Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
Ortega Ugalde, Sandra, Boot, Maikel, Commandeur, Jan N. M., Jennings, Paul, Bitter, Wilbert, Vos, J. Chris
Published in Applied microbiology and biotechnology (01.05.2019)
Published in Applied microbiology and biotechnology (01.05.2019)
Get full text
Journal Article
The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by cytochrome P450 BM3 mutants
de Beer, Stephanie B A, van Bergen, Laura A H, Keijzer, Karlijn, Rea, Vanina, Venkataraman, Harini, Guerra, Celia Fonseca, Bickelhaupt, F Matthias, Vermeulen, Nico P E, Commandeur, Jan N M, Geerke, Daan P
Published in Current drug metabolism (01.02.2012)
Published in Current drug metabolism (01.02.2012)
Get more information
Journal Article
Effect of UGT2B72 and CYP2C84 polymorphisms on diclofenac metabolism
Lazarska, Katarzyna E., Dekker, Stefan J., Vermeulen, Nico P.E., Commandeur, Jan N.M.
Published in Toxicology letters (01.03.2018)
Published in Toxicology letters (01.03.2018)
Get full text
Journal Article
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners
Ortega Ugalde, Sandra, de Koning, Coen P., Wallraven, Kerstin, Bruyneel, Ben, Vermeulen, Nico P. E., Grossmann, Tom N., Bitter, Wilbert, Commandeur, Jan N. M., Vos, J. Chris
Published in Applied microbiology and biotechnology (01.11.2018)
Published in Applied microbiology and biotechnology (01.11.2018)
Get full text
Journal Article
A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450‐Catalyzed Substrate Conversion
Luirink, Rosa A., Verkade‐Vreeker, Marlies C. A., Commandeur, Jan N. M., Geerke, Daan P.
Published in Chembiochem : a European journal of chemical biology (15.05.2020)
Published in Chembiochem : a European journal of chemical biology (15.05.2020)
Get full text
Journal Article
Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines
den Braver, Michiel W., den Braver-Sewradj, Shalenie P., Vermeulen, Nico P.E., Commandeur, Jan N.M.
Published in Toxicology letters (24.06.2016)
Published in Toxicology letters (24.06.2016)
Get full text
Journal Article
Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme
Venkataraman, Harini, te Poele, Evelien M, Rosłoniec, Kamila Z, Vermeulen, Nico, Commandeur, Jan N. M, van der Geize, Robert, Dijkhuizen, Lubbert
Published in Applied microbiology and biotechnology (01.06.2015)
Published in Applied microbiology and biotechnology (01.06.2015)
Get full text
Journal Article
A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants
Luirink, Rosa A., Dekker, Stefan J., Capoferri, Luigi, Janssen, Laura F.H., Kuiper, Cynthia L., Ari, Mehmet E., Vermeulen, Nico P.E., Vos, J. Chris, Commandeur, Jan N.M., Geerke, Daan P.
Published in Journal of inorganic biochemistry (01.07.2018)
Published in Journal of inorganic biochemistry (01.07.2018)
Get full text
Journal Article
Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium
Ortega Ugalde, Sandra, Luirink, Rosa A., Geerke, Daan P., Vermeulen, Nico P.E., Bitter, Wilbert, Commandeur, Jan N.M.
Published in Journal of inorganic biochemistry (01.03.2018)
Published in Journal of inorganic biochemistry (01.03.2018)
Get full text
Journal Article
Development of a Novel Cytochrome P450 Bioaffinity Detection System Coupled Online to Gradient Reversed-Phase High-Performance Liquid Chromatography
Kool, Jeroen, van Liempd, Sebastiaan M., Ramautar, Rawi, Schenk, Tim, Meerman, John H.N., Irth, Hubertus, Commandeur, Jan. N.M., Vermeulen, Nico P.E.
Published in Journal of biomolecular screening (01.08.2005)
Published in Journal of biomolecular screening (01.08.2005)
Get full text
Journal Article
Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer
den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Vermeulen, Nico P.E., Commandeur, Jan N.M., Richert, Lysiane, Vos, J. Chris
Published in Toxicology in vitro (01.06.2016)
Published in Toxicology in vitro (01.06.2016)
Get full text
Journal Article
Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals
Vos, J Chris, den Braver-Sewradj, Shalenie P, den Braver, Michiel W, van Dijk, Marc, Zhang, Yongjie, Dekker, Stefan J, Wijaya, Lukas, Vermeulen, Nico P E, Richert, Lysiane, Commandeur, Jan N M
Published in Current drug metabolism (01.01.2018)
Published in Current drug metabolism (01.01.2018)
Get more information
Journal Article
Selective whole-cell biosynthesis of the designer drug metabolites 15- or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants
Reinen, Jelle, Vredenburg, Galvin, Klaering, Karoline, Vermeulen, Nico P.E., Commandeur, Jan N.M., Honing, Maarten, Vos, J. Chris
Published in Journal of molecular catalysis. B, Enzymatic (01.11.2015)
Published in Journal of molecular catalysis. B, Enzymatic (01.11.2015)
Get full text
Journal Article
Biomarkers of free radical damage: Applications in experimental animals and in humans
de Zwart, Loeckie L, Meerman, John H.N, Commandeur, Jan N.M, Vermeulen, Nico P.E
Published in Free Radical Biology and Medicine (1999)
Published in Free Radical Biology and Medicine (1999)
Get full text
Book Review
Journal Article
Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity
Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E, Commandeur, Jan N. M, Honing, Maarten
Published in Analytical and bioanalytical chemistry (01.02.2016)
Published in Analytical and bioanalytical chemistry (01.02.2016)
Get full text
Journal Article
Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants
Vredenburg, Galvin, den Braver-Sewradj, Shalenie, van Vugt-Lussenburg, Barbara M.A., Vermeulen, Nico P.E., Commandeur, Jan N.M., Vos, J. Chris
Published in Toxicology letters (05.01.2015)
Published in Toxicology letters (05.01.2015)
Get full text
Journal Article
Cytochrome P450 bio-affinity detection coupled to gradient HPLC: On-line screening of affinities to cytochrome P4501A2 and 2D6
Kool, Jeroen, van Liempd, Sebastiaan M., Harmsen, Stefan, Beckman, Joran, van Elswijk, Danny, Commandeur, Jan. N.M., Irth, Hubertus, Vermeulen, Nico P.E.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2007)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2007)
Get full text
Journal Article