Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
Gabryszewski, Stanislaw J, Dhingra, Satish K, Combrinck, Jill M, Lewis, Ian A, Callaghan, Paul S, Hassett, Matthew R, Siriwardana, Amila, Henrich, Philipp P, Lee, Andrew H, Gnädig, Nina F, Musset, Lise, Llinás, Manuel, Egan, Timothy J, Roepe, Paul D, Fidock, David A
Published in PLoS pathogens (10.11.2016)
Published in PLoS pathogens (10.11.2016)
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Journal Article
Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites
de Sousa, Ana Carolina C, Maepa, Keletso, Combrinck, Jill M, Egan, Timothy J
Published in Molecules (Basel, Switzerland) (29.03.2020)
Published in Molecules (Basel, Switzerland) (29.03.2020)
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Journal Article
THC shows activity against cultured Plasmodium falciparum
de Sousa, Ana Carolina C., Combrinck, Jill M., Maepa, Keletso, Egan, Timothy J.
Published in Bioorganic & medicinal chemistry letters (15.12.2021)
Published in Bioorganic & medicinal chemistry letters (15.12.2021)
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Journal Article
A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine
Dhingra, Satish K, Redhi, Devasha, Combrinck, Jill M, Yeo, Tomas, Okombo, John, Henrich, Philipp P, Cowell, Annie N, Gupta, Purva, Stegman, Matthew L, Hoke, Jonathan M, Cooper, Roland A, Winzeler, Elizabeth, Mok, Sachel, Egan, Timothy J, Fidock, David A
Published in mBio (09.05.2017)
Published in mBio (09.05.2017)
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Journal Article
Insights into the Role of Heme in the Mechanism of Action of Antimalarials
Combrinck, Jill M, Mabotha, Tebogo E, Ncokazi, Kanyile K, Ambele, Melvin A, Taylor, Dale, Smith, Peter J, Hoppe, Heinrich C, Egan, Timothy J
Published in ACS chemical biology (18.01.2013)
Published in ACS chemical biology (18.01.2013)
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Journal Article
Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites
L'abbate, Fabrizio P., Müller, Ronel, Openshaw, Roxanne, Combrinck, Jill M., de Villiers, Katherine A., Hunter, Roger, Egan, Timothy J.
Published in European journal of medicinal chemistry (05.11.2018)
Published in European journal of medicinal chemistry (05.11.2018)
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Journal Article
Subcellular Localisation of a Quinoline-Containing Fluorescent Cyclometallated Ir III Complex in Plasmodium falciparum
Melis, Diana R, Hsiao, Chiao-Yu, Combrinck, Jill M, Wiesner, Lubbe, Smith, Gregory S
Published in Chembiochem : a European journal of chemical biology (04.05.2021)
Published in Chembiochem : a European journal of chemical biology (04.05.2021)
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Journal Article
The influence of fixation and cryopreservation of cerebrospinal fluid on antigen expression and cell percentages by flow cytometric analysis
Singh, Gabriela, van Laarhoven, Arjan, Adams, Rozanne, Reid, Timothy Dawson, Combrinck, Jill, van Dorp, Suzanne, Riou, Catherine, Thango, Nqobile, Enslin, Johannes, Kruger, Stefan, Figaji, Anthony Aaron, Rohlwink, Ursula Karin
Published in Scientific reports (30.01.2024)
Published in Scientific reports (30.01.2024)
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Journal Article
Subcellular Localisation of a Quinoline‐Containing Fluorescent Cyclometallated IrIII Complex in Plasmodium falciparum
Melis, Diana R., Hsiao, Chiao‐Yu, Combrinck, Jill M., Wiesner, Lubbe, Smith, Gregory S.
Published in Chembiochem : a European journal of chemical biology (04.05.2021)
Published in Chembiochem : a European journal of chemical biology (04.05.2021)
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Journal Article
Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials
Combrinck, Jill M, Fong, Kim Y, Gibhard, Liezl, Smith, Peter J, Wright, David W, Egan, Timothy J
Published in Malaria journal (24.06.2015)
Published in Malaria journal (24.06.2015)
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Journal Article
A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes
Openshaw, Roxanne, Maepa, Keletso, Benjamin, Stefan J, Wainwright, Lauren, Combrinck, Jill M, Hunter, Roger, Egan, Timothy J
Published in ACS infectious diseases (12.02.2021)
Published in ACS infectious diseases (12.02.2021)
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Journal Article
Fate of haem iron in the malaria parasite Plasmodium falciparum
Egan, Timothy J, Combrinck, Jill M, Egan, Joanne, Hearne, Giovanni R, Marques, Helder M, Ntenteni, Skhumbuzo, Sewell, B Trevor, Smith, Peter J, Taylor, Dale, van Schalkwyk, Donelly A, Walden, Jason C
Published in Biochemical journal (15.07.2002)
Published in Biochemical journal (15.07.2002)
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Journal Article
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity
Vanaerschot, Manu, Lucantoni, Leonardo, Li, Tao, Combrinck, Jill M, Ruecker, Andrea, Kumar, T R Santha, Rubiano, Kelly, Ferreira, Pedro E, Siciliano, Giulia, Gulati, Sonia, Henrich, Philipp P, Ng, Caroline L, Murithi, James M, Corey, Victoria C, Duffy, Sandra, Lieberman, Ori J, Veiga, M Isabel, Sinden, Robert E, Alano, Pietro, Delves, Michael J, Lee Sim, Kim, Winzeler, Elizabeth A, Egan, Timothy J, Hoffman, Stephen L, Avery, Vicky M, Fidock, David A
Published in Nature microbiology (01.10.2017)
Published in Nature microbiology (01.10.2017)
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Journal Article
Heteroleptic Rh(III) phenylpyridyl complexes based on an aminoquinoline-benzimidazole hybrid scaffold: Antiplasmodial evaluation and mechanistic insights
Baartzes, Nadia, Combrinck, Jill, Chibale, Kelly, Smith, Gregory S.
Published in Journal of organometallic chemistry (15.09.2022)
Published in Journal of organometallic chemistry (15.09.2022)
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Journal Article
Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents
Van de Walle, Tim, Boone, Maya, Van Puyvelde, Julie, Combrinck, Jill, Smith, Peter J., Chibale, Kelly, Mangelinckx, Sven, D’hooghe, Matthias
Published in European journal of medicinal chemistry (15.07.2020)
Published in European journal of medicinal chemistry (15.07.2020)
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Journal Article
Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes
Baartzes, Nadia, Jordaan, Audrey, Warner, Digby F., Combrinck, Jill, Taylor, Dale, Chibale, Kelly, Smith, Gregory S.
Published in European journal of medicinal chemistry (15.11.2020)
Published in European journal of medicinal chemistry (15.11.2020)
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Journal Article