, James C, Panicker, Sandip, Böhmig, Georg A
Published in Transplantation (01.10.2017)
Published in Transplantation (01.10.2017)
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Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Badri, Prajakta, Jiang, Xuemin, Borodovsky, Anna, Najafian, Nader, Kim, Jae, Clausen, Valerie A., Goel, Varun, Habtemariam, Bahru, Robbie, Gabriel J.
Published in Clinical pharmacokinetics (01.03.2021)
Published in Clinical pharmacokinetics (01.03.2021)
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BCX9930, an Oral Factor D Inhibitor in Development for Treatment of Complement-Mediated Diseases, Inhibits Complement Alternative Pathway (AP) Activity in Healthy Subjects: PO1654
Chen, Xilin, Zhu, Fugang, Parker, Cynthia D., Cornpropst, Melanie, Sheridan, William P., Davidson, Matthew, Babu, Yarlagadda S.
Published in Journal of the American Society of Nephrology (01.10.2021)
Published in Journal of the American Society of Nephrology (01.10.2021)
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The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis
Struglics, André, Okroj, Marcin, Swärd, Per, Frobell, Richard, Saxne, Tore, Lohmander, L. Stefan, Blom, Anna M.
Published in Arthritis research & therapy (06.10.2016)
Published in Arthritis research & therapy (06.10.2016)
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Blockade of HLA Antibody-Triggered Classical Complement Activation in Sera From Subjects Dosed With the Anti-C1s Monoclonal Antibody TNT009-Results from a Randomized First-in-Human Phase 1 Trial
Mühlbacher, Jakob, Jilma, Bernd, Wahrmann, Markus, Bartko, Johann, Eskandary, Farsad, Schörgenhofer, Christian, Schwameis, Michael, Parry, Graham C, Gilbert, James C, Panicker, Sandip, Böhmig, Georg A
Published in Transplantation (01.10.2017)
Published in Transplantation (01.10.2017)
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Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects
Mansur, Fernanda, Teles e Silva, André Luiz, Gomes, Ana Karolyne Santos, Magdalon, Juliana, de Souza, Janaina Sena, Griesi-Oliveira, Karina, Passos-Bueno, Maria Rita, Sertié, Andréa Laurato
Published in International journal of molecular sciences (15.07.2021)
Published in International journal of molecular sciences (15.07.2021)
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Correction to: Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Badri, Prajakta, Jiang, Xuemin, Borodovsky, Anna, Najafan, Nader, Kim, Jae, Clausen, Valerie A., Goel, Varun, Habtemariam, Bahru, Robbie, Gabriel J.
Published in Clinical pharmacokinetics (01.06.2022)
Published in Clinical pharmacokinetics (01.06.2022)
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Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging
Lee, Meelim J., Wang, Chuangqi, Carroll, Molly J., Brubaker, Douglas K., Hyman, Bradley T., Lauffenburger, Douglas A.
Published in Frontiers in neuroscience (30.09.2021)
Published in Frontiers in neuroscience (30.09.2021)
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Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
Ramanjaneya, Manjunath, Butler, Alexandra E., Alkasem, Meis, Bashir, Mohammed, Jerobin, Jayakumar, Godwin, Angela, Moin, Abu Saleh Md, Ahmed, Lina, Elrayess, Mohamed A., Hunt, Steven C., Atkin, Stephen L., Abou-Samra, Abdul-Badi
Published in Frontiers in endocrinology (Lausanne) (30.03.2021)
Published in Frontiers in endocrinology (Lausanne) (30.03.2021)
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of HSK39297 in Chinese Healthy Subjects: A Phase 1 Clinical Trial
Dai, Yuyang, Wu, Feng, Ni, Siyang, Hu, Xiaojun, Han, Ying, Jiao, Ying, Lu, Huan, Liu, Yilin, Wang, Lingling, Lin, Yunfei, Chen, Meixia, Wang, Chao, Wu, Qinghe, Li, Fangqiong, Lu, Laichun
Published in Clinical and translational science (01.07.2025)
Published in Clinical and translational science (01.07.2025)
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Genome-Wide Association Study for Serum Complement C3 and C4 Levels in Healthy Chinese Subjects
Yang, Xiaobo, Sun, Jielin, Gao, Yong, Tan, Aihua, Zhang, Haiying, Hu, Yanling, Feng, Junjie, Qin, Xue, Tao, Sha, Chen, Zhuo, Kim, Seong-Tae, Peng, Tao, Liao, Ming, Lin, Xiaoling, Zhang, Zengfeng, Tang, Minzhong, Li, Li, Mo, Linjian, Liang, Zhengjia, Shi, Deyi, Huang, Zhang, Huang, Xianghua, Liu, Ming, Liu, Qian, Zhang, Shijun, Trent, Jeffrey M., Zheng, S. Lilly, Xu, Jianfeng, Mo, Zengnan
Published in PLoS genetics (01.09.2012)
Published in PLoS genetics (01.09.2012)
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C3 inhibition with pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria treated with eculizumab
Castro, Carlos, Grossi, Federico, Weitz, Ilene Ceil, Maciejewski, Jaroslaw, Sharma, Vivek, Roman, Eloy, Brodsky, Robert A., Tan, Lisa, Di Casoli, Carl, El Mehdi, Delphine, Deschatelets, Pascal, Francois, Cedric
Published in American journal of hematology (01.11.2020)
Published in American journal of hematology (01.11.2020)
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Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer's disease as detected by GC-MS
Nasaruddin, Muhammad Luqman, Hölscher, Christian, Kehoe, Patrick, Graham, Stewart Francis, Green, Brian Desmond
Published in American journal of translational research (01.01.2016)
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Published in American journal of translational research (01.01.2016)
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Trial in Progress: An Open-Label, Phase 2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of KP104 in Complement Inhibitor-Naïve Subjects with Paroxysmal Nocturnal Hemoglobinuria
Zhang, Fengkui, Han, Bing, He, Guangsheng, Zhou, Hu, Wang, Chunrong, Yue, Changhe, Ma, Jay, Rabe, Martin, Fu, Helen, He, Chaomei, Tsui, Ping, Wu, Jingtao, Beddingfield, Frederick, Song, Wenru, Lee, Richard
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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