Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis
Shailubhai, Kunwar, Palejwala, Vaseem, Arjunan, Krishna Priya, Saykhedkar, Sayali, Nefsky, Bradley, Foss, John A, Comiskey, Stephen, Jacob, Gary S, Plevy, Scott E
Published in World journal of gastrointestinal pharmacology and therapeutics (06.11.2015)
Published in World journal of gastrointestinal pharmacology and therapeutics (06.11.2015)
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Journal Article
Plecanatide, an Oral Guanylate Cyclase C Agonist Acting Locally in the Gastrointestinal Tract, Is Safe and Well-Tolerated in Single Doses
Shailubhai, Kunwar, Comiskey, Stephen, Foss, John A., Feng, Rong, Barrow, Laura, Comer, Gail M., Jacob, Gary S.
Published in Digestive diseases and sciences (01.09.2013)
Published in Digestive diseases and sciences (01.09.2013)
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Journal Article
Su1531 - The Uroguanylin Analog Plecanatide Activates Guanylate Cyclase C Predominantly in the Lumen of the Proximal Small Intestine to Stimulate Chloride and Fluid Secretion and Increase GI Transit in Animal Models
Joshi, Apoorva, Patwa, Viren, Thadi, Anusha, Foss, John A., Comiskey, Stephen, Palejwala, Vaseem A., Shailubhai, Kunwar
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
The Uroguanylin Analog Plecanatide Activates Guanylate Cyclase C Predominantly in the Lumen of the Proximal Small Intestine to Stimulate Chloride and Fluid Secretion and Increase GI Transit in Animal Models
Joshi, Apoorva, Patwa, Viren, Thadi, Anusha, Foss, John A, Comiskey, Stephen, Palejwala, Vaseem A, Shailubhai, Kunwar
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
SP-333, a D-Amino Acid Containing Peptide Agonist of Guanylate Cyclase-C Is a Novel Drug Candidate for Treatment of Gastrointestinal Disorders and Diseases: 1819
Palejwala, Vaseem, Joshi, Apoorva, Patwa, Viren, Comiskey, Stephen, Feng, Rong, Foss, John, Shailubhai, Kunwar
Published in The American journal of gastroenterology (01.10.2014)
Published in The American journal of gastroenterology (01.10.2014)
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Journal Article
SP-333, A Guanylate Cyclase C Agonist, Is A Safe and Well-Tolerated Locally Acting Drug Candidate for Treatment of Gastrointestinal Disorders and Diseases: 1749
Barrow, Laura, Foss, John, Comiskey, Stephen, Feng, Rong, Jacob, Gary, Shailubhai, Kunwar
Published in The American journal of gastroenterology (01.10.2014)
Published in The American journal of gastroenterology (01.10.2014)
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Journal Article
Orally Administered SP-333, a Guanylate Cyclase-C Agonist, Acts Locally in the Lumen of the Distal Intestine to Ameliorate DSS-induced Colitis in Mice: 1533
Foss, John, Feng, Rong, Comiskey, Stephen, Shailubhai, Kunwar
Published in The American journal of gastroenterology (01.10.2012)
Published in The American journal of gastroenterology (01.10.2012)
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Journal Article
Orally Administered Plecanatide, a Guanylate Cyclase-C Agonist, Acts in the Lumen of the Proximal Intestine to Facilitate Normal Bowel Movement in Mice and Monkeys: 1725
Comiskey, Stephen, Foss, John, Jacob, Gary, Shailubhai, Kunwar
Published in The American journal of gastroenterology (01.10.2012)
Published in The American journal of gastroenterology (01.10.2012)
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Journal Article
SP-333, a Proteolysis-resistant Agonist of Guanylate Cyclase-C, Inhibits Activation of NF-κB and Suppresses Production of Inflammatory Cytokines to Ameliorate DSS-induced Colitis in Mice: 1555
Zhang, Graham, Arjunan, Krishna Priya, Foss, John, Comiskey, Stephen, Shailubhai, Kunwar
Published in The American journal of gastroenterology (01.10.2012)
Published in The American journal of gastroenterology (01.10.2012)
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Journal Article
SP-333, A Guanylate Cyclase-C Agonist, Ameliorates DSS-Colitis in Mice Via a Novel Cyclic GMP-Mediated Mechanism: P-198
Shailubhai, Kunwar, Foss, John, Zhang, Graham, Arjunan, Krishna, Feng, Rong, Comiskey, Stephen, Jacob, Gary, Plevy, Scott
Published in Inflammatory bowel diseases (01.12.2012)
Published in Inflammatory bowel diseases (01.12.2012)
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Journal Article
Guanylate Cyclase C Agonists, a New Class of Drug Candidates for Treatment of Inflammatory Bowel Disease: 1208
Shailubhai, Kunwar, Nefsky, Bradely, Masih, Shet, Foss, John, Comiskey, Stephen, Jacob, Gary, Plevy, Scott
Published in The American journal of gastroenterology (01.10.2011)
Published in The American journal of gastroenterology (01.10.2011)
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Journal Article
Plecanatide, a Guanylate Cyclase C Agonist, Improves Bowel Habits and Symptoms Associated with Chronic Constipation in a Phase IIa Clinical Study: 1316
Shailubhai, Kunwar, Barrow, Laura, Talluto, Craig, Comiskey, Stephen, Foss, John, Feng, Rong, Joslyn, Alan, Jacob, Gary
Published in The American journal of gastroenterology (01.10.2011)
Published in The American journal of gastroenterology (01.10.2011)
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Journal Article
Phase II Clinical Evaluation of SP-304, a Guanylate Cyclase-C Agonist, for Treatment of Chronic Constipation: 1322
Shailubhai, Kunwar, Talluto, Craig, Comiskey, Stephen, Foss, John, Joslyn, Alan, Jacob, Gary
Published in The American journal of gastroenterology (01.10.2010)
Published in The American journal of gastroenterology (01.10.2010)
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Journal Article
ULTRA-PURE AGONISTS OF GUANYLATE CYCLASE C, METHOD OF MAKING AND USING SAME
FENG RONG, SHAILUBHAI KUNWAR, ZHAO QIAO, ZHANG GUOQING, BAI JUNCAI, COMISKEY STEPHEN, JIA JUN, ZHOU JUNFENG, ZHANG RUOPING
Year of Publication 11.04.2016
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Year of Publication 11.04.2016
Patent
PROCESS OF PREPARING GUANYLATE CYCLASE C AGONISTS
FENG RONG, SHAILUBHAI KUNWAR, ZHAO QIAO, JIAN JUN, BAI JUNCAI, COMISKEY STEPHEN, ZHOU JUNFENG, ZHANG GUOQUING, ZHANG RUOPING
Year of Publication 05.03.2014
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Year of Publication 05.03.2014
Patent