In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm
Artigas, Laura, Coma, Mireia, Matos-Filipe, Pedro, Aguirre-Plans, Joaquim, Farrés, Judith, Valls, Raquel, Fernandez-Fuentes, Narcis, de la Haba-Rodriguez, Juan, Olvera, Alex, Barbera, Jose, Morales, Rafael, Oliva, Baldo, Mas, Jose Manuel, Srinivasan, Narayanaswamy
Published in PloS one (02.10.2020)
Published in PloS one (02.10.2020)
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Journal Article
Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance
Singh, Itender, Sagare, Abhay P., Coma, Mireia, Perlmutter, David, Gelein, Robert, Bell, Robert D., Deane, Richard J., Zhong, Elaine, Parisi, Margaret, Ciszewski, Joseph, Kasper, R. Tristan, Deane, Rashid
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
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Journal Article
Artificial intelligence assessment of the potential of tocilizumab along with corticosteroids therapy for the management of COVID-19 evoked acute respiratory distress syndrome
Segú-Vergés, Cristina, Artigas, Laura, Coma, Mireia, Peck, Richard W
Published in PloS one (15.02.2023)
Published in PloS one (15.02.2023)
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Journal Article
Application of systems biology to identify pharmacological mechanisms of thrombotic microangiopathy evoked by combined activated prothrombin complex concentrate and emicizumab
Valls, Raquel, Wagg, Jonathan, Paz-Priel, Ido, Man, Gabriel, Artigas, Laura, Jaccard, Georges, Coma, Mireia, Schmitt, Christophe
Published in Scientific reports (21.06.2023)
Published in Scientific reports (21.06.2023)
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Journal Article
The proton-pump inhibitor lansoprazole enhances amyloid beta production
Badiola, Nahuai, Alcalde, Victor, Pujol, Albert, Münter, Lisa-Marie, Multhaup, Gerd, Lleó, Alberto, Coma, Mireia, Soler-López, Montserrat, Aloy, Patrick
Published in PloS one (08.03.2013)
Published in PloS one (08.03.2013)
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Journal Article
Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence
Romeo-Guitart, David, Forés, Joaquim, Herrando-Grabulosa, Mireia, Valls, Raquel, Leiva-Rodríguez, Tatiana, Galea, Elena, González-Pérez, Francisco, Navarro, Xavier, Petegnief, Valerie, Bosch, Assumpció, Coma, Mireia, Mas, José Manuel, Casas, Caty
Published in Scientific reports (30.01.2018)
Published in Scientific reports (30.01.2018)
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Journal Article
Novel Neuroprotective Multicomponent Therapy for Amyotrophic Lateral Sclerosis Designed by Networked Systems
Herrando-Grabulosa, Mireia, Mulet, Roger, Pujol, Albert, Mas, José Manuel, Navarro, Xavier, Aloy, Patrick, Coma, Mireia, Casas, Caty
Published in PloS one (25.01.2016)
Published in PloS one (25.01.2016)
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Journal Article
Elucidating the Mechanism of Action of the Attributed Immunomodulatory Role of Eltrombopag in Primary Immune Thrombocytopenia: An In Silico Approach
Lozano, Maria L., Segú-Vergés, Cristina, Coma, Mireia, Álvarez-Roman, María T., González-Porras, José R., Gutiérrez, Laura, Valcárcel, David, Butta, Nora
Published in International journal of molecular sciences (01.07.2021)
Published in International journal of molecular sciences (01.07.2021)
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Journal Article
In silico evaluation of the role of lisdexamfetamine on attention-deficit/hyperactivity disorder common psychiatric comorbidities: mechanistic insights on binge eating disorder and depression
Gutiérrez-Casares, José Ramón, Segú-Vergés, Cristina, Sabate Chueca, Juncal, Pozo-Rubio, Tamara, Coma, Mireia, Montoto, Carmen, Quintero, Javier
Published in Frontiers in neuroscience (30.06.2023)
Published in Frontiers in neuroscience (30.06.2023)
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Journal Article
