A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies
Ramaiahgari, Sreenivasa C., den Braver, Michiel W., Herpers, Bram, Terpstra, Valeska, Commandeur, Jan N. M., van de Water, Bob, Price, Leo S.
Published in Archives of toxicology (01.05.2014)
Published in Archives of toxicology (01.05.2014)
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Journal Article
Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
Frydenvang, Karla, Verkade-Vreeker, Marlies C A, Dohmen, Floor, Commandeur, Jan N M, Rafiq, Maria, Mirza, Osman, Jørgensen, Flemming Steen, Geerke, Daan P
Published in PloS one (24.05.2019)
Published in PloS one (24.05.2019)
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Journal Article
Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme
Venkataraman, Harini, te Poele, Evelien M, Rosłoniec, Kamila Z, Vermeulen, Nico, Commandeur, Jan N. M, van der Geize, Robert, Dijkhuizen, Lubbert
Published in Applied microbiology and biotechnology (01.06.2015)
Published in Applied microbiology and biotechnology (01.06.2015)
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Journal Article
Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations
den Braver-Sewradj, Shalenie P, den Braver, Michiel W, Toorneman, Robin M, van Leeuwen, Stephanie, Zhang, Yongjie, Dekker, Stefan J, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris
Published in Chemical research in toxicology (19.02.2018)
Published in Chemical research in toxicology (19.02.2018)
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Journal Article
Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation
Capoferri, Luigi, Verkade-Vreeker, Marlies C A, Buitenhuis, Danny, Commandeur, Jan N M, Pastor, Manuel, Vermeulen, Nico P E, Geerke, Daan P
Published in PloS one (09.11.2015)
Published in PloS one (09.11.2015)
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Journal Article
Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity
Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E, Commandeur, Jan N. M, Honing, Maarten
Published in Analytical and bioanalytical chemistry (01.02.2016)
Published in Analytical and bioanalytical chemistry (01.02.2016)
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Journal Article
Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid
Vredenburg, Galvin, Elias, Naura S, Venkataraman, Harini, Hendriks, Delilah F. G, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris
Published in Chemical research in toxicology (21.04.2014)
Published in Chemical research in toxicology (21.04.2014)
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Journal Article
Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis
Fredriksson, Lisa, Herpers, Bram, Benedetti, Giulia, Matadin, Quraisha, Puigvert, Jordi C., de Bont, Hans, Dragovic, Sanja, Vermeulen, Nico P.E., Commandeur, Jan N.M., Danen, Erik, de Graauw, Marjo, van de Water, Bob
Published in Hepatology (Baltimore, Md.) (01.06.2011)
Published in Hepatology (Baltimore, Md.) (01.06.2011)
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Journal Article
Cytochrome P450-Mediated Bioactivation of Mefenamic Acid to Quinoneimine Intermediates and Inactivation by Human Glutathione S‑Transferases
Venkataraman, Harini, den Braver, Michiel W, Vermeulen, Nico P. E, Commandeur, Jan N. M
Published in Chemical research in toxicology (15.12.2014)
Published in Chemical research in toxicology (15.12.2014)
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Journal Article
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver
Hadi, Mackenzie, Dragovic, Sanja, van Swelm, Rachel, Herpers, Bram, van de Water, Bob, Russel, Frans G. M., Commandeur, Jan N. M., Groothuis, Geny M. M.
Published in Archives of toxicology (01.01.2013)
Published in Archives of toxicology (01.01.2013)
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Journal Article
Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione‑S‑transferase P1‑1
Boerma, Jan Simon, Dragovic, Sanja, Vermeulen, Nico P. E, Commandeur, Jan N. M
Published in Chemical research in toxicology (19.11.2012)
Published in Chemical research in toxicology (19.11.2012)
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Journal Article
Effect of Human Glutathione S‑Transferases on Glutathione-Dependent Inactivation of Cytochrome P450-Dependent Reactive Intermediates of Diclofenac
Dragovic, Sanja, Boerma, Jan Simon, Vermeulen, Nico P. E, Commandeur, Jan N. M
Published in Chemical research in toxicology (18.11.2013)
Published in Chemical research in toxicology (18.11.2013)
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Journal Article
Characterization of Human Cytochrome P450s Involved in the Bioactivation of Tri-ortho-cresyl Phosphate (ToCP)
Reinen, Jelle, Nematollahi, Leyla, Fidder, Alex, Vermeulen, Nico P. E, Noort, Daan, Commandeur, Jan N. M
Published in Chemical research in toxicology (20.04.2015)
Published in Chemical research in toxicology (20.04.2015)
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Journal Article
Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
Ortega Ugalde, Sandra, Boot, Maikel, Commandeur, Jan N. M., Jennings, Paul, Bitter, Wilbert, Vos, J. Chris
Published in Applied microbiology and biotechnology (01.05.2019)
Published in Applied microbiology and biotechnology (01.05.2019)
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Journal Article
Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin
DAMSTEN, Micaela C, COMMANDEUR, Jan N. M, FIDDER, Alex, HULST, Albert G, TOUW, Daan, NOORT, Daan, VERMEULEN, Nico P. E
Published in Drug metabolism and disposition (01.08.2007)
Published in Drug metabolism and disposition (01.08.2007)
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Journal Article
Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR
de Vlieger, Jon S.B., Kolkman, Ard J., Ampt, Kirsten A.M., Commandeur, Jan N.M., Vermeulen, Nico P.E., Kool, Jeroen, Wijmenga, Sybren S., Niessen, Wilfried M.A., Irth, Hubertus, Honing, Maarten
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.03.2010)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.03.2010)
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Journal Article
Trimethoprim: Novel Reactive Intermediates and Bioactivation Pathways by Cytochrome P450s
Damsten, Micaela C, de Vlieger, Jon S. B, Niessen, Wilfried M. A, Irth, Hubertus, Vermeulen, Nico P. E, Commandeur, Jan N. M
Published in Chemical research in toxicology (01.11.2008)
Published in Chemical research in toxicology (01.11.2008)
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Journal Article
Enzyme-Catalyzed Activation of Anticancer Prodrugs
Rooseboom, Martijn, Commandeur, Jan N M, Vermeulen, Nico P E
Published in Pharmacological reviews (01.03.2004)
Published in Pharmacological reviews (01.03.2004)
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Journal Article
Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities
Venhorst, Jennifer, ter Laak, Antonius M, Commandeur, Jan N. M, Funae, Yoshihiko, Hiroi, Toyoko, Vermeulen, Nico P. E
Published in Journal of medicinal chemistry (02.01.2003)
Published in Journal of medicinal chemistry (02.01.2003)
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