In silico clinical trial evaluating lisdexamfetamine's and methylphenidate's mechanism of action computational models in an attention-deficit/hyperactivity disorder virtual patients' population
Gutiérrez-Casares, José Ramón, Quintero, Javier, Segú-Vergés, Cristina, Rodríguez Monterde, Pilar, Pozo-Rubio, Tamara, Coma, Mireia, Montoto, Carmen
Published in Frontiers in psychiatry (02.06.2023)
Published in Frontiers in psychiatry (02.06.2023)
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Journal Article
Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming
Villalba, Adrian, Rodriguez-Fernandez, Silvia, Perna-Barrull, David, Ampudia, Rosa-Maria, Gomez-Muñoz, Laia, Pujol-Autonell, Irma, Aguilera, Eva, Coma, Mireia, Cano-Sarabia, Mary, Vázquez, Federico, Verdaguer, Joan, Vives-Pi, Marta
Published in Frontiers in endocrinology (Lausanne) (13.05.2020)
Published in Frontiers in endocrinology (Lausanne) (13.05.2020)
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Journal Article
Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology
Bertran, Laia, Eigbefoh-Addeh, Ailende, Portillo-Carrasquer, Marta, Barrientos-Riosalido, Andrea, Binetti, Jessica, Aguilar, Carmen, Ugarte Chicote, Javier, Bartra, Helena, Artigas, Laura, Coma, Mireia, Richart, Cristóbal, Auguet, Teresa
Published in Biomedicines (03.06.2022)
Published in Biomedicines (03.06.2022)
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Journal Article
Differential Voltage-dependent K+ Channel Responses during Proliferation and Activation in Macrophages
Vicente, Rubén, Escalada, Artur, Coma, Mireia, Fuster, Gemma, Sánchez-Tilló, Ester, López-Iglesias, Carmen, Soler, Concepció, Solsona, Carles, Celada, Antonio, Felipe, Antonio
Published in The Journal of biological chemistry (21.11.2003)
Published in The Journal of biological chemistry (21.11.2003)
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Journal Article
Clinical, Neuropathologic, and Biochemical Profile of the Amyloid Precursor Protein I716F Mutation
Guardia-Laguarta, Cristina, Pera, Marta, Clarimón, Jordi, Molinuevo, José Luis, Sánchez-Valle, Raquel, Lladó, Albert, Coma, Mireia, Gómez-Isla, Teresa, Blesa, Rafael, Ferrer, Isidre, Lleó, Alberto
Published in Journal of neuropathology and experimental neurology (01.01.2010)
Published in Journal of neuropathology and experimental neurology (01.01.2010)
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Journal Article
Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet
Farrés, Judith, Pujol, Albert, Coma, Mireia, Ruiz, Jose Luis, Naval, Jordi, Mas, José Manuel, Molins, Agustí, Fondevila, Joan, Aloy, Patrick
Published in Nutrition & metabolism (09.12.2010)
Published in Nutrition & metabolism (09.12.2010)
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Journal Article
Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach
Carcereny, Enric, Fernández-Nistal, Alonso, López, Araceli, Montoto, Carmen, Naves, Andrea, Segú-Vergés, Cristina, Coma, Mireia, Jorba, Guillem, Oliva, Baldomero, Mas, Jose Manuel
Published in Oncotarget (16.02.2021)
Published in Oncotarget (16.02.2021)
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Journal Article
The systemic inflammatory response is involved in the regulation of K+ channel expression in brain via TNF‐α‐dependent and ‐independent pathways
Vicente, Rubén, Coma, Mireia, Busquets, Silvia, Moore-Carrasco, Rodrigo, López-Soriano, Francisco J, Argilés, Josep M, Felipe, Antonio
Published in FEBS letters (13.08.2004)
Published in FEBS letters (13.08.2004)
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Journal Article
Clearance of amyloid-β by circulating lipoprotein receptors
Zlokovic, Berislav V, Mayo, Kevin, Perlmutter, David, Zarcone, Troy, Bell, Robert D, Wu, Zhenhua, Deane, Rashid, Goate, Alison, Lenting, Peter J, Zhong, Zhihui, Coma, Mireia, Marky, Andrew, Sagare, Abhay, Johnson, Bradley, Hamm, Katie, Pendu, Ronan
Published in Nature medicine (01.09.2007)
Published in Nature medicine (01.09.2007)
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